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Posterior amygdala regulates sexual and aggressive behaviors in male mice.

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Title: Posterior amygdala regulates sexual and aggressive behaviors in male mice.
Authors: Yamaguchi, Takashi (AUTHOR), Wei, Dongyu (AUTHOR), Song, Soomin C. (AUTHOR), Lim, Byungkook (AUTHOR), Tritsch, Nicolas X. (AUTHOR), Lin, Dayu (AUTHOR)
Source: Nature Neuroscience. Sep2020, Vol. 23 Issue 9, p1111-1124. 14p.
Abstract: Sexual and aggressive behaviors are fundamental to animal survival and reproduction. The medial preoptic nucleus (MPN) and ventrolateral part of the ventromedial hypothalamus (VMHvl) are essential regions for male sexual and aggressive behaviors, respectively. While key inhibitory inputs to the VMHvl and MPN have been identified, the extrahypothalamic excitatory inputs essential for social behaviors remain elusive. Here we identify estrogen receptor alpha (Esr1)-expressing cells in the posterior amygdala (PA) as a main source of excitatory inputs to the hypothalamus and key mediators for mating and fighting in male mice. We find two largely distinct PA subpopulations that differ in connectivity, gene expression, in vivo responses and social behavior relevance. MPN-projecting PAEsr1+ cells are activated during mating and are necessary and sufficient for male sexual behaviors, while VMHvl-projecting PAEsr1+ cells are excited during intermale aggression and promote attacks. These findings place the PA as a key node in both male aggression and reproduction circuits. Yamaguchi et al. identify a little-known amygdalar region, the posterior amygdala, as a key node in male mouse social behaviors. Two largely non-overlapping subpopulations in the posterior amygdala form parallel projections to distinct hypothalamic regions to regulate mating and fighting. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Posterior amygdala regulates sexual and aggressive behaviors in male mice.
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  Data: <searchLink fieldCode="AR" term="%22Yamaguchi%2C+Takashi%22">Yamaguchi, Takashi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Dongyu%22">Wei, Dongyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Soomin+C%2E%22">Song, Soomin C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lim%2C+Byungkook%22">Lim, Byungkook</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tritsch%2C+Nicolas+X%2E%22">Tritsch, Nicolas X.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Dayu%22">Lin, Dayu</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Sep2020, Vol. 23 Issue 9, p1111-1124. 14p.
– Name: Abstract
  Label: Abstract
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  Data: Sexual and aggressive behaviors are fundamental to animal survival and reproduction. The medial preoptic nucleus (MPN) and ventrolateral part of the ventromedial hypothalamus (VMHvl) are essential regions for male sexual and aggressive behaviors, respectively. While key inhibitory inputs to the VMHvl and MPN have been identified, the extrahypothalamic excitatory inputs essential for social behaviors remain elusive. Here we identify estrogen receptor alpha (Esr1)-expressing cells in the posterior amygdala (PA) as a main source of excitatory inputs to the hypothalamus and key mediators for mating and fighting in male mice. We find two largely distinct PA subpopulations that differ in connectivity, gene expression, in vivo responses and social behavior relevance. MPN-projecting PAEsr1+ cells are activated during mating and are necessary and sufficient for male sexual behaviors, while VMHvl-projecting PAEsr1+ cells are excited during intermale aggression and promote attacks. These findings place the PA as a key node in both male aggression and reproduction circuits. Yamaguchi et al. identify a little-known amygdalar region, the posterior amygdala, as a key node in male mouse social behaviors. Two largely non-overlapping subpopulations in the posterior amygdala form parallel projections to distinct hypothalamic regions to regulate mating and fighting. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Sep2020
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