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Association between serum folate levels and schizophrenia based on sex.

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Title: Association between serum folate levels and schizophrenia based on sex.
Authors: Tomioka, Yukiko (AUTHOR), Kinoshita, Makoto (AUTHOR), Umehara, Hidehiro (AUTHOR), Nakayama, Tomohiko (AUTHOR), Watanabe, Shin‐ya (AUTHOR), Nakataki, Masahito (AUTHOR), Numata, Shusuke (AUTHOR), Ohmori, Tetsuro (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Sep2020, Vol. 74 Issue 9, p466-471. 6p. 2 Charts, 3 Graphs.
Subjects: Vitamin B6, Folic acid, Analysis of covariance, Serum, Schizophrenia
Abstract: Aim: Sex differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on sex. With this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by sex. The relations among serum folate levels, plasma total homocysteine (tHcy), and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies. Methods: The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on sex. Spearman's rank correlation was used to evaluate the relations among folate, tHcy, and vitamin B6 levels. Results: In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort. Conclusion: Our findings suggest that: (i) a low serum folate level may be associated with schizophrenia regardless of sex; and (ii) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Association between serum folate levels and schizophrenia based on sex.
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  Data: <searchLink fieldCode="AR" term="%22Tomioka%2C+Yukiko%22">Tomioka, Yukiko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kinoshita%2C+Makoto%22">Kinoshita, Makoto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Umehara%2C+Hidehiro%22">Umehara, Hidehiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nakayama%2C+Tomohiko%22">Nakayama, Tomohiko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Watanabe%2C+Shin‐ya%22">Watanabe, Shin‐ya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nakataki%2C+Masahito%22">Nakataki, Masahito</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Numata%2C+Shusuke%22">Numata, Shusuke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ohmori%2C+Tetsuro%22">Ohmori, Tetsuro</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Sep2020, Vol. 74 Issue 9, p466-471. 6p. 2 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Vitamin+B6%22">Vitamin B6</searchLink><br /><searchLink fieldCode="DE" term="%22Folic+acid%22">Folic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+covariance%22">Analysis of covariance</searchLink><br /><searchLink fieldCode="DE" term="%22Serum%22">Serum</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Aim: Sex differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on sex. With this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by sex. The relations among serum folate levels, plasma total homocysteine (tHcy), and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies. Methods: The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on sex. Spearman's rank correlation was used to evaluate the relations among folate, tHcy, and vitamin B6 levels. Results: In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort. Conclusion: Our findings suggest that: (i) a low serum folate level may be associated with schizophrenia regardless of sex; and (ii) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/pcn.13074
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      – SubjectFull: Analysis of covariance
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      – SubjectFull: Serum
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      – TitleFull: Association between serum folate levels and schizophrenia based on sex.
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              Text: Sep2020
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              Y: 2020
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