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Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly.

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Title: Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly.
Authors: Fanelli, Giuseppe (AUTHOR), Benedetti, Francesco (AUTHOR), Wang, Sheng-Min (AUTHOR), Lee, Soo-Jung (AUTHOR), Jun, Tae-Youn (AUTHOR), Masand, Prakash S. (AUTHOR), Patkar, Ashwin A. (AUTHOR), Han, Changsu (AUTHOR), Serretti, Alessandro (AUTHOR), Pae, Chi-Un (AUTHOR), Fabbri, Chiara (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Oct2020, Vol. 270 Issue 7, p901-910. 10p. 1 Chart, 2 Graphs.
Subjects: Biomarkers, False discovery rate, Geriatric Depression Scale, Blood proteins, Mini-Mental State Examination
Abstract: Depression affects 7% of the elderly population, and it often remains misdiagnosed or untreated. Peripheral biomarkers might aid clinicians by allowing more accurate and well-timed recognition of the disease. We sought to determine if plasma protein levels predict the severity of depressive symptomatology or distinguish patients from healthy individuals. The severity of depressive symptoms and global cognitive functioning were assessed by the Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE) in 152 elderly subjects, 76 of which with major depressive disorder (MDD). Plasma levels of 24 proteins were measured by multiplexing and analyzed as continuous predictors or dichotomized using the median value. The association between individual plasma proteins and MDD risk or depressive symptoms severity was investigated using multiple logistic and linear regressions including relevant covariates. Sensitivity analyses were performed excluding cognitively impaired individuals or non-acute patients with MDD. After adjusting for possible confounders and false discovery rate (FDR) correction, we found lower Fetuin-A levels in MDD patients vs. controls (pFDR = 1.95 × 10–6). This result was confirmed by the sensitivity and dichotomized analyses. Lower prolactin (PRL) levels predicted more severe depressive symptoms in acute MDD patients (pFDR = 0.024). Fetuin-A is a promising biomarker of MDD in the elderly as this protein was negatively associated with the disorder in our sample, regardless of the global cognitive functioning. Lower PRL levels may be a peripheral signature of impaired neuroprotective processes and serotoninergic neurotransmission in more severely depressed patients. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Reduced plasma Fetuin-A is a promising biomarker of depression in the elderly.
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  Data: <searchLink fieldCode="AR" term="%22Fanelli%2C+Giuseppe%22">Fanelli, Giuseppe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benedetti%2C+Francesco%22">Benedetti, Francesco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Sheng-Min%22">Wang, Sheng-Min</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Soo-Jung%22">Lee, Soo-Jung</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jun%2C+Tae-Youn%22">Jun, Tae-Youn</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Masand%2C+Prakash+S%2E%22">Masand, Prakash S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patkar%2C+Ashwin+A%2E%22">Patkar, Ashwin A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Han%2C+Changsu%22">Han, Changsu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serretti%2C+Alessandro%22">Serretti, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pae%2C+Chi-Un%22">Pae, Chi-Un</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fabbri%2C+Chiara%22">Fabbri, Chiara</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2020, Vol. 270 Issue 7, p901-910. 10p. 1 Chart, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22False+discovery+rate%22">False discovery rate</searchLink><br /><searchLink fieldCode="DE" term="%22Geriatric+Depression+Scale%22">Geriatric Depression Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+proteins%22">Blood proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Mini-Mental+State+Examination%22">Mini-Mental State Examination</searchLink>
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  Data: Depression affects 7% of the elderly population, and it often remains misdiagnosed or untreated. Peripheral biomarkers might aid clinicians by allowing more accurate and well-timed recognition of the disease. We sought to determine if plasma protein levels predict the severity of depressive symptomatology or distinguish patients from healthy individuals. The severity of depressive symptoms and global cognitive functioning were assessed by the Geriatric Depression Scale (GDS) and Mini-Mental State Examination (MMSE) in 152 elderly subjects, 76 of which with major depressive disorder (MDD). Plasma levels of 24 proteins were measured by multiplexing and analyzed as continuous predictors or dichotomized using the median value. The association between individual plasma proteins and MDD risk or depressive symptoms severity was investigated using multiple logistic and linear regressions including relevant covariates. Sensitivity analyses were performed excluding cognitively impaired individuals or non-acute patients with MDD. After adjusting for possible confounders and false discovery rate (FDR) correction, we found lower Fetuin-A levels in MDD patients vs. controls (pFDR = 1.95 × 10–6). This result was confirmed by the sensitivity and dichotomized analyses. Lower prolactin (PRL) levels predicted more severe depressive symptoms in acute MDD patients (pFDR = 0.024). Fetuin-A is a promising biomarker of MDD in the elderly as this protein was negatively associated with the disorder in our sample, regardless of the global cognitive functioning. Lower PRL levels may be a peripheral signature of impaired neuroprotective processes and serotoninergic neurotransmission in more severely depressed patients. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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