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Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM).

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Title: Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM).
Authors: Ricardo, Alonso (AUTHOR), Cecilia, Quarracino (AUTHOR), Bárbara, Eizaguirre (AUTHOR), Leila, Cohen (AUTHOR), Berenice, Silva (AUTHOR), Cecilia, Pita (AUTHOR), Ignacio, Rojas Juan (AUTHOR), Pappolla, Agustín (AUTHOR), Miguez, Jimena (AUTHOR), Patrucco, Liliana (AUTHOR), Cristiano, Edgardo (AUTHOR), Carlos, Vrech (AUTHOR), Gabriel, Volman (AUTHOR), Emanuel, Silva (AUTHOR), Andres, Barboza (AUTHOR), Norma, Deri (AUTHOR), Verónica, Tkachuk (AUTHOR), Gisela, Zanga (AUTHOR), Dario, Tavolini (AUTHOR), Laura, Saladino María (AUTHOR)
Source: Neurological Sciences. Nov2020, Vol. 41 Issue 11, p3329-3335. 7p. 1 Diagram, 1 Chart, 1 Graph.
Subjects: Multiple sclerosis, Demographic characteristics, Cohort analysis, Magnetic resonance imaging, Brain damage
Geographic Terms: Argentina, Latin America
Abstract: Background: Primary progressive multiple sclerosis (PPMS) is an infrequent clinical form of multiple sclerosis (MS). Scarce information is available about PPMS in Latin America. The aim of this work is to describe the clinical and demographic characteristics of PPMS patients in Argentina. Material and methods: RelevarEM is a longitudinal, strictly observational registry in Argentina. Clinical and epidemiological data from PPMS patients were described. Results: There were 144 cases of PPMS. They represented 7% of MS patients. The mean age was 44.1 years. The female:male ratio was 1.08. The mean Expanded Disability Status Scale (EDSS) score was 5.5 and the mean disease evolution time was 10.6 years. Oligoclonal bands were found in 72.9%. At the time of diagnosis, magnetic resonance imaging showed spinal cord lesions in 82.6% and contrast-enhancing brain lesions in 18.1% of patients. Almost one third of patients were treated with a disease-modifying drug, and ocrelizumab was the most frequently used (55.8%). Conclusions: PPMS is an infrequent subtype of MS and its recognition is of the highest importance as it has its own evolution, treatment, and prognosis. The importance of our research resides in providing local data and contributing to a better understanding of PPMS and its treatment in Latin America. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM).
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  Data: <searchLink fieldCode="AR" term="%22Ricardo%2C+Alonso%22">Ricardo, Alonso</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cecilia%2C+Quarracino%22">Cecilia, Quarracino</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bárbara%2C+Eizaguirre%22">Bárbara, Eizaguirre</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leila%2C+Cohen%22">Leila, Cohen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berenice%2C+Silva%22">Berenice, Silva</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cecilia%2C+Pita%22">Cecilia, Pita</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ignacio%2C+Rojas+Juan%22">Ignacio, Rojas Juan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pappolla%2C+Agustín%22">Pappolla, Agustín</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miguez%2C+Jimena%22">Miguez, Jimena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patrucco%2C+Liliana%22">Patrucco, Liliana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cristiano%2C+Edgardo%22">Cristiano, Edgardo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carlos%2C+Vrech%22">Carlos, Vrech</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gabriel%2C+Volman%22">Gabriel, Volman</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Emanuel%2C+Silva%22">Emanuel, Silva</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andres%2C+Barboza%22">Andres, Barboza</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Norma%2C+Deri%22">Norma, Deri</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verónica%2C+Tkachuk%22">Verónica, Tkachuk</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gisela%2C+Zanga%22">Gisela, Zanga</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dario%2C+Tavolini%22">Dario, Tavolini</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Laura%2C+Saladino+María%22">Laura, Saladino María</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Nov2020, Vol. 41 Issue 11, p3329-3335. 7p. 1 Diagram, 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Demographic+characteristics%22">Demographic characteristics</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+damage%22">Brain damage</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Argentina%22">Argentina</searchLink><br /><searchLink fieldCode="DE" term="%22Latin+America%22">Latin America</searchLink>
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  Data: Background: Primary progressive multiple sclerosis (PPMS) is an infrequent clinical form of multiple sclerosis (MS). Scarce information is available about PPMS in Latin America. The aim of this work is to describe the clinical and demographic characteristics of PPMS patients in Argentina. Material and methods: RelevarEM is a longitudinal, strictly observational registry in Argentina. Clinical and epidemiological data from PPMS patients were described. Results: There were 144 cases of PPMS. They represented 7% of MS patients. The mean age was 44.1 years. The female:male ratio was 1.08. The mean Expanded Disability Status Scale (EDSS) score was 5.5 and the mean disease evolution time was 10.6 years. Oligoclonal bands were found in 72.9%. At the time of diagnosis, magnetic resonance imaging showed spinal cord lesions in 82.6% and contrast-enhancing brain lesions in 18.1% of patients. Almost one third of patients were treated with a disease-modifying drug, and ocrelizumab was the most frequently used (55.8%). Conclusions: PPMS is an infrequent subtype of MS and its recognition is of the highest importance as it has its own evolution, treatment, and prognosis. The importance of our research resides in providing local data and contributing to a better understanding of PPMS and its treatment in Latin America. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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