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A description of early neurodevelopment in a cohort of HIV-exposed uninfected children.

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Title: A description of early neurodevelopment in a cohort of HIV-exposed uninfected children.
Authors: Strehlau, Renate, van Aswegen, Tamryn, Burke, Megan, Kuhn, Louise, Potterton, Joanne
Source: AIDS Care. Nov2020, Vol. 32 Issue 11, p1421-1428. 8p. 1 Diagram, 4 Charts.
Subjects: Neural development, Breastfeeding, Cognition, Infectious disease transmission, HIV infections, Language & languages, Medical screening, Motor ability, Body mass index, Cross-sectional method, Early diagnosis, Descriptive statistics, Children
Geographic Terms: South Africa
Abstract: Introduction: Successful strategies preventing mother-to-child HIV transmission have resulted in increasing numbers of uninfected children exposed to maternal HIV and ART in-utero, and while breastfeeding. Some reports describe exposure as impacting neurodevelopment. Methods: This cross-sectional analysis included 49 of the 70 HIV-exposed uninfected (HEU) birth-enrolled children as the control arm of an observational cohort study of early treatment in HIV-infected infants in Johannesburg, South Africa. We used the Bayley Scales of Infant and Toddler Development-3rd Edition (BSID-III) to assess neurodevelopment at 12 months of age. Cognitive, language and motor subscale composite scores and performance categories were analysed. We evaluated associations between BSID-III performance categories and cohort variables. Results: Evaluating composite scores according to performance categories showed a higher percentage of scores in the average, high average and superior categories as compared to test reference norms. Maternal BMI ≥ 25 kg/m2 and mid-upper arm circumference ≥ 32 cm were associated with higher than average infant language scores. Six children scored below average (<90) – three in the cognitive and three in the language subscale. Conclusion: No developmental delay was found in ART-exposed HEU children at 12 months of age. A small number of at-risk children suggest ongoing screening, referral and follow-up is needed. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Strehlau%2C+Renate%22&quot;&gt;Strehlau, Renate&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22van+Aswegen%2C+Tamryn%22&quot;&gt;van Aswegen, Tamryn&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Burke%2C+Megan%22&quot;&gt;Burke, Megan&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kuhn%2C+Louise%22&quot;&gt;Kuhn, Louise&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Potterton%2C+Joanne%22&quot;&gt;Potterton, Joanne&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22AIDS+Care%22&quot;&gt;AIDS Care&lt;/searchLink&gt;. Nov2020, Vol. 32 Issue 11, p1421-1428. 8p. 1 Diagram, 4 Charts.
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  Data: Introduction: Successful strategies preventing mother-to-child HIV transmission have resulted in increasing numbers of uninfected children exposed to maternal HIV and ART in-utero, and while breastfeeding. Some reports describe exposure as impacting neurodevelopment. Methods: This cross-sectional analysis included 49 of the 70 HIV-exposed uninfected (HEU) birth-enrolled children as the control arm of an observational cohort study of early treatment in HIV-infected infants in Johannesburg, South Africa. We used the Bayley Scales of Infant and Toddler Development-3rd Edition (BSID-III) to assess neurodevelopment at 12 months of age. Cognitive, language and motor subscale composite scores and performance categories were analysed. We evaluated associations between BSID-III performance categories and cohort variables. Results: Evaluating composite scores according to performance categories showed a higher percentage of scores in the average, high average and superior categories as compared to test reference norms. Maternal BMI ≥ 25 kg/m2 and mid-upper arm circumference ≥ 32 cm were associated with higher than average infant language scores. Six children scored below average (&lt;90) – three in the cognitive and three in the language subscale. Conclusion: No developmental delay was found in ART-exposed HEU children at 12 months of age. A small number of at-risk children suggest ongoing screening, referral and follow-up is needed. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of AIDS Care is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09540121.2020.1736257
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1421
    Subjects:
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Breastfeeding
        Type: general
      – SubjectFull: Cognition
        Type: general
      – SubjectFull: Infectious disease transmission
        Type: general
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Language & languages
        Type: general
      – SubjectFull: Medical screening
        Type: general
      – SubjectFull: Motor ability
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      – SubjectFull: Body mass index
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      – SubjectFull: Cross-sectional method
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      – SubjectFull: Early diagnosis
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Children
        Type: general
      – SubjectFull: South Africa
        Type: general
    Titles:
      – TitleFull: A description of early neurodevelopment in a cohort of HIV-exposed uninfected children.
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            NameFull: Strehlau, Renate
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            NameFull: Burke, Megan
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              M: 11
              Text: Nov2020
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              Y: 2020
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