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Reliability of BOLD signals in chronic stroke‐induced aphasia.

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Title: Reliability of BOLD signals in chronic stroke‐induced aphasia.
Authors: Higgins, James (AUTHOR), Barbieri, Elena (AUTHOR), Wang, Xue (AUTHOR), Mack, Jennifer (AUTHOR), Caplan, David (AUTHOR), Kiran, Swathi (AUTHOR), Rapp, Brenda (AUTHOR), Thompson, Cynthia (AUTHOR), Zinbarg, Richard (AUTHOR), Parrish, Todd (AUTHOR)
Source: European Journal of Neuroscience. Oct2020, Vol. 52 Issue 7, p3963-3978. 16p. 4 Color Photographs, 1 Diagram, 1 Chart, 3 Graphs, 1 Map.
Subjects: Aphasia, Stroke patients, Functional magnetic resonance imaging, Statistical reliability
Abstract: Investigating the neurobiology of language impairment and treatment in chronic stroke aphasia using fMRI requires an understanding of measurement variability within and between participants. In this multicenter study, we evaluated the scan–rescan reliability of an auditory and visual (written) story comprehension paradigm in stroke participants with aphasia (N = 65) and healthy controls (N = 22). The multi‐modal task was conducted twice (~1 week apart) on separate visits upon study enrolment and twice again at completion three months later. A non‐language visuomotor task was studied in the aphasia group only, which was conducted once per time point (3 months apart). While participants were asked to make responses during the comprehension task, these in‐scanner responses were not recorded. Reliability was assessed using intraclass correlation coefficient (ICC) at both group and individual participant levels. The visual story comprehension condition had higher reliability than the auditory condition in both groups, with participants with aphasia exhibiting lower reliability than controls in both conditions (stroke ICC =.43, healthy ICC =.81). Differences in reliability within the group of participants with aphasia were found to be partially explained by overall language impairment as well as greater head motion. In the participants with aphasia, the visuomotor paradigm was found to have greater reliability than the story comprehension task at equivalent interscan intervals (visuomotor = 0.50, comprehension = 0.34), and its reliability was not associated with language impairment. This work highlights the importance of considering the reliability of fMRI tasks in aphasia research, provides strategies to improve reliability and has potential implications for the field of clinical neuroimaging in general. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Reliability of BOLD signals in chronic stroke‐induced aphasia.
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  Data: <searchLink fieldCode="AR" term="%22Higgins%2C+James%22">Higgins, James</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barbieri%2C+Elena%22">Barbieri, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Xue%22">Wang, Xue</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mack%2C+Jennifer%22">Mack, Jennifer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caplan%2C+David%22">Caplan, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kiran%2C+Swathi%22">Kiran, Swathi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rapp%2C+Brenda%22">Rapp, Brenda</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thompson%2C+Cynthia%22">Thompson, Cynthia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zinbarg%2C+Richard%22">Zinbarg, Richard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parrish%2C+Todd%22">Parrish, Todd</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2020, Vol. 52 Issue 7, p3963-3978. 16p. 4 Color Photographs, 1 Diagram, 1 Chart, 3 Graphs, 1 Map.
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  Data: <searchLink fieldCode="DE" term="%22Aphasia%22">Aphasia</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+patients%22">Stroke patients</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+reliability%22">Statistical reliability</searchLink>
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  Data: Investigating the neurobiology of language impairment and treatment in chronic stroke aphasia using fMRI requires an understanding of measurement variability within and between participants. In this multicenter study, we evaluated the scan–rescan reliability of an auditory and visual (written) story comprehension paradigm in stroke participants with aphasia (N = 65) and healthy controls (N = 22). The multi‐modal task was conducted twice (~1 week apart) on separate visits upon study enrolment and twice again at completion three months later. A non‐language visuomotor task was studied in the aphasia group only, which was conducted once per time point (3 months apart). While participants were asked to make responses during the comprehension task, these in‐scanner responses were not recorded. Reliability was assessed using intraclass correlation coefficient (ICC) at both group and individual participant levels. The visual story comprehension condition had higher reliability than the auditory condition in both groups, with participants with aphasia exhibiting lower reliability than controls in both conditions (stroke ICC =.43, healthy ICC =.81). Differences in reliability within the group of participants with aphasia were found to be partially explained by overall language impairment as well as greater head motion. In the participants with aphasia, the visuomotor paradigm was found to have greater reliability than the story comprehension task at equivalent interscan intervals (visuomotor = 0.50, comprehension = 0.34), and its reliability was not associated with language impairment. This work highlights the importance of considering the reliability of fMRI tasks in aphasia research, provides strategies to improve reliability and has potential implications for the field of clinical neuroimaging in general. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Oct2020
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