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Thrombolysis and bridging therapy in patients with acute ischaemic stroke and Covid‐19.

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Title: Thrombolysis and bridging therapy in patients with acute ischaemic stroke and Covid‐19.
Authors: Cappellari, M. (AUTHOR), Zini, A. (AUTHOR), Sangalli, D. (AUTHOR), Cavallini, A. (AUTHOR), Reggiani, M. (AUTHOR), Sepe, F. N. (AUTHOR), Rifino, N. (AUTHOR), Giussani, G. (AUTHOR), Guidetti, D. (AUTHOR), Zedde, M. (AUTHOR), Marcheselli, S. (AUTHOR), Longoni, M. (AUTHOR), Beretta, S. (AUTHOR), Sidoti, V. (AUTHOR), Papurello, D. M. (AUTHOR), Giossi, A. (AUTHOR), Nencini, P. (AUTHOR), Plocco, M. (AUTHOR), Balestrino, M. (AUTHOR), Rota, E. (AUTHOR)
Source: European Journal of Neurology. Dec2020, Vol. 27 Issue 12, p2641-2645. 5p.
Subjects: National Institutes of Health (U.S.), COVID-19, Thrombolytic therapy, Adult respiratory distress syndrome, Acute kidney failure, Cerebral hemorrhage
Geographic Terms: Northern Italy, Italy
Abstract: Background and purpose: Comorbidity of acute ischaemic stroke with Covid‐19 is a challenging condition, potentially influencing the decision of whether to administer intravenous thrombolysis (IVT). We aimed to assess the 1‐month outcome in ischaemic stroke patients with Covid‐19 infection who received IVT alone or before thrombectomy (bridging therapy). Methods: As a collaboration initiative promoted by the Italian Stroke Organization, all Italian stroke units (n = 190) were contacted and invited to participate in data collection on stroke patients with Covid‐19 who received IVT. Results: Seventy‐five invited centers agreed to participate. Thirty patients received IVT alone and 17 received bridging therapy between 21 February 2020 and 30 April 2020 in 20 centers (n = 18, Northern Italy; n = 2, Central Italy). At 1 month, 14 (30.4%) patients died and 20 (62.5%) survivors had a modified Rankin Scale (mRS) score of 3 to 5. At 24 to 36 hours, asymptomatic intracerebral hemorrhage (ICH) was reported in eight (17.4%) patients and symptomatic ICH (sICH) in two (4.3%) patients. Causes of death were severe ischaemic stroke (n = 8), a new ischaemic stroke (n = 2), acute respiratory failure (n = 1), acute renal failure (n = 1), acute myocardial infarction (n = 1), and endocarditis (n = 1). In survivors with a 1‐month mRS score of 3 to 5, baseline glucose level was higher, whereas endovascular procedure time in cases of bridging therapy was longer. Baseline National Institutes of Health Stroke Scale glucose and creatinine levels were higher in patients who died. Conclusions: Intravenous thrombolysis for patients with stroke and Covid‐19 was not a rare event in the most affected areas by pandemic, and rates of 1‐month unfavorable outcomes were high compared to previous data from the pre–Covid‐19 literature. However, risk of sICH was not increased. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Thrombolysis and bridging therapy in patients with acute ischaemic stroke and Covid‐19.
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  Data: <searchLink fieldCode="AR" term="%22Cappellari%2C+M%2E%22">Cappellari, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zini%2C+A%2E%22">Zini, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sangalli%2C+D%2E%22">Sangalli, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavallini%2C+A%2E%22">Cavallini, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reggiani%2C+M%2E%22">Reggiani, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sepe%2C+F%2E+N%2E%22">Sepe, F. N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rifino%2C+N%2E%22">Rifino, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giussani%2C+G%2E%22">Giussani, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guidetti%2C+D%2E%22">Guidetti, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zedde%2C+M%2E%22">Zedde, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marcheselli%2C+S%2E%22">Marcheselli, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Longoni%2C+M%2E%22">Longoni, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Beretta%2C+S%2E%22">Beretta, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sidoti%2C+V%2E%22">Sidoti, V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papurello%2C+D%2E+M%2E%22">Papurello, D. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giossi%2C+A%2E%22">Giossi, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nencini%2C+P%2E%22">Nencini, P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Plocco%2C+M%2E%22">Plocco, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balestrino%2C+M%2E%22">Balestrino, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rota%2C+E%2E%22">Rota, E.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Dec2020, Vol. 27 Issue 12, p2641-2645. 5p.
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  Data: <searchLink fieldCode="DE" term="%22National+Institutes+of+Health+%28U%2ES%2E%29%22">National Institutes of Health (U.S.)</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombolytic+therapy%22">Thrombolytic therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Adult+respiratory+distress+syndrome%22">Adult respiratory distress syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+kidney+failure%22">Acute kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+hemorrhage%22">Cerebral hemorrhage</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Northern+Italy%22">Northern Italy</searchLink><br /><searchLink fieldCode="DE" term="%22Italy%22">Italy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and purpose: Comorbidity of acute ischaemic stroke with Covid‐19 is a challenging condition, potentially influencing the decision of whether to administer intravenous thrombolysis (IVT). We aimed to assess the 1‐month outcome in ischaemic stroke patients with Covid‐19 infection who received IVT alone or before thrombectomy (bridging therapy). Methods: As a collaboration initiative promoted by the Italian Stroke Organization, all Italian stroke units (n = 190) were contacted and invited to participate in data collection on stroke patients with Covid‐19 who received IVT. Results: Seventy‐five invited centers agreed to participate. Thirty patients received IVT alone and 17 received bridging therapy between 21 February 2020 and 30 April 2020 in 20 centers (n = 18, Northern Italy; n = 2, Central Italy). At 1 month, 14 (30.4%) patients died and 20 (62.5%) survivors had a modified Rankin Scale (mRS) score of 3 to 5. At 24 to 36 hours, asymptomatic intracerebral hemorrhage (ICH) was reported in eight (17.4%) patients and symptomatic ICH (sICH) in two (4.3%) patients. Causes of death were severe ischaemic stroke (n = 8), a new ischaemic stroke (n = 2), acute respiratory failure (n = 1), acute renal failure (n = 1), acute myocardial infarction (n = 1), and endocarditis (n = 1). In survivors with a 1‐month mRS score of 3 to 5, baseline glucose level was higher, whereas endovascular procedure time in cases of bridging therapy was longer. Baseline National Institutes of Health Stroke Scale glucose and creatinine levels were higher in patients who died. Conclusions: Intravenous thrombolysis for patients with stroke and Covid‐19 was not a rare event in the most affected areas by pandemic, and rates of 1‐month unfavorable outcomes were high compared to previous data from the pre–Covid‐19 literature. However, risk of sICH was not increased. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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