Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes.
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| Title: | Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes. |
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| Authors: | Brendle, Cornelia (AUTHOR), Klose, Uwe (AUTHOR), Hempel, Johann-Martin (AUTHOR), Schittenhelm, Jens (AUTHOR), Skardelly, Marco (AUTHOR), Tabatabai, Ghazaleh (AUTHOR), Ernemann, Ulrike (AUTHOR), Bender, Benjamin (AUTHOR) |
| Source: | Neurological Sciences. Dec2020, Vol. 41 Issue 12, p3625-3632. 8p. 1 Black and White Photograph, 2 Charts, 2 Graphs. |
| Subjects: | World Health Organization, Oligodendrogliomas, Magnetic susceptibility, Tumor diagnosis, Isocitrate dehydrogenase, Blood volume, Prognosis |
| Abstract: | Purpose: The updated 2016 CNS World Health Organization classification differentiates three main groups of diffuse glioma according to their molecular characteristics: astrocytic tumors with and without isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deleted oligodendrogliomas. The present study aimed to determine whether dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is an independent prognostic marker within the molecular subgroups of diffuse glioma. Methods: Fifty-six patients with treatment-naive gliomas and advanced preoperative MRI examination were assessed retrospectively. The mean and maximal normalized cerebral blood volume values from DSC-MRI within the tumors were measured. Optimal cutoff values for the 1-year progression-free survival (PFS) were defined, and Kaplan-Meier analyses were performed separately for the three glioma subgroups. Results: IDH wild-type astrocytic tumors had a higher mean and maximal perfusion than IDH-mutant astrocytic tumors and oligodendrogliomas. Patients with IDH wild-type astrocytic tumors and a low mean or maximal perfusion had a significantly shorter PFS than patients of the same group with high perfusion (p = 0.0159/0.0112). Furthermore, they had a significantly higher risk for early progression (hazard ratio = 5.6/5.1). This finding was independent of the methylation status of O6-methylguanin-DNA-methyltransferase and variations of the therapy. Within the groups of IDH-mutant astrocytic tumors and oligodendrogliomas, the PFS of low and highly perfused tumors did not differ. Conclusion: High perfusion upon initial diagnosis is not compellingly associated with worse short-term prognosis within the different molecular subgroups of diffuse glioma. Particularly, the overall highly perfused group of IDH wild-type astrocytic tumors contains tumors with low perfusion but unfavorable prognosis. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 146930956 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Brendle%2C+Cornelia%22">Brendle, Cornelia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Klose%2C+Uwe%22">Klose, Uwe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hempel%2C+Johann-Martin%22">Hempel, Johann-Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schittenhelm%2C+Jens%22">Schittenhelm, Jens</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Skardelly%2C+Marco%22">Skardelly, Marco</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tabatabai%2C+Ghazaleh%22">Tabatabai, Ghazaleh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ernemann%2C+Ulrike%22">Ernemann, Ulrike</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bender%2C+Benjamin%22">Bender, Benjamin</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2020, Vol. 41 Issue 12, p3625-3632. 8p. 1 Black and White Photograph, 2 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22World+Health+Organization%22">World Health Organization</searchLink><br /><searchLink fieldCode="DE" term="%22Oligodendrogliomas%22">Oligodendrogliomas</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+susceptibility%22">Magnetic susceptibility</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+diagnosis%22">Tumor diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Isocitrate+dehydrogenase%22">Isocitrate dehydrogenase</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+volume%22">Blood volume</searchLink><br /><searchLink fieldCode="DE" term="%22Prognosis%22">Prognosis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: The updated 2016 CNS World Health Organization classification differentiates three main groups of diffuse glioma according to their molecular characteristics: astrocytic tumors with and without isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deleted oligodendrogliomas. The present study aimed to determine whether dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is an independent prognostic marker within the molecular subgroups of diffuse glioma. Methods: Fifty-six patients with treatment-naive gliomas and advanced preoperative MRI examination were assessed retrospectively. The mean and maximal normalized cerebral blood volume values from DSC-MRI within the tumors were measured. Optimal cutoff values for the 1-year progression-free survival (PFS) were defined, and Kaplan-Meier analyses were performed separately for the three glioma subgroups. Results: IDH wild-type astrocytic tumors had a higher mean and maximal perfusion than IDH-mutant astrocytic tumors and oligodendrogliomas. Patients with IDH wild-type astrocytic tumors and a low mean or maximal perfusion had a significantly shorter PFS than patients of the same group with high perfusion (p = 0.0159/0.0112). Furthermore, they had a significantly higher risk for early progression (hazard ratio = 5.6/5.1). This finding was independent of the methylation status of O6-methylguanin-DNA-methyltransferase and variations of the therapy. Within the groups of IDH-mutant astrocytic tumors and oligodendrogliomas, the PFS of low and highly perfused tumors did not differ. Conclusion: High perfusion upon initial diagnosis is not compellingly associated with worse short-term prognosis within the different molecular subgroups of diffuse glioma. Particularly, the overall highly perfused group of IDH wild-type astrocytic tumors contains tumors with low perfusion but unfavorable prognosis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-020-04474-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 3625 Subjects: – SubjectFull: World Health Organization Type: general – SubjectFull: Oligodendrogliomas Type: general – SubjectFull: Magnetic susceptibility Type: general – SubjectFull: Tumor diagnosis Type: general – SubjectFull: Isocitrate dehydrogenase Type: general – SubjectFull: Blood volume Type: general – SubjectFull: Prognosis Type: general Titles: – TitleFull: Association of dynamic susceptibility magnetic resonance imaging at initial tumor diagnosis with the prognosis of different molecular glioma subtypes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Brendle, Cornelia – PersonEntity: Name: NameFull: Klose, Uwe – PersonEntity: Name: NameFull: Hempel, Johann-Martin – PersonEntity: Name: NameFull: Schittenhelm, Jens – PersonEntity: Name: NameFull: Skardelly, Marco – PersonEntity: Name: NameFull: Tabatabai, Ghazaleh – PersonEntity: Name: NameFull: Ernemann, Ulrike – PersonEntity: Name: NameFull: Bender, Benjamin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2020 Type: published Y: 2020 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 41 – Type: issue Value: 12 Titles: – TitleFull: Neurological Sciences Type: main |
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