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A marine microbiome antifungal targets urgent-threat drug-resistant fungi.

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Title: A marine microbiome antifungal targets urgent-threat drug-resistant fungi.
Authors: Zhang, Fan, Zhao, Miao, Braun, Doug R., Ericksen, Spencer S., Piotrowski, Jeff S., Nelson, Justin, Peng, Jian, Ananiev, Gene E., Chanana, Shaurya, Barns, Kenneth, Fossen, Jen, Sanchez, Hiram, Chevrette, Marc G., Guzei, Ilia A., Zhao, Changgui, Guo, Le, Tang, Weiping, Currie, Cameron R., Rajski, Scott R., Audhya, Anjon
Source: Science (pre-March 2025). 11/20/2020, Vol. 370 Issue 6519, p974-978. 5p. 2 Color Photographs, 1 Graph.
Subjects: Antifungal agents, Mycoses, Microbiota, Metabolomics, Drug traffic
Abstract: New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as C. auris. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A marine microbiome antifungal targets urgent-threat drug-resistant fungi.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Fan%22">Zhang, Fan</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Miao%22">Zhao, Miao</searchLink><br /><searchLink fieldCode="AR" term="%22Braun%2C+Doug+R%2E%22">Braun, Doug R.</searchLink><br /><searchLink fieldCode="AR" term="%22Ericksen%2C+Spencer+S%2E%22">Ericksen, Spencer S.</searchLink><br /><searchLink fieldCode="AR" term="%22Piotrowski%2C+Jeff+S%2E%22">Piotrowski, Jeff S.</searchLink><br /><searchLink fieldCode="AR" term="%22Nelson%2C+Justin%22">Nelson, Justin</searchLink><br /><searchLink fieldCode="AR" term="%22Peng%2C+Jian%22">Peng, Jian</searchLink><br /><searchLink fieldCode="AR" term="%22Ananiev%2C+Gene+E%2E%22">Ananiev, Gene E.</searchLink><br /><searchLink fieldCode="AR" term="%22Chanana%2C+Shaurya%22">Chanana, Shaurya</searchLink><br /><searchLink fieldCode="AR" term="%22Barns%2C+Kenneth%22">Barns, Kenneth</searchLink><br /><searchLink fieldCode="AR" term="%22Fossen%2C+Jen%22">Fossen, Jen</searchLink><br /><searchLink fieldCode="AR" term="%22Sanchez%2C+Hiram%22">Sanchez, Hiram</searchLink><br /><searchLink fieldCode="AR" term="%22Chevrette%2C+Marc+G%2E%22">Chevrette, Marc G.</searchLink><br /><searchLink fieldCode="AR" term="%22Guzei%2C+Ilia+A%2E%22">Guzei, Ilia A.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Changgui%22">Zhao, Changgui</searchLink><br /><searchLink fieldCode="AR" term="%22Guo%2C+Le%22">Guo, Le</searchLink><br /><searchLink fieldCode="AR" term="%22Tang%2C+Weiping%22">Tang, Weiping</searchLink><br /><searchLink fieldCode="AR" term="%22Currie%2C+Cameron+R%2E%22">Currie, Cameron R.</searchLink><br /><searchLink fieldCode="AR" term="%22Rajski%2C+Scott+R%2E%22">Rajski, Scott R.</searchLink><br /><searchLink fieldCode="AR" term="%22Audhya%2C+Anjon%22">Audhya, Anjon</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 11/20/2020, Vol. 370 Issue 6519, p974-978. 5p. 2 Color Photographs, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Antifungal+agents%22">Antifungal agents</searchLink><br /><searchLink fieldCode="DE" term="%22Mycoses%22">Mycoses</searchLink><br /><searchLink fieldCode="DE" term="%22Microbiota%22">Microbiota</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolomics%22">Metabolomics</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+traffic%22">Drug traffic</searchLink>
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  Label: Abstract
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  Data: New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as C. auris. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.abd6919
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