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An assessment of symptom burden in inflammatory bowel diseases to develop a patient preference-weighted symptom score.

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Title: An assessment of symptom burden in inflammatory bowel diseases to develop a patient preference-weighted symptom score.
Authors: van Deen, Welmoed K. (AUTHOR), Obremskey, Alexandra (AUTHOR), Moore, Graham (AUTHOR), van den Akker-van Marle, M. Elske (AUTHOR), Doctor, Jason N. (AUTHOR), Hwang, Caroline (AUTHOR)
Source: Quality of Life Research. 2020, Vol. 29 Issue 12, p3387-3396. 10p. 5 Charts, 2 Graphs.
Subjects: Inflammatory bowel diseases, Symptoms, Abdominal pain, Conjoint analysis, Patient preferences, Overactive bladder
Abstract: Purpose: Inflammatory bowel disease (IBD) patients experience diverse symptoms and the impact of these different symptoms varies substantially. Current disease activity measures do not account for the relative importance of the different symptoms and severity levels. In this study, we aimed to quantify the relative importance of different symptoms for IBD patients and to develop a patient preference-weighted symptom (PWS) score to assess symptom burden in IBD. Methods: We performed a choice-based conjoint analysis (CBCA) survey with 129 IBD patients to estimate the relative importance of four common IBD symptoms: stool frequency, abdominal pain, blood in stools, and urgency. We then developed the PWS score using the preferences obtained from the CBCA, which we validated against existing measures. Results: CBCA revealed that urgency was the most important symptom to patients, followed by abdominal pain and blood in stools. Urgency associated with incontinence received particularly high scores and was perceived to be more than 3 times as important as urgency without incontinence. Our results confirmed that different symptoms are not equally bothersome, and we showed that the relation between symptom-level and importance is not linear. The PWS score, which we developed using these estimates was highly correlated with existing disease activity measures. Conclusions: We quantified the relative importance of four common IBD symptoms and developed the PWS score for IBD, which takes the relative importance of different symptoms and symptom-levels into account. The PWS score can be used to obtain a patient-centered assessment of symptom burden. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: An assessment of symptom burden in inflammatory bowel diseases to develop a patient preference-weighted symptom score.
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  Data: <searchLink fieldCode="AR" term="%22van+Deen%2C+Welmoed+K%2E%22">van Deen, Welmoed K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Obremskey%2C+Alexandra%22">Obremskey, Alexandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moore%2C+Graham%22">Moore, Graham</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+den+Akker-van+Marle%2C+M%2E+Elske%22">van den Akker-van Marle, M. Elske</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Doctor%2C+Jason+N%2E%22">Doctor, Jason N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hwang%2C+Caroline%22">Hwang, Caroline</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. 2020, Vol. 29 Issue 12, p3387-3396. 10p. 5 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Inflammatory+bowel+diseases%22">Inflammatory bowel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Abdominal+pain%22">Abdominal pain</searchLink><br /><searchLink fieldCode="DE" term="%22Conjoint+analysis%22">Conjoint analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+preferences%22">Patient preferences</searchLink><br /><searchLink fieldCode="DE" term="%22Overactive+bladder%22">Overactive bladder</searchLink>
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  Data: Purpose: Inflammatory bowel disease (IBD) patients experience diverse symptoms and the impact of these different symptoms varies substantially. Current disease activity measures do not account for the relative importance of the different symptoms and severity levels. In this study, we aimed to quantify the relative importance of different symptoms for IBD patients and to develop a patient preference-weighted symptom (PWS) score to assess symptom burden in IBD. Methods: We performed a choice-based conjoint analysis (CBCA) survey with 129 IBD patients to estimate the relative importance of four common IBD symptoms: stool frequency, abdominal pain, blood in stools, and urgency. We then developed the PWS score using the preferences obtained from the CBCA, which we validated against existing measures. Results: CBCA revealed that urgency was the most important symptom to patients, followed by abdominal pain and blood in stools. Urgency associated with incontinence received particularly high scores and was perceived to be more than 3 times as important as urgency without incontinence. Our results confirmed that different symptoms are not equally bothersome, and we showed that the relation between symptom-level and importance is not linear. The PWS score, which we developed using these estimates was highly correlated with existing disease activity measures. Conclusions: We quantified the relative importance of four common IBD symptoms and developed the PWS score for IBD, which takes the relative importance of different symptoms and symptom-levels into account. The PWS score can be used to obtain a patient-centered assessment of symptom burden. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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