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A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia.

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Title: A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia.
Authors: Zou, Yuan, Geuverink, Elzemiek, Beukeboom, Leo W., Verhulst, Eveline C., van de Zande, Louis
Source: Science (pre-March 2025). 11/27/2020, Vol. 370 Issue 6520, p1115-1118. 4p. 2 Diagrams, 2 Graphs.
Subjects: Insects, Genomes, Wasp behavior, Embryos, Sex determination, Haplodiploidy
Abstract: Various primary signals direct insect sex determination. In hymenopteran insects, the presence of a paternal genome is needed to initiate female development. When absent, uniparental haploid males develop. We molecularly and functionally identified the instructor sex-determination gene, wasp overruler of masculinization (wom), of the haplodiploid wasp Nasonia vitripennis. This gene contains a P53-like domain coding region and arose by gene duplication and genomic rearrangements. Maternal silencing of wom results in male development of haploid embryos. Upon fertilization, early zygotic transcription from the paternal wom allele is initiated, followed by a timely zygotic expression of transformer (tra), leading to female development. Wom is an instructor gene with a parent-of-origin effect in sex determination. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia.
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  Data: <searchLink fieldCode="AR" term="%22Zou%2C+Yuan%22">Zou, Yuan</searchLink><br /><searchLink fieldCode="AR" term="%22Geuverink%2C+Elzemiek%22">Geuverink, Elzemiek</searchLink><br /><searchLink fieldCode="AR" term="%22Beukeboom%2C+Leo+W%2E%22">Beukeboom, Leo W.</searchLink><br /><searchLink fieldCode="AR" term="%22Verhulst%2C+Eveline+C%2E%22">Verhulst, Eveline C.</searchLink><br /><searchLink fieldCode="AR" term="%22van+de+Zande%2C+Louis%22">van de Zande, Louis</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 11/27/2020, Vol. 370 Issue 6520, p1115-1118. 4p. 2 Diagrams, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Insects%22">Insects</searchLink><br /><searchLink fieldCode="DE" term="%22Genomes%22">Genomes</searchLink><br /><searchLink fieldCode="DE" term="%22Wasp+behavior%22">Wasp behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Embryos%22">Embryos</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+determination%22">Sex determination</searchLink><br /><searchLink fieldCode="DE" term="%22Haplodiploidy%22">Haplodiploidy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Various primary signals direct insect sex determination. In hymenopteran insects, the presence of a paternal genome is needed to initiate female development. When absent, uniparental haploid males develop. We molecularly and functionally identified the instructor sex-determination gene, wasp overruler of masculinization (wom), of the haplodiploid wasp Nasonia vitripennis. This gene contains a P53-like domain coding region and arose by gene duplication and genomic rearrangements. Maternal silencing of wom results in male development of haploid embryos. Upon fertilization, early zygotic transcription from the paternal wom allele is initiated, followed by a timely zygotic expression of transformer (tra), leading to female development. Wom is an instructor gene with a parent-of-origin effect in sex determination. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=147304271
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    Identifiers:
      – Type: doi
        Value: 10.1126/science.abb8949
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      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 1115
    Subjects:
      – SubjectFull: Insects
        Type: general
      – SubjectFull: Genomes
        Type: general
      – SubjectFull: Wasp behavior
        Type: general
      – SubjectFull: Embryos
        Type: general
      – SubjectFull: Sex determination
        Type: general
      – SubjectFull: Haplodiploidy
        Type: general
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      – TitleFull: A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia.
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            NameFull: Beukeboom, Leo W.
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            NameFull: Verhulst, Eveline C.
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            NameFull: van de Zande, Louis
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            – D: 27
              M: 11
              Text: 11/27/2020
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              Y: 2020
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