Rapid and accurate diagnosis of brain abscess caused by Nocardia asiatica with a combination of Ziehl‐Neelsen staining and metagenomics next‐generation sequencing.
Saved in:
| Title: | Rapid and accurate diagnosis of brain abscess caused by Nocardia asiatica with a combination of Ziehl‐Neelsen staining and metagenomics next‐generation sequencing. |
|---|---|
| Authors: | Huang, T. (AUTHOR), Chen, Y. (AUTHOR), Zhang, J. (AUTHOR), He, R. (AUTHOR), Qu, D. (AUTHOR), Ye, Q. (AUTHOR), Chen, X. (AUTHOR) |
| Source: | European Journal of Neurology. Jan2021, Vol. 28 Issue 1, p355-357. 3p. |
| Subjects: | Brain abscess, Nucleotide sequencing, Nocardia, Metagenomics, Communicable diseases, Breast cancer |
| Abstract: | Background and purpose: Early and accurate diagnosis is vital in cerebral nocardiosis, a very rare and infectious disease associated with a high mortality rate. Herein, we report a case that a patient with brain abscess was swiftly diagnosed and successfully treated. Methods: We report a case of a 61‐year‐old woman with a brain abscess caused by Nocardia asiatica, diagnosed by a combination of Ziehl‐Neelsen staining and metagenomics next‐generation sequencing (mNGS). Results: A 61‐year‐old woman with left breast cancer resection, diabetes mellitus and a 7‐month discontinuous cough and fever was admitted to our hospital. On the third day of hospitalization, she experienced a sudden loss of consciousness and was diagnosed with a brain abscess and a pathological change in cerebral mass on brain magnetic resonance imaging (MRI). Due to the failure of culturing any microorganisms from the pup, the dissected sample from the patient with Ziehl‐Neelsen staining tested positive for acid‐fast bacilli and was subjected to mNGS. The pathogen was identified as N. asiatica and the patient was treated accordingly with linezolid and trimethoprim‐sulfamethoxazole until complete recovery was confirmed by the follow‐up cerebral MRI. Conclusions: This is the first case report of a brain abscess caused by N. asiatica being swiftly diagnosed by a combination of Ziehl‐Neelsen staining and mNGS. This rapid diagnosis allowed us to successfully treat this rare infection. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 147773148 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Rapid and accurate diagnosis of brain abscess caused by Nocardia asiatica with a combination of Ziehl‐Neelsen staining and metagenomics next‐generation sequencing. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Huang%2C+T%2E%22">Huang, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Y%2E%22">Chen, Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+J%2E%22">Zhang, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22He%2C+R%2E%22">He, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qu%2C+D%2E%22">Qu, D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ye%2C+Q%2E%22">Ye, Q.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+X%2E%22">Chen, X.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jan2021, Vol. 28 Issue 1, p355-357. 3p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Brain+abscess%22">Brain abscess</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleotide+sequencing%22">Nucleotide sequencing</searchLink><br /><searchLink fieldCode="DE" term="%22Nocardia%22">Nocardia</searchLink><br /><searchLink fieldCode="DE" term="%22Metagenomics%22">Metagenomics</searchLink><br /><searchLink fieldCode="DE" term="%22Communicable+diseases%22">Communicable diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer%22">Breast cancer</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose: Early and accurate diagnosis is vital in cerebral nocardiosis, a very rare and infectious disease associated with a high mortality rate. Herein, we report a case that a patient with brain abscess was swiftly diagnosed and successfully treated. Methods: We report a case of a 61‐year‐old woman with a brain abscess caused by Nocardia asiatica, diagnosed by a combination of Ziehl‐Neelsen staining and metagenomics next‐generation sequencing (mNGS). Results: A 61‐year‐old woman with left breast cancer resection, diabetes mellitus and a 7‐month discontinuous cough and fever was admitted to our hospital. On the third day of hospitalization, she experienced a sudden loss of consciousness and was diagnosed with a brain abscess and a pathological change in cerebral mass on brain magnetic resonance imaging (MRI). Due to the failure of culturing any microorganisms from the pup, the dissected sample from the patient with Ziehl‐Neelsen staining tested positive for acid‐fast bacilli and was subjected to mNGS. The pathogen was identified as N. asiatica and the patient was treated accordingly with linezolid and trimethoprim‐sulfamethoxazole until complete recovery was confirmed by the follow‐up cerebral MRI. Conclusions: This is the first case report of a brain abscess caused by N. asiatica being swiftly diagnosed by a combination of Ziehl‐Neelsen staining and mNGS. This rapid diagnosis allowed us to successfully treat this rare infection. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=147773148 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.14533 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 355 Subjects: – SubjectFull: Brain abscess Type: general – SubjectFull: Nucleotide sequencing Type: general – SubjectFull: Nocardia Type: general – SubjectFull: Metagenomics Type: general – SubjectFull: Communicable diseases Type: general – SubjectFull: Breast cancer Type: general Titles: – TitleFull: Rapid and accurate diagnosis of brain abscess caused by Nocardia asiatica with a combination of Ziehl‐Neelsen staining and metagenomics next‐generation sequencing. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Huang, T. – PersonEntity: Name: NameFull: Chen, Y. – PersonEntity: Name: NameFull: Zhang, J. – PersonEntity: Name: NameFull: He, R. – PersonEntity: Name: NameFull: Qu, D. – PersonEntity: Name: NameFull: Ye, Q. – PersonEntity: Name: NameFull: Chen, X. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 28 – Type: issue Value: 1 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
