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Fractional Exhaled Nitric Oxide(FENO), Lung Function and Airway Hyperresponsiveness in Naïve Atopic Asthmatic Children.

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Title: Fractional Exhaled Nitric Oxide(FENO), Lung Function and Airway Hyperresponsiveness in Naïve Atopic Asthmatic Children.
Authors: del Giudice, Michele Miraglia (AUTHOR), Brunese, F. P. (AUTHOR), Piacentini, G. L. (AUTHOR), Pedullà, M. (AUTHOR), Capristo, C. (AUTHOR), Decimo, F. (AUTHOR), Capristo, A. F. (AUTHOR)
Source: Journal of Asthma. Oct2004, Vol. 41 Issue 7, p753-765. 7p.
Subjects: Nitric oxide, Asthma in children, Asthmatics, Pediatric respiratory diseases, Bronchial spasm, Asthma
Abstract: Background. Measurement of fractional exhaled nitric oxide(FENO) is a noninvasive, simple, well-tolerated, and reproducible marker of airway inflammation. Asthmatic children with normal respiratory function could be affected by airway inflammation. The aim of this study was to assess the correlation between FENO and bronchial hyperesponsiveness(BHR) to methacholine, and between FENO and lung function in atopic children with intermittent asthma. METHODS: Thirty-seven children(21 male), aged 7.2–14.4 years(median: 10.9 years), suffering from mild intermittent atopic asthma with a physician-diagnosed history of wheezing and/or chest tightness were studied. None had taken anti-asthmatic therapy for at least three months before the study. No child had symptoms of respiratory tract infection in the month before the study. All subjects underwent FENO measurement, pulmonary function testing and the methacholine provocation tests. RESULTS: The mean percentages of FEV1 and FEF25–27 were 91.9 ± 10.5 and 88.3 ± 11.8, respectively. The mean FENO was 62.2 ± 39.2 ppb and PC20 methacholine was 0.93 mg/ml ± 0.54. Significant correlations were identified between FENO and FEV1(p < 0.0059, r = 0.468) and between FENO and FEF25–75(p < 0.0098, r = 0.439). There was no correlation between FENO and logPC20(p = 0.14). CONCLUSIONS: A single FENO measurement is probably of scarce prognostic and predictive value and it is not surprising to find discordance with BHR. We suggest that FENO measurement could represent a good marker of airway inflammation also in naïve atopic children with intermittent asthma. Repeated measurements over time are probably necessary to understand better the clinical implications of the data obtained in this study. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Fractional Exhaled Nitric Oxide(FENO), Lung Function and Airway Hyperresponsiveness in Na&#239;ve Atopic Asthmatic Children.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22del+Giudice%2C+Michele+Miraglia%22&quot;&gt;del Giudice, Michele Miraglia&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brunese%2C+F%2E+P%2E%22&quot;&gt;Brunese, F. P.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Piacentini%2C+G%2E+L%2E%22&quot;&gt;Piacentini, G. L.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pedull&#224;%2C+M%2E%22&quot;&gt;Pedull&#224;, M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Capristo%2C+C%2E%22&quot;&gt;Capristo, C.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Decimo%2C+F%2E%22&quot;&gt;Decimo, F.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Capristo%2C+A%2E+F%2E%22&quot;&gt;Capristo, A. F.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Asthma%22&quot;&gt;Journal of Asthma&lt;/searchLink&gt;. Oct2004, Vol. 41 Issue 7, p753-765. 7p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nitric+oxide%22&quot;&gt;Nitric oxide&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Asthma+in+children%22&quot;&gt;Asthma in children&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Asthmatics%22&quot;&gt;Asthmatics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pediatric+respiratory+diseases%22&quot;&gt;Pediatric respiratory diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bronchial+spasm%22&quot;&gt;Bronchial spasm&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Asthma%22&quot;&gt;Asthma&lt;/searchLink&gt;
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  Label: Abstract
  Group: Ab
  Data: Background. Measurement of fractional exhaled nitric oxide(FENO) is a noninvasive, simple, well-tolerated, and reproducible marker of airway inflammation. Asthmatic children with normal respiratory function could be affected by airway inflammation. The aim of this study was to assess the correlation between FENO and bronchial hyperesponsiveness(BHR) to methacholine, and between FENO and lung function in atopic children with intermittent asthma. METHODS: Thirty-seven children(21 male), aged 7.2–14.4 years(median: 10.9 years), suffering from mild intermittent atopic asthma with a physician-diagnosed history of wheezing and/or chest tightness were studied. None had taken anti-asthmatic therapy for at least three months before the study. No child had symptoms of respiratory tract infection in the month before the study. All subjects underwent FENO measurement, pulmonary function testing and the methacholine provocation tests. RESULTS: The mean percentages of FEV1 and FEF25–27 were 91.9 &#177; 10.5 and 88.3 &#177; 11.8, respectively. The mean FENO was 62.2 &#177; 39.2 ppb and PC20 methacholine was 0.93 mg/ml &#177; 0.54. Significant correlations were identified between FENO and FEV1(p &lt; 0.0059, r = 0.468) and between FENO and FEF25–75(p &lt; 0.0098, r = 0.439). There was no correlation between FENO and logPC20(p = 0.14). CONCLUSIONS: A single FENO measurement is probably of scarce prognostic and predictive value and it is not surprising to find discordance with BHR. We suggest that FENO measurement could represent a good marker of airway inflammation also in na&#239;ve atopic children with intermittent asthma. Repeated measurements over time are probably necessary to understand better the clinical implications of the data obtained in this study. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of Asthma is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1081/JAS-200027862
    Languages:
      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 753
    Subjects:
      – SubjectFull: Nitric oxide
        Type: general
      – SubjectFull: Asthma in children
        Type: general
      – SubjectFull: Asthmatics
        Type: general
      – SubjectFull: Pediatric respiratory diseases
        Type: general
      – SubjectFull: Bronchial spasm
        Type: general
      – SubjectFull: Asthma
        Type: general
    Titles:
      – TitleFull: Fractional Exhaled Nitric Oxide(FENO), Lung Function and Airway Hyperresponsiveness in Naïve Atopic Asthmatic Children.
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            NameFull: del Giudice, Michele Miraglia
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            NameFull: Brunese, F. P.
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            NameFull: Piacentini, G. L.
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            NameFull: Pedullà, M.
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            NameFull: Capristo, C.
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            NameFull: Decimo, F.
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            NameFull: Capristo, A. F.
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              Text: Oct2004
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              Y: 2004
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            – TitleFull: Journal of Asthma
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