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Loneliness and depression dissociated on parietal-centered networks in cognitive and resting states.

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Title: Loneliness and depression dissociated on parietal-centered networks in cognitive and resting states.
Authors: Shao, Robin, Liu, Ho-Ling, Huang, Chih-Mao, Chen, Yao-Liang, Gao, Mengxia, Lee, Shwu-Hua, Lin, Chemin, Lee, Tatia M. C.
Source: Psychological Medicine. Dec2020, Vol. 50 Issue 6, p2691-2701. 11p.
Subjects: Cognition, Mental depression, Limbic system, Loneliness, Neuropsychological tests, Reaction time
Abstract: Background: Perceived loneliness, an increasingly prevalent social issue, is closely associated with major depressive disorder (MDD). However, the neural mechanisms previously implicated in key cognitive and affective processes in loneliness and MDD still remain unclear. Such understanding is critical for delineating the psychobiological basis of the relationship between loneliness and MDD. Methods: We isolated the unique and interactive cognitive and neural substrates of loneliness and MDD among 27 MDD patients (mean age = 51.85 years, 20 females), and 25 matched healthy controls (HCs; mean age = 48.72 years, 19 females). We assessed participants' behavioral performance and neural regional and network functions on a Stroop color-word task, and their resting-state neural connectivity. Results: Behaviorally, we found greater incongruence-related accuracy cost in MDD patients, but reduced incongruence effect on reaction time in lonelier individuals. When performing the Stroop task, loneliness positively predicted prefrontal-anterior cingulate-parietal connectivity across all participants, whereas MDD patients showed a decrease in connectivity compared to controls. Furthermore, loneliness negatively predicted parietal and cerebellar activities in MDD patients, but positively predicted the same activities in HCs. During resting state, MDD patients showed reduced parietal-anterior cingulate connectivity, which again positively correlated with loneliness in this group. Conclusions: We speculate the distinct neurocognitive profile of loneliness might indicate increase in both bottom-up attention and top-down executive control functions. However, the upregulated cognitive control processes in lonely individuals may eventually become exhausted, which may in turn predispose to MDD onset. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 148113226
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PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Loneliness and depression dissociated on parietal-centered networks in cognitive and resting states.
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  Data: <searchLink fieldCode="AR" term="%22Shao%2C+Robin%22">Shao, Robin</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Ho-Ling%22">Liu, Ho-Ling</searchLink><br /><searchLink fieldCode="AR" term="%22Huang%2C+Chih-Mao%22">Huang, Chih-Mao</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Yao-Liang%22">Chen, Yao-Liang</searchLink><br /><searchLink fieldCode="AR" term="%22Gao%2C+Mengxia%22">Gao, Mengxia</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Shwu-Hua%22">Lee, Shwu-Hua</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Chemin%22">Lin, Chemin</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Tatia+M%2E+C%2E%22">Lee, Tatia M. C.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Dec2020, Vol. 50 Issue 6, p2691-2701. 11p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Limbic+system%22">Limbic system</searchLink><br /><searchLink fieldCode="DE" term="%22Loneliness%22">Loneliness</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Reaction+time%22">Reaction time</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Perceived loneliness, an increasingly prevalent social issue, is closely associated with major depressive disorder (MDD). However, the neural mechanisms previously implicated in key cognitive and affective processes in loneliness and MDD still remain unclear. Such understanding is critical for delineating the psychobiological basis of the relationship between loneliness and MDD. Methods: We isolated the unique and interactive cognitive and neural substrates of loneliness and MDD among 27 MDD patients (mean age = 51.85 years, 20 females), and 25 matched healthy controls (HCs; mean age = 48.72 years, 19 females). We assessed participants' behavioral performance and neural regional and network functions on a Stroop color-word task, and their resting-state neural connectivity. Results: Behaviorally, we found greater incongruence-related accuracy cost in MDD patients, but reduced incongruence effect on reaction time in lonelier individuals. When performing the Stroop task, loneliness positively predicted prefrontal-anterior cingulate-parietal connectivity across all participants, whereas MDD patients showed a decrease in connectivity compared to controls. Furthermore, loneliness negatively predicted parietal and cerebellar activities in MDD patients, but positively predicted the same activities in HCs. During resting state, MDD patients showed reduced parietal-anterior cingulate connectivity, which again positively correlated with loneliness in this group. Conclusions: We speculate the distinct neurocognitive profile of loneliness might indicate increase in both bottom-up attention and top-down executive control functions. However, the upregulated cognitive control processes in lonely individuals may eventually become exhausted, which may in turn predispose to MDD onset. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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              Text: Dec2020
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