Functional connectivity and topology in patients with restless legs syndrome: a case–control resting‐state functional magnetic resonance imaging study.
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| Title: | Functional connectivity and topology in patients with restless legs syndrome: a case–control resting‐state functional magnetic resonance imaging study. |
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| Authors: | Tuovinen, N. (AUTHOR), Stefani, A. (AUTHOR), Mitterling, T. (AUTHOR), Heidbreder, A. (AUTHOR), Frauscher, B. (AUTHOR), Gizewski, E. R. (AUTHOR), Poewe, W. (AUTHOR), Högl, B. (AUTHOR), Scherfler, C. (AUTHOR) |
| Source: | European Journal of Neurology. Feb2021, Vol. 28 Issue 2, p448-458. 11p. |
| Subjects: | Functional magnetic resonance imaging, Restless legs syndrome, Functional connectivity, Independent component analysis, Diagnostic imaging |
| Abstract: | Background and purpose: Functional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients. Methods: Eighty‐two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha‐2‐delta ligands as mono‐ or polytherapy combined with dopaminergic medication, n = 10), and 82 individually age‐ and gender‐matched healthy controls were studied with resting‐state functional magnetic resonance imaging. Connectivity of 12 resting‐state networks was investigated with independent component analysis, and network topology was studied with graph methods among 410 brain regions. Results: Patients with restless legs syndrome showed significantly higher connectivity within salience (p = 0.029), executive (p = 0.001), and cerebellar (p = 0.041) networks, as well as significantly lower (p < 0.05) cerebello‐frontal communication compared to controls. In addition, they had a significantly higher (p < 0.05) clustering coefficient and local efficiency in motor and frontal regions; lower clustering coefficient in the central sulcus; and lower local efficiency in the central opercular cortex, temporal, parieto‐occipital, cuneus, and occipital regions compared to controls. Untreated patients had significantly lower (p < 0.05) cerebello‐parietal communication compared to healthy controls. Connectivity between the thalamus and frontal regions was significantly increased (p < 0.05) in patients on dopaminergic medication compared to untreated patients and controls. Conclusions: Networks with higher intranetwork connectivity (i.e., salience, executive, cerebellar) and lower cerebello‐frontal connectivity in the restless legs syndrome patients, as well as lower cerebello‐parietal connectivity in untreated patients, correspond to regions associated with attention, response inhibitory control, and processing of sensory information. Intact cerebello‐parietal communication and increased thalamic connectivity to the prefrontal regions in patients on dopaminergic medication suggests a treatment effect on thalamus. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 148145017 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Functional connectivity and topology in patients with restless legs syndrome: a case–control resting‐state functional magnetic resonance imaging study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Tuovinen%2C+N%2E%22">Tuovinen, N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stefani%2C+A%2E%22">Stefani, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mitterling%2C+T%2E%22">Mitterling, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heidbreder%2C+A%2E%22">Heidbreder, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frauscher%2C+B%2E%22">Frauscher, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gizewski%2C+E%2E+R%2E%22">Gizewski, E. R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poewe%2C+W%2E%22">Poewe, W.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Högl%2C+B%2E%22">Högl, B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scherfler%2C+C%2E%22">Scherfler, C.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Feb2021, Vol. 28 Issue 2, p448-458. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Restless+legs+syndrome%22">Restless legs syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Independent+component+analysis%22">Independent component analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose: Functional connectivity studies revealed alterations within thalamic, salience, and default mode networks in restless legs syndrome patients. Methods: Eighty‐two patients with restless legs syndrome (untreated, n = 30; on dopaminergic medication, n = 42; on alpha‐2‐delta ligands as mono‐ or polytherapy combined with dopaminergic medication, n = 10), and 82 individually age‐ and gender‐matched healthy controls were studied with resting‐state functional magnetic resonance imaging. Connectivity of 12 resting‐state networks was investigated with independent component analysis, and network topology was studied with graph methods among 410 brain regions. Results: Patients with restless legs syndrome showed significantly higher connectivity within salience (p = 0.029), executive (p = 0.001), and cerebellar (p = 0.041) networks, as well as significantly lower (p < 0.05) cerebello‐frontal communication compared to controls. In addition, they had a significantly higher (p < 0.05) clustering coefficient and local efficiency in motor and frontal regions; lower clustering coefficient in the central sulcus; and lower local efficiency in the central opercular cortex, temporal, parieto‐occipital, cuneus, and occipital regions compared to controls. Untreated patients had significantly lower (p < 0.05) cerebello‐parietal communication compared to healthy controls. Connectivity between the thalamus and frontal regions was significantly increased (p < 0.05) in patients on dopaminergic medication compared to untreated patients and controls. Conclusions: Networks with higher intranetwork connectivity (i.e., salience, executive, cerebellar) and lower cerebello‐frontal connectivity in the restless legs syndrome patients, as well as lower cerebello‐parietal connectivity in untreated patients, correspond to regions associated with attention, response inhibitory control, and processing of sensory information. Intact cerebello‐parietal communication and increased thalamic connectivity to the prefrontal regions in patients on dopaminergic medication suggests a treatment effect on thalamus. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=148145017 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.14577 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 448 Subjects: – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Restless legs syndrome Type: general – SubjectFull: Functional connectivity Type: general – SubjectFull: Independent component analysis Type: general – SubjectFull: Diagnostic imaging Type: general Titles: – TitleFull: Functional connectivity and topology in patients with restless legs syndrome: a case–control resting‐state functional magnetic resonance imaging study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tuovinen, N. – PersonEntity: Name: NameFull: Stefani, A. – PersonEntity: Name: NameFull: Mitterling, T. – PersonEntity: Name: NameFull: Heidbreder, A. – PersonEntity: Name: NameFull: Frauscher, B. – PersonEntity: Name: NameFull: Gizewski, E. R. – PersonEntity: Name: NameFull: Poewe, W. – PersonEntity: Name: NameFull: Högl, B. – PersonEntity: Name: NameFull: Scherfler, C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 28 – Type: issue Value: 2 Titles: – TitleFull: European Journal of Neurology Type: main |
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