Baseline white matter hyperintensities affect the course of cognitive function after small vessel disease‐related stroke: a prospective observational study.
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| Title: | Baseline white matter hyperintensities affect the course of cognitive function after small vessel disease‐related stroke: a prospective observational study. |
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| Authors: | Fruhwirth, V. (AUTHOR), Enzinger, C. (AUTHOR), Fandler‐Höfler, S. (AUTHOR), Kneihsl, M. (AUTHOR), Eppinger, S. (AUTHOR), Ropele, S. (AUTHOR), Schmidt, R. (AUTHOR), Gattringer, T. (AUTHOR), Pinter, D. (AUTHOR) |
| Source: | European Journal of Neurology. Feb2021, Vol. 28 Issue 2, p401-410. 10p. |
| Subjects: | Cerebral small vessel diseases, White matter (Nerve tissue), Cognitive ability, Magnetic resonance imaging, Longitudinal method, Scientific observation |
| Abstract: | Background and purpose: Cognitive impairment is a common sequel of recent small subcortical infarction (RSSI) and might be negatively affected by preexisting cerebral small vessel disease (SVD). We investigated whether the course of cognitive function in patients with RSSI is influenced by the severity of white matter hyperintensities (WMH), an important imaging feature of SVD. Methods: Patients with magnetic resonance imaging (MRI)‐proven single RSSI were tested neuropsychologically concerning global cognition, processing speed, attention, and set‐shifting. Deep and periventricular WMH severity was assessed using the Fazekas scale, and total WMH lesion volume was calculated from T1‐weighted MRI images. We compared baseline function and course of cognition 15 months after the acute event in patients with absent, mild, and moderate‐to‐severe WMH. Results: The study cohort comprised 82 RSSI patients (mean age: 61 ± 10 years, 23% female). At baseline, 40% had cognitive impairment (1.5 standard deviations below standardized mean), and deficits persisted in one‐third of the sample after 15 months. After age correction, there were no significant differences in set‐shifting between WMH groups at baseline. However, although patients without WMH (deep: p < 0.001, periventricular: p = 0.067) or only mild WMH (deep: p = 0.098, periventricular: p = 0.001) improved in set‐shifting after 15 months, there was no improvement in patients with moderate‐to‐severe WMH (deep: p = 0.980, periventricular: p = 0.816). Baseline total WMH volume (p = 0.002) was the only significant predictor for attention 15 months poststroke. Conclusions: This longitudinal study demonstrates that preexisting moderate‐to‐severe WMH negatively affect the restoration of cognitive function after RSSI, suggesting limited functional reserve in patients with preexisting SVD. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 148145031 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Baseline white matter hyperintensities affect the course of cognitive function after small vessel disease‐related stroke: a prospective observational study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fruhwirth%2C+V%2E%22">Fruhwirth, V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Enzinger%2C+C%2E%22">Enzinger, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fandler‐Höfler%2C+S%2E%22">Fandler‐Höfler, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kneihsl%2C+M%2E%22">Kneihsl, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eppinger%2C+S%2E%22">Eppinger, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ropele%2C+S%2E%22">Ropele, S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmidt%2C+R%2E%22">Schmidt, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gattringer%2C+T%2E%22">Gattringer, T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pinter%2C+D%2E%22">Pinter, D.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Feb2021, Vol. 28 Issue 2, p401-410. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cerebral+small+vessel+diseases%22">Cerebral small vessel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+observation%22">Scientific observation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose: Cognitive impairment is a common sequel of recent small subcortical infarction (RSSI) and might be negatively affected by preexisting cerebral small vessel disease (SVD). We investigated whether the course of cognitive function in patients with RSSI is influenced by the severity of white matter hyperintensities (WMH), an important imaging feature of SVD. Methods: Patients with magnetic resonance imaging (MRI)‐proven single RSSI were tested neuropsychologically concerning global cognition, processing speed, attention, and set‐shifting. Deep and periventricular WMH severity was assessed using the Fazekas scale, and total WMH lesion volume was calculated from T1‐weighted MRI images. We compared baseline function and course of cognition 15 months after the acute event in patients with absent, mild, and moderate‐to‐severe WMH. Results: The study cohort comprised 82 RSSI patients (mean age: 61 ± 10 years, 23% female). At baseline, 40% had cognitive impairment (1.5 standard deviations below standardized mean), and deficits persisted in one‐third of the sample after 15 months. After age correction, there were no significant differences in set‐shifting between WMH groups at baseline. However, although patients without WMH (deep: p < 0.001, periventricular: p = 0.067) or only mild WMH (deep: p = 0.098, periventricular: p = 0.001) improved in set‐shifting after 15 months, there was no improvement in patients with moderate‐to‐severe WMH (deep: p = 0.980, periventricular: p = 0.816). Baseline total WMH volume (p = 0.002) was the only significant predictor for attention 15 months poststroke. Conclusions: This longitudinal study demonstrates that preexisting moderate‐to‐severe WMH negatively affect the restoration of cognitive function after RSSI, suggesting limited functional reserve in patients with preexisting SVD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.14593 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 401 Subjects: – SubjectFull: Cerebral small vessel diseases Type: general – SubjectFull: White matter (Nerve tissue) Type: general – SubjectFull: Cognitive ability Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Longitudinal method Type: general – SubjectFull: Scientific observation Type: general Titles: – TitleFull: Baseline white matter hyperintensities affect the course of cognitive function after small vessel disease‐related stroke: a prospective observational study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fruhwirth, V. – PersonEntity: Name: NameFull: Enzinger, C. – PersonEntity: Name: NameFull: Fandler‐Höfler, S. – PersonEntity: Name: NameFull: Kneihsl, M. – PersonEntity: Name: NameFull: Eppinger, S. – PersonEntity: Name: NameFull: Ropele, S. – PersonEntity: Name: NameFull: Schmidt, R. – PersonEntity: Name: NameFull: Gattringer, T. – PersonEntity: Name: NameFull: Pinter, D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 28 – Type: issue Value: 2 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
