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CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.

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Title: CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.
Authors: Siokas, Vasileios (AUTHOR), Karampinis, Emmanouil (AUTHOR), Aloizou, Athina-Maria (AUTHOR), Mentis, Alexios-Fotios A. (AUTHOR), Liakos, Panagiotis (AUTHOR), Papadimitriou, Dimitra (AUTHOR), Liampas, Ioannis (AUTHOR), Nasios, Grigorios (AUTHOR), Bogdanos, Dimitrios P. (AUTHOR), Hadjigeorgiou, Georgios M. (AUTHOR), Dardiotis, Efthimios (AUTHOR)
Source: Neurological Sciences. 2021, Vol. 42 Issue 1, p175-182. 8p. 6 Charts.
Subjects: Amyotrophic lateral sclerosis, Oxidative stress, Age of onset, Statistical association, Regression analysis
Abstract: Background: Genetic variability is considered to confer susceptibility to amyotrophic lateral sclerosis (ALS). Oxidative stress is a significant contributor to ALS-related neurodegeneration, and it is regulated by cytochromes P450 (CYPs), such as CYP1A2; these are responsible for the oxidative metabolism of both exogenous and endogenous substrates in the brain, subsequently impacting ALS. The function of CYP1A2 is largely affected by genetic variability; however, the impact of CYP1A2 polymorphisms in ALS remains underinvestigated. Objective: This study aims to examine the possible association of ALS with the CYP1A2 rs762551 polymorphism, which codes for the high inducibility form of the enzyme. Methods: One hundred and fifty-five patients with sporadic ALS and 155 healthy controls were genotyped for the CYP1A2 rs762551. Statistical testing for the association of CYP1A2 rs762551 with risk for ALS was performed using SNPstats. Results: The CYP1A2 rs762551 C allele was associated with a decreased risk of ALS development. In the subgroup analysis according to the ALS site of onset, an association between CYP1A2 rs762551 and limb and bulbar onset of ALS was shown. Cox proportional-hazard regression analyses revealed a significant effect of the CYP1A2 rs762551 on the age of onset of ALS. Conclusions: Based on our results, a primarily potential link between the CYP1A2 rs762551 polymorphism and ALS risk could exist. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: CYP1A2 rs762551 polymorphism and risk for amyotrophic lateral sclerosis.
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  Data: <searchLink fieldCode="AR" term="%22Siokas%2C+Vasileios%22">Siokas, Vasileios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Karampinis%2C+Emmanouil%22">Karampinis, Emmanouil</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aloizou%2C+Athina-Maria%22">Aloizou, Athina-Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mentis%2C+Alexios-Fotios+A%2E%22">Mentis, Alexios-Fotios A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liakos%2C+Panagiotis%22">Liakos, Panagiotis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papadimitriou%2C+Dimitra%22">Papadimitriou, Dimitra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liampas%2C+Ioannis%22">Liampas, Ioannis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nasios%2C+Grigorios%22">Nasios, Grigorios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bogdanos%2C+Dimitrios+P%2E%22">Bogdanos, Dimitrios P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hadjigeorgiou%2C+Georgios+M%2E%22">Hadjigeorgiou, Georgios M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dardiotis%2C+Efthimios%22">Dardiotis, Efthimios</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. 2021, Vol. 42 Issue 1, p175-182. 8p. 6 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Age+of+onset%22">Age of onset</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+association%22">Statistical association</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink>
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  Data: Background: Genetic variability is considered to confer susceptibility to amyotrophic lateral sclerosis (ALS). Oxidative stress is a significant contributor to ALS-related neurodegeneration, and it is regulated by cytochromes P450 (CYPs), such as CYP1A2; these are responsible for the oxidative metabolism of both exogenous and endogenous substrates in the brain, subsequently impacting ALS. The function of CYP1A2 is largely affected by genetic variability; however, the impact of CYP1A2 polymorphisms in ALS remains underinvestigated. Objective: This study aims to examine the possible association of ALS with the CYP1A2 rs762551 polymorphism, which codes for the high inducibility form of the enzyme. Methods: One hundred and fifty-five patients with sporadic ALS and 155 healthy controls were genotyped for the CYP1A2 rs762551. Statistical testing for the association of CYP1A2 rs762551 with risk for ALS was performed using SNPstats. Results: The CYP1A2 rs762551 C allele was associated with a decreased risk of ALS development. In the subgroup analysis according to the ALS site of onset, an association between CYP1A2 rs762551 and limb and bulbar onset of ALS was shown. Cox proportional-hazard regression analyses revealed a significant effect of the CYP1A2 rs762551 on the age of onset of ALS. Conclusions: Based on our results, a primarily potential link between the CYP1A2 rs762551 polymorphism and ALS risk could exist. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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