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Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis.

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Title: Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis.
Authors: Yang, Baiyuan (AUTHOR), Yang, Chenghui (AUTHOR), Ren, Junwei (AUTHOR), Zhong, Chengqing (AUTHOR), Liu, Keting (AUTHOR), Zhao, Liusha (AUTHOR), Li, Li (AUTHOR), Wang, Han (AUTHOR), Zhu, Mingling (AUTHOR), Lin, Zhenfang (AUTHOR)
Source: Neurological Sciences. 2021, Vol. 42 Issue 2, p625-631. 7p. 1 Diagram, 2 Charts, 3 Graphs.
Subjects: Amyotrophic lateral sclerosis, Motor neuron diseases, Genes
Abstract: Background: Amyotrophic lateral sclerosis (ALS), one of the motor neuron diseases, appears to be caused by genetic and environmental risk factors. However, the influence of Pro34Ser variant of CHCHD10 gene in increasing risk of ALS remains indeterminate. This study conducted a meta-analysis to establish the association between Pro34Ser variant of CHCHD10 gene and risk of ALS. Methods: PubMed, Web of Science, and Embase databases were systematically searched for genome-wide association studies or case–control studies published up to March 28, 2020, on the association between Pro34Ser variant and risk of ALS. Data from eligible studies were extracted and analyzed. Results: Twelve case–control studies involving 7442 patients with sporadic ALS and 75,371 controls were analyzed. The Pro34Ser variant was not associated with increased risk of ALS disease based on fixed-effects meta-analysis (Pro34Ser-positive vs Pro34Ser-negative: OR 1.23, 95% CI 0.90 to 1.69, P = 0.201). Conclusion: Existing evidence suggests that Pro34Ser variant in CHCHD10 is not associated with risk of ALS, particularly in Caucasian participants. However, our results ought to be validated using large, well-designed studies, especially in Asian and African populations. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis.
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Baiyuan%22">Yang, Baiyuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Chenghui%22">Yang, Chenghui</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ren%2C+Junwei%22">Ren, Junwei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Chengqing%22">Zhong, Chengqing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Keting%22">Liu, Keting</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Liusha%22">Zhao, Liusha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Li%22">Li, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Han%22">Wang, Han</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Mingling%22">Zhu, Mingling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Zhenfang%22">Lin, Zhenfang</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. 2021, Vol. 42 Issue 2, p625-631. 7p. 1 Diagram, 2 Charts, 3 Graphs.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+neuron+diseases%22">Motor neuron diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink>
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  Label: Abstract
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  Data: Background: Amyotrophic lateral sclerosis (ALS), one of the motor neuron diseases, appears to be caused by genetic and environmental risk factors. However, the influence of Pro34Ser variant of CHCHD10 gene in increasing risk of ALS remains indeterminate. This study conducted a meta-analysis to establish the association between Pro34Ser variant of CHCHD10 gene and risk of ALS. Methods: PubMed, Web of Science, and Embase databases were systematically searched for genome-wide association studies or case–control studies published up to March 28, 2020, on the association between Pro34Ser variant and risk of ALS. Data from eligible studies were extracted and analyzed. Results: Twelve case–control studies involving 7442 patients with sporadic ALS and 75,371 controls were analyzed. The Pro34Ser variant was not associated with increased risk of ALS disease based on fixed-effects meta-analysis (Pro34Ser-positive vs Pro34Ser-negative: OR 1.23, 95% CI 0.90 to 1.69, P = 0.201). Conclusion: Existing evidence suggests that Pro34Ser variant in CHCHD10 is not associated with risk of ALS, particularly in Caucasian participants. However, our results ought to be validated using large, well-designed studies, especially in Asian and African populations. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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