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Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls.

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Title: Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls.
Authors: Strehlau, Renate, Burke, Megan, Aswegen, Tamryn, Kuhn, Louise, Potterton, Joanne
Source: Child: Care, Health & Development. Mar2021, Vol. 47 Issue 2, p154-162. 9p. 1 Diagram, 3 Charts.
Subjects: Neural development, Cognitive testing, HIV infections, Motor ability, Health outcome assessment, Sensory stimulation in newborn infants, Antiretroviral agents, Early intervention (Education), Evaluation of human services programs, Children
Geographic Terms: South Africa
Abstract: Background: Neurodevelopmental stimulation programmes can improve developmental outcomes. Antiretroviral therapy (ART) started soon after birth potentially limits the invasion of HIV into the central nervous system. A combination of developmental stimulation and early ART initiation may reduce developmental delays in children with perinatally acquired HIV infection. Methods: At a single site in Johannesburg, South Africa, we enrolled 36 HIV‐infected neonates on ART into an intervention group (IG) participating in a yearlong home‐based, neurodevelopmental stimulation programme. Bayley Scales of Infant and Toddler Development‐3rd Edition (BSID‐III) assessments were conducted at 12 months. Scores were compared with 24 early treated HIV‐infected infants in an observational group (OG). BSID‐III assessments were also conducted for older children in an OG at 24 or 36 months. Cognitive, language and motor scaled and composite scores were analysed. Results: BSID‐III scaled and composite scores were all higher in the IG apart from the gross motor scaled score (9.25 vs. 10, p = 0.1954). Receptive communication scaled score was significantly higher in the IG (10.96 vs. 9, p = 0.0331). IG composite scores were all higher than OG scores. OG children assessed at 24 or 36 months had lower composite scores in all subscales than 12‐month OG scores. Conclusions: Early treated HIV‐infected children participating in a neurodevelopmental stimulation programme achieved higher BSID‐III scores at 12 months compared with early treated HIV‐infected children who did not receive the programme. [ABSTRACT FROM AUTHOR]
Copyright of Child: Care, Health & Development is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls.
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  Data: <searchLink fieldCode="AR" term="%22Strehlau%2C+Renate%22">Strehlau, Renate</searchLink><br /><searchLink fieldCode="AR" term="%22Burke%2C+Megan%22">Burke, Megan</searchLink><br /><searchLink fieldCode="AR" term="%22Aswegen%2C+Tamryn%22">Aswegen, Tamryn</searchLink><br /><searchLink fieldCode="AR" term="%22Kuhn%2C+Louise%22">Kuhn, Louise</searchLink><br /><searchLink fieldCode="AR" term="%22Potterton%2C+Joanne%22">Potterton, Joanne</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Child%3A+Care%2C+Health+%26+Development%22">Child: Care, Health & Development</searchLink>. Mar2021, Vol. 47 Issue 2, p154-162. 9p. 1 Diagram, 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+testing%22">Cognitive testing</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+ability%22">Motor ability</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Sensory+stimulation+in+newborn+infants%22">Sensory stimulation in newborn infants</searchLink><br /><searchLink fieldCode="DE" term="%22Antiretroviral+agents%22">Antiretroviral agents</searchLink><br /><searchLink fieldCode="DE" term="%22Early+intervention+%28Education%29%22">Early intervention (Education)</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+of+human+services+programs%22">Evaluation of human services programs</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22South+Africa%22">South Africa</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Neurodevelopmental stimulation programmes can improve developmental outcomes. Antiretroviral therapy (ART) started soon after birth potentially limits the invasion of HIV into the central nervous system. A combination of developmental stimulation and early ART initiation may reduce developmental delays in children with perinatally acquired HIV infection. Methods: At a single site in Johannesburg, South Africa, we enrolled 36 HIV‐infected neonates on ART into an intervention group (IG) participating in a yearlong home‐based, neurodevelopmental stimulation programme. Bayley Scales of Infant and Toddler Development‐3rd Edition (BSID‐III) assessments were conducted at 12 months. Scores were compared with 24 early treated HIV‐infected infants in an observational group (OG). BSID‐III assessments were also conducted for older children in an OG at 24 or 36 months. Cognitive, language and motor scaled and composite scores were analysed. Results: BSID‐III scaled and composite scores were all higher in the IG apart from the gross motor scaled score (9.25 vs. 10, p = 0.1954). Receptive communication scaled score was significantly higher in the IG (10.96 vs. 9, p = 0.0331). IG composite scores were all higher than OG scores. OG children assessed at 24 or 36 months had lower composite scores in all subscales than 12‐month OG scores. Conclusions: Early treated HIV‐infected children participating in a neurodevelopmental stimulation programme achieved higher BSID‐III scores at 12 months compared with early treated HIV‐infected children who did not receive the programme. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Child: Care, Health & Development is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/cch.12828
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 154
    Subjects:
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Cognitive testing
        Type: general
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: Motor ability
        Type: general
      – SubjectFull: Health outcome assessment
        Type: general
      – SubjectFull: Sensory stimulation in newborn infants
        Type: general
      – SubjectFull: Antiretroviral agents
        Type: general
      – SubjectFull: Early intervention (Education)
        Type: general
      – SubjectFull: Evaluation of human services programs
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: South Africa
        Type: general
    Titles:
      – TitleFull: Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls.
        Type: main
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          Name:
            NameFull: Strehlau, Renate
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            NameFull: Burke, Megan
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            NameFull: Aswegen, Tamryn
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            NameFull: Kuhn, Louise
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            NameFull: Potterton, Joanne
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            – D: 01
              M: 03
              Text: Mar2021
              Type: published
              Y: 2021
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              Value: 03051862
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              Value: 47
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            – TitleFull: Child: Care, Health & Development
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