De novo design of transmembrane β barrels.
Saved in:
| Title: | De novo design of transmembrane β barrels. |
|---|---|
| Authors: | Vorobieva, Anastassia A., White, Paul, Liang, Binyong, Horne, Jim E., Bera, Asim K., Chow, Cameron M., Gerben, Stacey, Marx, Sinduja, Kang, Alex, Stiving, Alyssa Q., Harvey, Sophie R., Marx, Dagan C., Khan, G. Nasir, Fleming, Karen G., Wysocki, Vicki H., Brockwell, David J., Tamm, Lukas K., Radford, Sheena E., Baker, David |
| Source: | Science (pre-March 2025). 2/19/2021, Vol. 371 Issue 6531, p801-801. 1p. 1 Diagram. |
| Subjects: | Membrane proteins, Bilayer lipid membranes, Geometric modeling, Biological membranes, Biological models |
| Abstract: | The article discusses a research article stating that de novo–designed eight-stranded transmembrane beta barrels fold spontaneously and reversibly into synthetic lipid membranes. It mentions that combination of purely geometric models and explicit Rosetta protein structure simulations was used to determine the constraints that beta strand connectivity and membrane embedding place on the transmembrane-beta barrels architecture. |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | The article discusses a research article stating that de novo–designed eight-stranded transmembrane beta barrels fold spontaneously and reversibly into synthetic lipid membranes. It mentions that combination of purely geometric models and explicit Rosetta protein structure simulations was used to determine the constraints that beta strand connectivity and membrane embedding place on the transmembrane-beta barrels architecture. |
|---|---|
| ISSN: | 00368075 |
| DOI: | 10.1126/science.abc8182 |
