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De novo design of transmembrane β barrels.

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Title: De novo design of transmembrane β barrels.
Authors: Vorobieva, Anastassia A., White, Paul, Liang, Binyong, Horne, Jim E., Bera, Asim K., Chow, Cameron M., Gerben, Stacey, Marx, Sinduja, Kang, Alex, Stiving, Alyssa Q., Harvey, Sophie R., Marx, Dagan C., Khan, G. Nasir, Fleming, Karen G., Wysocki, Vicki H., Brockwell, David J., Tamm, Lukas K., Radford, Sheena E., Baker, David
Source: Science (pre-March 2025). 2/19/2021, Vol. 371 Issue 6531, p801-801. 1p. 1 Diagram.
Subjects: Membrane proteins, Bilayer lipid membranes, Geometric modeling, Biological membranes, Biological models
Abstract: The article discusses a research article stating that de novo–designed eight-stranded transmembrane beta barrels fold spontaneously and reversibly into synthetic lipid membranes. It mentions that combination of purely geometric models and explicit Rosetta protein structure simulations was used to determine the constraints that beta strand connectivity and membrane embedding place on the transmembrane-beta barrels architecture.
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 148845677
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: De novo design of transmembrane β barrels.
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  Data: <searchLink fieldCode="AR" term="%22Vorobieva%2C+Anastassia+A%2E%22">Vorobieva, Anastassia A.</searchLink><br /><searchLink fieldCode="AR" term="%22White%2C+Paul%22">White, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Liang%2C+Binyong%22">Liang, Binyong</searchLink><br /><searchLink fieldCode="AR" term="%22Horne%2C+Jim+E%2E%22">Horne, Jim E.</searchLink><br /><searchLink fieldCode="AR" term="%22Bera%2C+Asim+K%2E%22">Bera, Asim K.</searchLink><br /><searchLink fieldCode="AR" term="%22Chow%2C+Cameron+M%2E%22">Chow, Cameron M.</searchLink><br /><searchLink fieldCode="AR" term="%22Gerben%2C+Stacey%22">Gerben, Stacey</searchLink><br /><searchLink fieldCode="AR" term="%22Marx%2C+Sinduja%22">Marx, Sinduja</searchLink><br /><searchLink fieldCode="AR" term="%22Kang%2C+Alex%22">Kang, Alex</searchLink><br /><searchLink fieldCode="AR" term="%22Stiving%2C+Alyssa+Q%2E%22">Stiving, Alyssa Q.</searchLink><br /><searchLink fieldCode="AR" term="%22Harvey%2C+Sophie+R%2E%22">Harvey, Sophie R.</searchLink><br /><searchLink fieldCode="AR" term="%22Marx%2C+Dagan+C%2E%22">Marx, Dagan C.</searchLink><br /><searchLink fieldCode="AR" term="%22Khan%2C+G%2E+Nasir%22">Khan, G. Nasir</searchLink><br /><searchLink fieldCode="AR" term="%22Fleming%2C+Karen+G%2E%22">Fleming, Karen G.</searchLink><br /><searchLink fieldCode="AR" term="%22Wysocki%2C+Vicki+H%2E%22">Wysocki, Vicki H.</searchLink><br /><searchLink fieldCode="AR" term="%22Brockwell%2C+David+J%2E%22">Brockwell, David J.</searchLink><br /><searchLink fieldCode="AR" term="%22Tamm%2C+Lukas+K%2E%22">Tamm, Lukas K.</searchLink><br /><searchLink fieldCode="AR" term="%22Radford%2C+Sheena+E%2E%22">Radford, Sheena E.</searchLink><br /><searchLink fieldCode="AR" term="%22Baker%2C+David%22">Baker, David</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 2/19/2021, Vol. 371 Issue 6531, p801-801. 1p. 1 Diagram.
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  Data: <searchLink fieldCode="DE" term="%22Membrane+proteins%22">Membrane proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Bilayer+lipid+membranes%22">Bilayer lipid membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Geometric+modeling%22">Geometric modeling</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+membranes%22">Biological membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+models%22">Biological models</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article discusses a research article stating that de novo–designed eight-stranded transmembrane beta barrels fold spontaneously and reversibly into synthetic lipid membranes. It mentions that combination of purely geometric models and explicit Rosetta protein structure simulations was used to determine the constraints that beta strand connectivity and membrane embedding place on the transmembrane-beta barrels architecture.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=148845677
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        Value: 10.1126/science.abc8182
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        Text: English
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        StartPage: 801
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        Type: general
      – SubjectFull: Bilayer lipid membranes
        Type: general
      – SubjectFull: Geometric modeling
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      – SubjectFull: Biological membranes
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      – SubjectFull: Biological models
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              Text: 2/19/2021
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              Y: 2021
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