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Estimated model of psychotropic polypharmacy for bipolar disorder: Analysis using patients' and practitioners' parameters in the MUSUBI study.

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Title: Estimated model of psychotropic polypharmacy for bipolar disorder: Analysis using patients' and practitioners' parameters in the MUSUBI study.
Authors: Adachi, Naoto (AUTHOR), Azekawa, Takaharu (AUTHOR), Edagawa, Kouji (AUTHOR), Goto, Eiichiro (AUTHOR), Hongo, Seiji (AUTHOR), Kato, Masaki (AUTHOR), Katsumoto, Eiichi (AUTHOR), Kikuchi, Toshiaki (AUTHOR), Kubota, Yukihisa (AUTHOR), Miki, Kazuhira (AUTHOR), Nakagawa, Atsuo (AUTHOR), Tsuboi, Takashi (AUTHOR), Ueda, Hitoshi (AUTHOR), Watanabe, Koichiro (AUTHOR), Watanabe, Yoichiro (AUTHOR), Yasui‐Furukori, Norio (AUTHOR), Yoshimura, Reiji (AUTHOR)
Source: Human Psychopharmacology: Clinical & Experimental. Mar2021, Vol. 36 Issue 2, p1-8. 8p.
Subjects: Bipolar disorder, Clinics, Social adjustment, Polypharmacy, Aripiprazole, Psychiatric drugs, Multiple regression analysis, Psychiatric clinics
Geographic Terms: Japan
Abstract: Objective: This study aims to clarify the relevant factors influencing practitioners' methods of prescribing medications for bipolar disorder, in a nation‐wide survey in Japan. Methods: The clinical records of 3130 outpatients with bipolar disorder were consecutively reviewed from 176 psychiatric outpatient clinics. Fifteen parameters, that is, five patients' including five general characteristics (sex, age, education, occupation, and social adjustment), five patients' aspects of mental functioning (onset age, comorbid mental illness, rapid‐cycling, psychopathologic severity, and followed‐up years), and five practitioners' characteristics (sex, age, specialist experience, clinic standing years, and location), were evaluated. The number of psychotropic drugs (mood stabilizers, antidepressants, antipsychotic drugs, anxiolytics, and hypnotics) was used as an index of pharmacotherapy. Converted data from each practitioner‐unit were analyzed. Results: Seven factors (patient's social adjustment, patient's psychopathology, patient's comorbid mental disorders, patient's followed‐up years, doctor's age, clinic running years, and patient's education years) were correlated to the number of psychotropic drugs. Multiple regression analysis showed that the severity of illness (poor social adjustment, and comorbid mental illness) and an intractable disease course (long followed‐up years), were significantly associated with the number of psychotropic drugs. Conclusion: Our findings indicated that patient‐related conditions affected psychotropic polypharmacy more strongly than did practitioner‐related conditions. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Estimated model of psychotropic polypharmacy for bipolar disorder: Analysis using patients' and practitioners' parameters in the MUSUBI study.
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  Data: <searchLink fieldCode="AR" term="%22Adachi%2C+Naoto%22">Adachi, Naoto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Azekawa%2C+Takaharu%22">Azekawa, Takaharu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Edagawa%2C+Kouji%22">Edagawa, Kouji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goto%2C+Eiichiro%22">Goto, Eiichiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hongo%2C+Seiji%22">Hongo, Seiji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kato%2C+Masaki%22">Kato, Masaki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Katsumoto%2C+Eiichi%22">Katsumoto, Eiichi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kikuchi%2C+Toshiaki%22">Kikuchi, Toshiaki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kubota%2C+Yukihisa%22">Kubota, Yukihisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Miki%2C+Kazuhira%22">Miki, Kazuhira</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nakagawa%2C+Atsuo%22">Nakagawa, Atsuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsuboi%2C+Takashi%22">Tsuboi, Takashi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ueda%2C+Hitoshi%22">Ueda, Hitoshi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Watanabe%2C+Koichiro%22">Watanabe, Koichiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Watanabe%2C+Yoichiro%22">Watanabe, Yoichiro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yasui‐Furukori%2C+Norio%22">Yasui‐Furukori, Norio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yoshimura%2C+Reiji%22">Yoshimura, Reiji</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Mar2021, Vol. 36 Issue 2, p1-8. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Clinics%22">Clinics</searchLink><br /><searchLink fieldCode="DE" term="%22Social+adjustment%22">Social adjustment</searchLink><br /><searchLink fieldCode="DE" term="%22Polypharmacy%22">Polypharmacy</searchLink><br /><searchLink fieldCode="DE" term="%22Aripiprazole%22">Aripiprazole</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+drugs%22">Psychiatric drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+clinics%22">Psychiatric clinics</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Japan%22">Japan</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This study aims to clarify the relevant factors influencing practitioners' methods of prescribing medications for bipolar disorder, in a nation‐wide survey in Japan. Methods: The clinical records of 3130 outpatients with bipolar disorder were consecutively reviewed from 176 psychiatric outpatient clinics. Fifteen parameters, that is, five patients' including five general characteristics (sex, age, education, occupation, and social adjustment), five patients' aspects of mental functioning (onset age, comorbid mental illness, rapid‐cycling, psychopathologic severity, and followed‐up years), and five practitioners' characteristics (sex, age, specialist experience, clinic standing years, and location), were evaluated. The number of psychotropic drugs (mood stabilizers, antidepressants, antipsychotic drugs, anxiolytics, and hypnotics) was used as an index of pharmacotherapy. Converted data from each practitioner‐unit were analyzed. Results: Seven factors (patient's social adjustment, patient's psychopathology, patient's comorbid mental disorders, patient's followed‐up years, doctor's age, clinic running years, and patient's education years) were correlated to the number of psychotropic drugs. Multiple regression analysis showed that the severity of illness (poor social adjustment, and comorbid mental illness) and an intractable disease course (long followed‐up years), were significantly associated with the number of psychotropic drugs. Conclusion: Our findings indicated that patient‐related conditions affected psychotropic polypharmacy more strongly than did practitioner‐related conditions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/hup.2764
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        Text: English
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      – SubjectFull: Social adjustment
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