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Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients.

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Title: Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients.
Authors: Chen, Xiaoyu (AUTHOR), Wang, Mingqia (AUTHOR), Hu, Yiru (AUTHOR), Zhan, Yanni (AUTHOR), Zhou, Yanling (AUTHOR), Zheng, Wei (AUTHOR), Liu, Weijian (AUTHOR), Wang, Chengyu (AUTHOR), Zhong, Xiaomei (AUTHOR), Li, Hanqiu (AUTHOR), Lan, Xiaofeng (AUTHOR), Ning, Yuping (AUTHOR), Zhang, Bin (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Apr2021, Vol. 271 Issue 3, p431-438. 8p. 1 Diagram, 2 Charts, 1 Graph.
Subjects: Short-term memory, Ketamine, Mental depression, Surgical site infections, Logistic regression analysis, Mental illness
Abstract: Suicide is a tremendous threat to global public health, and a large number of people who committed suicide suffered the pain of mental diseases, especially major depressive disorder (MDD). Previous study showed that ketamine could reduce suicidal ideation (SI), potentially by improving the impaired working memory (WM). The objective of current study was to illuminate the relationship between WM and SI in MDD with repeated ketamine treatment. MDD patients with SI (n = 59) and without SI (n = 37) completed six intravenous infusions of ketamine (0.5 mg/kg over 40 min) over 12 days (Day 1, 3, 5, 8, 10 and 12). The severity of depressive symptoms, SI and WM were assessed at baseline, day 13 and day 26. We found that WM was significantly improved after 6 ketamine infusions (F = 161.284, p = 0.009) in a linear mixed model. Correlation analysis showed that the improvement of depressive symptom was significantly associated with WM at baseline (r = − 0.265, p = 0.042) and the reduction in SSI-part I was related to the change of WM (r = 0.276, p = 0.034) in the MDD patients with SI. Furthermore, Logistic regression analysis showed that improvement in WM might predict the anti-SI response of ketamine. Our findings suggest that the improvement of working memory may partly account for the anti-SI effect of ketamine, and intervention of improving working memory function may be capable of reducing suicidal ideation. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Working memory associated with anti-suicidal ideation effect of repeated-dose intravenous ketamine in depressed patients.
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  Data: <searchLink fieldCode="AR" term="%22Chen%2C+Xiaoyu%22">Chen, Xiaoyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Mingqia%22">Wang, Mingqia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Yiru%22">Hu, Yiru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhan%2C+Yanni%22">Zhan, Yanni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhou%2C+Yanling%22">Zhou, Yanling</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Wei%22">Zheng, Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Weijian%22">Liu, Weijian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Chengyu%22">Wang, Chengyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhong%2C+Xiaomei%22">Zhong, Xiaomei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Hanqiu%22">Li, Hanqiu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lan%2C+Xiaofeng%22">Lan, Xiaofeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ning%2C+Yuping%22">Ning, Yuping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Bin%22">Zhang, Bin</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Apr2021, Vol. 271 Issue 3, p431-438. 8p. 1 Diagram, 2 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Ketamine%22">Ketamine</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+site+infections%22">Surgical site infections</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink>
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  Data: Suicide is a tremendous threat to global public health, and a large number of people who committed suicide suffered the pain of mental diseases, especially major depressive disorder (MDD). Previous study showed that ketamine could reduce suicidal ideation (SI), potentially by improving the impaired working memory (WM). The objective of current study was to illuminate the relationship between WM and SI in MDD with repeated ketamine treatment. MDD patients with SI (n = 59) and without SI (n = 37) completed six intravenous infusions of ketamine (0.5 mg/kg over 40 min) over 12 days (Day 1, 3, 5, 8, 10 and 12). The severity of depressive symptoms, SI and WM were assessed at baseline, day 13 and day 26. We found that WM was significantly improved after 6 ketamine infusions (F = 161.284, p = 0.009) in a linear mixed model. Correlation analysis showed that the improvement of depressive symptom was significantly associated with WM at baseline (r = − 0.265, p = 0.042) and the reduction in SSI-part I was related to the change of WM (r = 0.276, p = 0.034) in the MDD patients with SI. Furthermore, Logistic regression analysis showed that improvement in WM might predict the anti-SI response of ketamine. Our findings suggest that the improvement of working memory may partly account for the anti-SI effect of ketamine, and intervention of improving working memory function may be capable of reducing suicidal ideation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00406-020-01221-z
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        Type: general
      – SubjectFull: Ketamine
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      – SubjectFull: Surgical site infections
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