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Gut Microbiota in Tumor Microenvironment: A Critical Regulator in Cancer Initiation and Development as Potential Targets for Chinese Medicine.

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Title: Gut Microbiota in Tumor Microenvironment: A Critical Regulator in Cancer Initiation and Development as Potential Targets for Chinese Medicine.
Authors: Wang, Li (AUTHOR), Peng, Fu (AUTHOR), Peng, Cheng (AUTHOR), Du, Jun-Rong (AUTHOR)
Source: American Journal of Chinese Medicine. 2021, Vol. 49 Issue 3, p609-626. 18p.
Subjects: Endothelial cells, Herbal medicine, Immune checkpoint inhibitors, Gut microbiota, Inflammation, Cell physiology, Cellular signal transduction, Stem cells, Immunological adjuvants, Tumors, Extracellular space, Cell lines, Degeneration (Pathology), Chinese medicine, Immunotherapy, Therapeutics
Abstract: Cancer is a disease with a high mortality and disability rate. Cancer consists not only of cancer cells, but also of the surrounding microenvironment and tumor microenvironment (TME) constantly interacting with tumor cells to support tumor development and progression. Over the last decade, accumulating evidence has implicated that microbiota profoundly influences cancer initiation and progression. Most research focuses on gut microbiota, for the gut harbors the largest collection of microorganisms. Gut microbiota includes bacteria, viruses, protozoa, archaea, and fungi in the gastrointestinal tract, affecting DNA damage, host immune response and chronic inflammation in various types of cancer (i.e., colon cancer, gastric cancer and breast cancer). Notably, gut dysbiosis can reshape tumor microenvironment and make it favorable for tumor growth. Recently, accumulating studies have attached the importance of traditional Chinese medicine (TCM) to cancer treatments, and the bioactive natural compounds have been considered as potential drug candidates to suppress cancer initiation and development. Interestingly, more recent studies demonstrate that TCM could potentially prevent and suppress early-stage cancer progression through the regulation of gut microbiota. This review is on the purpose of exhausting the significance of gut microbiota in the tumor microenvironment as potential targets of Chinese medicine. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Gut Microbiota in Tumor Microenvironment: A Critical Regulator in Cancer Initiation and Development as Potential Targets for Chinese Medicine.
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  Data: <searchLink fieldCode="AR" term="%22Wang%2C+Li%22">Wang, Li</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peng%2C+Fu%22">Peng, Fu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peng%2C+Cheng%22">Peng, Cheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Du%2C+Jun-Rong%22">Du, Jun-Rong</searchLink> (AUTHOR)
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  Label: Abstract
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  Data: Cancer is a disease with a high mortality and disability rate. Cancer consists not only of cancer cells, but also of the surrounding microenvironment and tumor microenvironment (TME) constantly interacting with tumor cells to support tumor development and progression. Over the last decade, accumulating evidence has implicated that microbiota profoundly influences cancer initiation and progression. Most research focuses on gut microbiota, for the gut harbors the largest collection of microorganisms. Gut microbiota includes bacteria, viruses, protozoa, archaea, and fungi in the gastrointestinal tract, affecting DNA damage, host immune response and chronic inflammation in various types of cancer (i.e., colon cancer, gastric cancer and breast cancer). Notably, gut dysbiosis can reshape tumor microenvironment and make it favorable for tumor growth. Recently, accumulating studies have attached the importance of traditional Chinese medicine (TCM) to cancer treatments, and the bioactive natural compounds have been considered as potential drug candidates to suppress cancer initiation and development. Interestingly, more recent studies demonstrate that TCM could potentially prevent and suppress early-stage cancer progression through the regulation of gut microbiota. This review is on the purpose of exhausting the significance of gut microbiota in the tumor microenvironment as potential targets of Chinese medicine. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1142/S0192415X21500270
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 609
    Subjects:
      – SubjectFull: Endothelial cells
        Type: general
      – SubjectFull: Herbal medicine
        Type: general
      – SubjectFull: Immune checkpoint inhibitors
        Type: general
      – SubjectFull: Gut microbiota
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Cell physiology
        Type: general
      – SubjectFull: Cellular signal transduction
        Type: general
      – SubjectFull: Stem cells
        Type: general
      – SubjectFull: Immunological adjuvants
        Type: general
      – SubjectFull: Tumors
        Type: general
      – SubjectFull: Extracellular space
        Type: general
      – SubjectFull: Cell lines
        Type: general
      – SubjectFull: Degeneration (Pathology)
        Type: general
      – SubjectFull: Chinese medicine
        Type: general
      – SubjectFull: Immunotherapy
        Type: general
      – SubjectFull: Therapeutics
        Type: general
    Titles:
      – TitleFull: Gut Microbiota in Tumor Microenvironment: A Critical Regulator in Cancer Initiation and Development as Potential Targets for Chinese Medicine.
        Type: main
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            NameFull: Wang, Li
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            NameFull: Peng, Fu
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            NameFull: Peng, Cheng
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          Name:
            NameFull: Du, Jun-Rong
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            – D: 01
              M: 03
              Text: 2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 0192415X
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            – Type: volume
              Value: 49
            – Type: issue
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            – TitleFull: American Journal of Chinese Medicine
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