View in EDS

Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death.

Saved in:
Bibliographic Details
Title: Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death.
Authors: Robinson, Andrew C. (AUTHOR), Roncaroli, Federico (AUTHOR), Davidson, Yvonne S. (AUTHOR), Minshull, James (AUTHOR), Heal, Calvin (AUTHOR), Montaldi, Daniela (AUTHOR), Payton, Antony (AUTHOR), Horan, Michael A. (AUTHOR), Pendleton, Neil (AUTHOR), Mann, David M.A. (AUTHOR)
Source: International Journal of Geriatric Psychiatry. May2021, Vol. 36 Issue 5, p713-721. 9p.
Subjects: University of Manchester, Pathology, Alzheimer's disease, Pathological physiology, Geriatric Depression Scale, Cognition disorders
Abstract: Objectives: Early diagnosis of Alzheimer's disease (AD) is essential for early interventions. Symptoms of depression could represent a prodromal stage of AD. Very early mood alterations may help to stratify those at highest risk of late-life AD. We aim to investigate associations between baseline/longitudinal scores for depression, presence of cognitive impairment and/or AD pathology at death.Methods/design: Between 1991 and 2015, participants from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age underwent 10 waves of assessment using the Geriatric Depression Scale (GDS). AD pathology at death was evaluated in 106 eligible cases. Analyses aimed to examine associations between GDS scores, cognitive status and AD pathology (as measured by Braak stage, Thal phase and CERAD).Results: Baseline GDS scores were significantly higher for those cognitively impaired at death than those cognitively normal. Significantly higher baseline GDS scores were found for those with greater Consortium to Establish a Registry for Alzheimer's Disease (CERAD) scores than those with lower CERAD scores. Similarly, significantly higher baseline GDS scores were found for those with a greater Braak stage than those with lower tau burden. These correlations remained after controlling for age at death, education and APOE ε4, but were less robust. Mean longitudinal GDS scores associated with cognition but not pathology.Conclusions: GDS scores collected approximately 20 years before death were associated with cognitive status and AD pathology at death. We postulate that early AD-related pathological change produces raised GDS scores due to an overlapping neural basis with depression, and that this may be considered as an early diagnostic marker for AD. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 149598431
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Robinson%2C+Andrew+C%2E%22">Robinson, Andrew C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roncaroli%2C+Federico%22">Roncaroli, Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Davidson%2C+Yvonne+S%2E%22">Davidson, Yvonne S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Minshull%2C+James%22">Minshull, James</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heal%2C+Calvin%22">Heal, Calvin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Montaldi%2C+Daniela%22">Montaldi, Daniela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Payton%2C+Antony%22">Payton, Antony</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Horan%2C+Michael+A%2E%22">Horan, Michael A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pendleton%2C+Neil%22">Pendleton, Neil</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mann%2C+David+M%2EA%2E%22">Mann, David M.A.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. May2021, Vol. 36 Issue 5, p713-721. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22University+of+Manchester%22">University of Manchester</searchLink><br /><searchLink fieldCode="DE" term="%22Pathology%22">Pathology</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Geriatric+Depression+Scale%22">Geriatric Depression Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Objectives: </bold>Early diagnosis of Alzheimer's disease (AD) is essential for early interventions. Symptoms of depression could represent a prodromal stage of AD. Very early mood alterations may help to stratify those at highest risk of late-life AD. We aim to investigate associations between baseline/longitudinal scores for depression, presence of cognitive impairment and/or AD pathology at death.<bold>Methods/design: </bold>Between 1991 and 2015, participants from The University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age underwent 10 waves of assessment using the Geriatric Depression Scale (GDS). AD pathology at death was evaluated in 106 eligible cases. Analyses aimed to examine associations between GDS scores, cognitive status and AD pathology (as measured by Braak stage, Thal phase and CERAD).<bold>Results: </bold>Baseline GDS scores were significantly higher for those cognitively impaired at death than those cognitively normal. Significantly higher baseline GDS scores were found for those with greater Consortium to Establish a Registry for Alzheimer's Disease (CERAD) scores than those with lower CERAD scores. Similarly, significantly higher baseline GDS scores were found for those with a greater Braak stage than those with lower tau burden. These correlations remained after controlling for age at death, education and APOE ε4, but were less robust. Mean longitudinal GDS scores associated with cognition but not pathology.<bold>Conclusions: </bold>GDS scores collected approximately 20 years before death were associated with cognitive status and AD pathology at death. We postulate that early AD-related pathological change produces raised GDS scores due to an overlapping neural basis with depression, and that this may be considered as an early diagnostic marker for AD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=149598431
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/gps.5470
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 713
    Subjects:
      – SubjectFull: University of Manchester
        Type: general
      – SubjectFull: Pathology
        Type: general
      – SubjectFull: Alzheimer's disease
        Type: general
      – SubjectFull: Pathological physiology
        Type: general
      – SubjectFull: Geriatric Depression Scale
        Type: general
      – SubjectFull: Cognition disorders
        Type: general
    Titles:
      – TitleFull: Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Robinson, Andrew C.
      – PersonEntity:
          Name:
            NameFull: Roncaroli, Federico
      – PersonEntity:
          Name:
            NameFull: Davidson, Yvonne S.
      – PersonEntity:
          Name:
            NameFull: Minshull, James
      – PersonEntity:
          Name:
            NameFull: Heal, Calvin
      – PersonEntity:
          Name:
            NameFull: Montaldi, Daniela
      – PersonEntity:
          Name:
            NameFull: Payton, Antony
      – PersonEntity:
          Name:
            NameFull: Horan, Michael A.
      – PersonEntity:
          Name:
            NameFull: Pendleton, Neil
      – PersonEntity:
          Name:
            NameFull: Mann, David M.A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 08856230
          Numbering:
            – Type: volume
              Value: 36
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: International Journal of Geriatric Psychiatry
              Type: main
ResultId 1