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Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons.

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Title: Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons.
Authors: Reid, Dylan A., Reed, Patrick J., Schlachetzki, Johannes C. M., Nitulescu, Ioana I., Chou, Grace, Tsui, Enoch C., Jones, Jeffrey R., Chandran, Sahaana, Lu, Ake T., McClain, Claire A., Ooi, Jean H., Wang, Tzu-Wen, Lana, Addison J., Linker, Sara B., Ricciardulli, Anthony S., Lau, Shong, Schafer, Simon T., Horvath, Steve, Dixon, Jesse R., Hah, Nasun
Source: Science (pre-March 2025). 4/2/2021, Vol. 371 Issue 6537, p91-94. 4p. 4 Color Photographs.
Subjects: Neurons, DNA replication, RNA-binding proteins, DNA repair, Nucleotide sequencing
Abstract: Neurons are the longest-lived cells in our bodies and lack DNA replication, which makes them reliant on a limited repertoire of DNA repair mechanisms to maintain genome fidelity. These repair mechanisms decline with age, but we have limited knowledge of how genome instability emerges and what strategies neurons and other long-lived cells may have evolved to protect their genomes over the human life span. A targeted sequencing approach in human embryonic stem cellÐinduced neurons shows that, in neurons, DNA repair is enriched at well-defined hotspots that protect essential genes. These hotspots are enriched with histone H2A isoforms and RNA binding proteins and are associated with evolutionarily conserved elements of the human genome. These findings provide a basis for understanding genome integrity as it relates to aging and disease in the nervous system. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons.
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  Data: <searchLink fieldCode="AR" term="%22Reid%2C+Dylan+A%2E%22">Reid, Dylan A.</searchLink><br /><searchLink fieldCode="AR" term="%22Reed%2C+Patrick+J%2E%22">Reed, Patrick J.</searchLink><br /><searchLink fieldCode="AR" term="%22Schlachetzki%2C+Johannes+C%2E+M%2E%22">Schlachetzki, Johannes C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Nitulescu%2C+Ioana+I%2E%22">Nitulescu, Ioana I.</searchLink><br /><searchLink fieldCode="AR" term="%22Chou%2C+Grace%22">Chou, Grace</searchLink><br /><searchLink fieldCode="AR" term="%22Tsui%2C+Enoch+C%2E%22">Tsui, Enoch C.</searchLink><br /><searchLink fieldCode="AR" term="%22Jones%2C+Jeffrey+R%2E%22">Jones, Jeffrey R.</searchLink><br /><searchLink fieldCode="AR" term="%22Chandran%2C+Sahaana%22">Chandran, Sahaana</searchLink><br /><searchLink fieldCode="AR" term="%22Lu%2C+Ake+T%2E%22">Lu, Ake T.</searchLink><br /><searchLink fieldCode="AR" term="%22McClain%2C+Claire+A%2E%22">McClain, Claire A.</searchLink><br /><searchLink fieldCode="AR" term="%22Ooi%2C+Jean+H%2E%22">Ooi, Jean H.</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Tzu-Wen%22">Wang, Tzu-Wen</searchLink><br /><searchLink fieldCode="AR" term="%22Lana%2C+Addison+J%2E%22">Lana, Addison J.</searchLink><br /><searchLink fieldCode="AR" term="%22Linker%2C+Sara+B%2E%22">Linker, Sara B.</searchLink><br /><searchLink fieldCode="AR" term="%22Ricciardulli%2C+Anthony+S%2E%22">Ricciardulli, Anthony S.</searchLink><br /><searchLink fieldCode="AR" term="%22Lau%2C+Shong%22">Lau, Shong</searchLink><br /><searchLink fieldCode="AR" term="%22Schafer%2C+Simon+T%2E%22">Schafer, Simon T.</searchLink><br /><searchLink fieldCode="AR" term="%22Horvath%2C+Steve%22">Horvath, Steve</searchLink><br /><searchLink fieldCode="AR" term="%22Dixon%2C+Jesse+R%2E%22">Dixon, Jesse R.</searchLink><br /><searchLink fieldCode="AR" term="%22Hah%2C+Nasun%22">Hah, Nasun</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 4/2/2021, Vol. 371 Issue 6537, p91-94. 4p. 4 Color Photographs.
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  Data: <searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+replication%22">DNA replication</searchLink><br /><searchLink fieldCode="DE" term="%22RNA-binding+proteins%22">RNA-binding proteins</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+repair%22">DNA repair</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleotide+sequencing%22">Nucleotide sequencing</searchLink>
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  Label: Abstract
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  Data: Neurons are the longest-lived cells in our bodies and lack DNA replication, which makes them reliant on a limited repertoire of DNA repair mechanisms to maintain genome fidelity. These repair mechanisms decline with age, but we have limited knowledge of how genome instability emerges and what strategies neurons and other long-lived cells may have evolved to protect their genomes over the human life span. A targeted sequencing approach in human embryonic stem cellÐinduced neurons shows that, in neurons, DNA repair is enriched at well-defined hotspots that protect essential genes. These hotspots are enriched with histone H2A isoforms and RNA binding proteins and are associated with evolutionarily conserved elements of the human genome. These findings provide a basis for understanding genome integrity as it relates to aging and disease in the nervous system. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=149635959
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        Value: 10.1126/science.abb9032
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        Text: English
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      – SubjectFull: RNA-binding proteins
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