View in EDS

Thrombosis Risk in Transgender Adolescents Receiving Gender-Affirming Hormone Therapy.

Saved in:
Bibliographic Details
Title: Thrombosis Risk in Transgender Adolescents Receiving Gender-Affirming Hormone Therapy.
Authors: Mullins, Eric S., Geer, Rebecca, Metcalf, Megan, Piccola, Jeanne, Lane, Adam, Conard, Lee Ann E., Kowalczyk Mullins, Tanya L.
Source: Pediatrics. Apr2021, Vol. 147 Issue 4, p1-9. 9p.
Subjects: Thrombosis risk factors, Gender affirming care, Hormone therapy, Children's hospitals, Surgical complications, Retrospective studies, Acquisition of data, Disease incidence, Medical records
Abstract: BACKGROUND AND OBJECTIVES: Many transgender youth experience gender dysphoria, a risk factor for suicide. Gender-affirming hormone therapy (GAHT) ameliorates this risk but may increase the risk for thrombosis, as seen from studies in adults. The aim with this study was to examine thrombosis and thrombosis risk factors among an exclusively adolescent and young adult transgender population. METHODS: This retrospective chart review was conducted at a pediatric hospital-associated transgender health clinic. The primary outcome was incidence of arterial or venous thrombosis during GAHT. Secondary measures included the prevalence of thrombosis risk factors. RESULTS: Among 611 participants, 28.8% were transgender women and 68.1% were transgender men. Median age was 17 years at GAHT initiation. Median follow-up time was 554 and 577 days for estrogen and testosterone users, respectively. Individuals starting GAHT had estradiol and testosterone levels titrated to physiologic normal. Multiple thrombotic risk factors were noted among the cohort, including obesity, tobacco use, and personal and family history of thrombosis. Seventeen youth with risk factors for thrombosis were referred for hematologic evaluation. Five individuals were treated with anticoagulation during GAHT: 2 with a previous thrombosis and 3 for thromboprophylaxis. No participant developed thrombosis while on GAHT. CONCLUSIONS: In this study, we examined thrombosis and thrombosis risk factors in an exclusively adolescent and young adult population of transgender people receiving GAHT. These data suggest that GAHT in youth, titrated within physiologic range, does not carry a significant risk of thrombosis in the short-term, even with the presence of preexisting thrombosis risk factors. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 149639988
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Thrombosis Risk in Transgender Adolescents Receiving Gender-Affirming Hormone Therapy.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Mullins%2C+Eric+S%2E%22">Mullins, Eric S.</searchLink><br /><searchLink fieldCode="AR" term="%22Geer%2C+Rebecca%22">Geer, Rebecca</searchLink><br /><searchLink fieldCode="AR" term="%22Metcalf%2C+Megan%22">Metcalf, Megan</searchLink><br /><searchLink fieldCode="AR" term="%22Piccola%2C+Jeanne%22">Piccola, Jeanne</searchLink><br /><searchLink fieldCode="AR" term="%22Lane%2C+Adam%22">Lane, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Conard%2C+Lee+Ann+E%2E%22">Conard, Lee Ann E.</searchLink><br /><searchLink fieldCode="AR" term="%22Kowalczyk+Mullins%2C+Tanya+L%2E%22">Kowalczyk Mullins, Tanya L.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Apr2021, Vol. 147 Issue 4, p1-9. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Thrombosis+risk+factors%22">Thrombosis risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Gender+affirming+care%22">Gender affirming care</searchLink><br /><searchLink fieldCode="DE" term="%22Hormone+therapy%22">Hormone therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Children's+hospitals%22">Children's hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+complications%22">Surgical complications</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Acquisition+of+data%22">Acquisition of data</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+incidence%22">Disease incidence</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND AND OBJECTIVES: Many transgender youth experience gender dysphoria, a risk factor for suicide. Gender-affirming hormone therapy (GAHT) ameliorates this risk but may increase the risk for thrombosis, as seen from studies in adults. The aim with this study was to examine thrombosis and thrombosis risk factors among an exclusively adolescent and young adult transgender population. METHODS: This retrospective chart review was conducted at a pediatric hospital-associated transgender health clinic. The primary outcome was incidence of arterial or venous thrombosis during GAHT. Secondary measures included the prevalence of thrombosis risk factors. RESULTS: Among 611 participants, 28.8% were transgender women and 68.1% were transgender men. Median age was 17 years at GAHT initiation. Median follow-up time was 554 and 577 days for estrogen and testosterone users, respectively. Individuals starting GAHT had estradiol and testosterone levels titrated to physiologic normal. Multiple thrombotic risk factors were noted among the cohort, including obesity, tobacco use, and personal and family history of thrombosis. Seventeen youth with risk factors for thrombosis were referred for hematologic evaluation. Five individuals were treated with anticoagulation during GAHT: 2 with a previous thrombosis and 3 for thromboprophylaxis. No participant developed thrombosis while on GAHT. CONCLUSIONS: In this study, we examined thrombosis and thrombosis risk factors in an exclusively adolescent and young adult population of transgender people receiving GAHT. These data suggest that GAHT in youth, titrated within physiologic range, does not carry a significant risk of thrombosis in the short-term, even with the presence of preexisting thrombosis risk factors. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=149639988
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2020-023549
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 1
    Subjects:
      – SubjectFull: Thrombosis risk factors
        Type: general
      – SubjectFull: Gender affirming care
        Type: general
      – SubjectFull: Hormone therapy
        Type: general
      – SubjectFull: Children's hospitals
        Type: general
      – SubjectFull: Surgical complications
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Disease incidence
        Type: general
      – SubjectFull: Medical records
        Type: general
    Titles:
      – TitleFull: Thrombosis Risk in Transgender Adolescents Receiving Gender-Affirming Hormone Therapy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mullins, Eric S.
      – PersonEntity:
          Name:
            NameFull: Geer, Rebecca
      – PersonEntity:
          Name:
            NameFull: Metcalf, Megan
      – PersonEntity:
          Name:
            NameFull: Piccola, Jeanne
      – PersonEntity:
          Name:
            NameFull: Lane, Adam
      – PersonEntity:
          Name:
            NameFull: Conard, Lee Ann E.
      – PersonEntity:
          Name:
            NameFull: Kowalczyk Mullins, Tanya L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 00314005
          Numbering:
            – Type: volume
              Value: 147
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Pediatrics
              Type: main
ResultId 1