A proof-of-concept study comparing tinnitus and neural connectivity changes following multisensory perceptual training with and without a low-dose of fluoxetine.
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| Title: | A proof-of-concept study comparing tinnitus and neural connectivity changes following multisensory perceptual training with and without a low-dose of fluoxetine. |
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| Authors: | Searchfield, G. D. (AUTHOR), Spiegel, D. P. (AUTHOR), Poppe, T.N.E.R. (AUTHOR), Durai, M. (AUTHOR), Jensen, M. (AUTHOR), Kobayashi, K. (AUTHOR), Park, J. (AUTHOR), Russell, B.R. (AUTHOR), Shekhawat, G. S. (AUTHOR), Sundram, F. (AUTHOR), Thompson, B.B. (AUTHOR), Wise, K. J. (AUTHOR) |
| Source: | International Journal of Neuroscience. May2021, Vol. 131 Issue 5, p433-444. 12p. |
| Subjects: | Functional magnetic resonance imaging, Tinnitus, Fluoxetine, Perceptual learning, Auditory perception |
| Abstract: | Background. This proof-of-concept study investigated a method of multisensory perceptual training for tinnitus, and whether a short, low-dose administration of fluoxetine enhanced training effects and changed neural connectivity. Methods. A double-blind, randomized placebo controlled design with 20 participants (17 male, 3 female, mean age = 57.1 years) involved 30 min daily computer-based, multisensory training (matching visual, auditory and tactile stimuli to perception of tinnitus) for 20 days, and random allocation to take 20 mg fluoxetine or placebo daily. Behavioral measures of tinnitus and correlations between pairs of a priori regions of interest (ROIs), obtained using resting-state functional magnetic resonance imaging (rs-fMRI), were performed before and after the training. Results. Significant changes in ratings of tinnitus loudness, annoyance, and problem were observed with training. No statistically significant changes in Tinnitus Functional Index, Tinnitus Handicap Inventory or Depression Anxiety Stress Scales were found with training. Fluoxetine did not alter any of the behavioural outcomes of training compared to placebo. Significant changes in connectivity between ROIs were identified with training; sensory and attention neural network ROI changes correlated with significant tinnitus rating changes. Rs-fMRI results suggested that the direction of functional connectivity changes between auditory and non-auditory networks, with training and fluoxetine, were opposite to the direction of those changes with multisensory training and placebo. Conclusions. Improvements in tinnitus measures were correlated with changes in sensory and attention networks. The results provide preliminary evidence for changes in rs-fMRI accompanying a multisensory training method in persons with tinnitus. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 150005981 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A proof-of-concept study comparing tinnitus and neural connectivity changes following multisensory perceptual training with and without a low-dose of fluoxetine. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Searchfield%2C+G%2E+D%2E%22">Searchfield, G. D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spiegel%2C+D%2E+P%2E%22">Spiegel, D. P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Poppe%2C+T%2EN%2EE%2ER%2E%22">Poppe, T.N.E.R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Durai%2C+M%2E%22">Durai, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jensen%2C+M%2E%22">Jensen, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kobayashi%2C+K%2E%22">Kobayashi, K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Park%2C+J%2E%22">Park, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Russell%2C+B%2ER%2E%22">Russell, B.R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shekhawat%2C+G%2E+S%2E%22">Shekhawat, G. S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sundram%2C+F%2E%22">Sundram, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thompson%2C+B%2EB%2E%22">Thompson, B.B.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wise%2C+K%2E+J%2E%22">Wise, K. J.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. May2021, Vol. 131 Issue 5, p433-444. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Tinnitus%22">Tinnitus</searchLink><br /><searchLink fieldCode="DE" term="%22Fluoxetine%22">Fluoxetine</searchLink><br /><searchLink fieldCode="DE" term="%22Perceptual+learning%22">Perceptual learning</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+perception%22">Auditory perception</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background. This proof-of-concept study investigated a method of multisensory perceptual training for tinnitus, and whether a short, low-dose administration of fluoxetine enhanced training effects and changed neural connectivity. Methods. A double-blind, randomized placebo controlled design with 20 participants (17 male, 3 female, mean age = 57.1 years) involved 30 min daily computer-based, multisensory training (matching visual, auditory and tactile stimuli to perception of tinnitus) for 20 days, and random allocation to take 20 mg fluoxetine or placebo daily. Behavioral measures of tinnitus and correlations between pairs of a priori regions of interest (ROIs), obtained using resting-state functional magnetic resonance imaging (rs-fMRI), were performed before and after the training. Results. Significant changes in ratings of tinnitus loudness, annoyance, and problem were observed with training. No statistically significant changes in Tinnitus Functional Index, Tinnitus Handicap Inventory or Depression Anxiety Stress Scales were found with training. Fluoxetine did not alter any of the behavioural outcomes of training compared to placebo. Significant changes in connectivity between ROIs were identified with training; sensory and attention neural network ROI changes correlated with significant tinnitus rating changes. Rs-fMRI results suggested that the direction of functional connectivity changes between auditory and non-auditory networks, with training and fluoxetine, were opposite to the direction of those changes with multisensory training and placebo. Conclusions. Improvements in tinnitus measures were correlated with changes in sensory and attention networks. The results provide preliminary evidence for changes in rs-fMRI accompanying a multisensory training method in persons with tinnitus. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00207454.2020.1746310 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 433 Subjects: – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Tinnitus Type: general – SubjectFull: Fluoxetine Type: general – SubjectFull: Perceptual learning Type: general – SubjectFull: Auditory perception Type: general Titles: – TitleFull: A proof-of-concept study comparing tinnitus and neural connectivity changes following multisensory perceptual training with and without a low-dose of fluoxetine. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Searchfield, G. D. – PersonEntity: Name: NameFull: Spiegel, D. P. – PersonEntity: Name: NameFull: Poppe, T.N.E.R. – PersonEntity: Name: NameFull: Durai, M. – PersonEntity: Name: NameFull: Jensen, M. – PersonEntity: Name: NameFull: Kobayashi, K. – PersonEntity: Name: NameFull: Park, J. – PersonEntity: Name: NameFull: Russell, B.R. – PersonEntity: Name: NameFull: Shekhawat, G. S. – PersonEntity: Name: NameFull: Sundram, F. – PersonEntity: Name: NameFull: Thompson, B.B. – PersonEntity: Name: NameFull: Wise, K. J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 131 – Type: issue Value: 5 Titles: – TitleFull: International Journal of Neuroscience Type: main |
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