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Early estradiol exposure masculinizes disease‐relevant behaviors in female mice.

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Title: Early estradiol exposure masculinizes disease‐relevant behaviors in female mice.
Authors: Seiffe, Araceli (AUTHOR), Ramirez, Mauro Federico (AUTHOR), Barrios, Claudio Darío (AUTHOR), Albarrán, María Milagros (AUTHOR), Depino, Amaicha Mara (AUTHOR)
Source: European Journal of Neuroscience. Apr2021, Vol. 53 Issue 8, p2483-2499. 17p. 1 Black and White Photograph, 4 Graphs.
Subjects: Gender differences (Psychology), Sexism, Psychological manifestations of general diseases, Autism in children, Autism spectrum disorders, Estradiol, Precocious puberty
Abstract: Most psychiatric disorders show a sex bias in incidence, symptomatology, and/or response to treatment. Males are more susceptible to neurodevelopmental disorders including autism spectrum disorder and attention‐deficit activity disorder, while women are more prone to major depressive disorder and anxiety disorders after puberty. A striking difference between males and females in humans and other mammals is that males undergo a process of brain masculinization due to the early exposure to gonadal hormones. In rodents, this developmental organization of the brain is essential for adult males to express the appropriate sexual behaviors in the presence of a receptive female. Our goal was to determine whether this process of brain masculinization influences behaviors relevant to psychiatric disorders. To this aim, we studied sex differences and the effect of neonatal 17β‐estradiol benzoate treatment of female mice on different disease‐relevant behaviors. Our analysis includes postnatal behavior, juvenile play, and adult tests for sociability, repetitive behaviors, anxiety, and depression. Our results show that the sex differences observed in exploration, repetitive behaviors, and depression‐related behaviors are largely reduced when females are neonatally treated with 17β‐estradiol benzoate. These results suggest a role of neonatal sex steroids in the development of disease‐relevant behaviors and provide evidence supporting a role for perinatal exposure to estrogens and androgens on the development and manifestation of psychiatric disorders. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Early estradiol exposure masculinizes disease‐relevant behaviors in female mice.
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  Data: <searchLink fieldCode="AR" term="%22Seiffe%2C+Araceli%22">Seiffe, Araceli</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramirez%2C+Mauro+Federico%22">Ramirez, Mauro Federico</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barrios%2C+Claudio+Darío%22">Barrios, Claudio Darío</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Albarrán%2C+María+Milagros%22">Albarrán, María Milagros</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Depino%2C+Amaicha+Mara%22">Depino, Amaicha Mara</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Apr2021, Vol. 53 Issue 8, p2483-2499. 17p. 1 Black and White Photograph, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Gender+differences+%28Psychology%29%22">Gender differences (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Sexism%22">Sexism</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+manifestations+of+general+diseases%22">Psychological manifestations of general diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+in+children%22">Autism in children</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Estradiol%22">Estradiol</searchLink><br /><searchLink fieldCode="DE" term="%22Precocious+puberty%22">Precocious puberty</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Most psychiatric disorders show a sex bias in incidence, symptomatology, and/or response to treatment. Males are more susceptible to neurodevelopmental disorders including autism spectrum disorder and attention‐deficit activity disorder, while women are more prone to major depressive disorder and anxiety disorders after puberty. A striking difference between males and females in humans and other mammals is that males undergo a process of brain masculinization due to the early exposure to gonadal hormones. In rodents, this developmental organization of the brain is essential for adult males to express the appropriate sexual behaviors in the presence of a receptive female. Our goal was to determine whether this process of brain masculinization influences behaviors relevant to psychiatric disorders. To this aim, we studied sex differences and the effect of neonatal 17β‐estradiol benzoate treatment of female mice on different disease‐relevant behaviors. Our analysis includes postnatal behavior, juvenile play, and adult tests for sociability, repetitive behaviors, anxiety, and depression. Our results show that the sex differences observed in exploration, repetitive behaviors, and depression‐related behaviors are largely reduced when females are neonatally treated with 17β‐estradiol benzoate. These results suggest a role of neonatal sex steroids in the development of disease‐relevant behaviors and provide evidence supporting a role for perinatal exposure to estrogens and androgens on the development and manifestation of psychiatric disorders. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.15130
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        Text: English
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        Type: general
      – SubjectFull: Sexism
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      – SubjectFull: Psychological manifestations of general diseases
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      – SubjectFull: Autism in children
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      – SubjectFull: Estradiol
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      – SubjectFull: Precocious puberty
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      – TitleFull: Early estradiol exposure masculinizes disease‐relevant behaviors in female mice.
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            NameFull: Seiffe, Araceli
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            NameFull: Barrios, Claudio Darío
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            NameFull: Albarrán, María Milagros
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            NameFull: Depino, Amaicha Mara
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              Text: Apr2021
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              Y: 2021
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