View in EDS PDF Full Text

Urokinase, CX3CL1, CCL2, TRAIL and IL‐18 induced by interferon‐β treatment.

Saved in:
Bibliographic Details
Title: Urokinase, CX3CL1, CCL2, TRAIL and IL‐18 induced by interferon‐β treatment.
Authors: Zhukovsky, Christina (AUTHOR), Herman, Stephanie (AUTHOR), Wiberg, Anna (AUTHOR), Cunningham, Janet L. (AUTHOR), Kultima, Kim (AUTHOR), Burman, Joachim (AUTHOR)
Source: Acta Neurologica Scandinavica. Jun2021, Vol. 143 Issue 6, p602-607. 6p.
Subjects: Urokinase, Blood proteins, Interferon beta-1a, Interferons
Abstract: Objective: To identify serum proteins associated with MS and affected by interferon beta treatment. Methods: Plasma samples from 29 untreated relapsing‐remitting MS patients and 15 healthy controls were investigated with a multiplexed panel containing 92 proteins related to inflammation. Follow‐up samples were available from 13 patients at 1 and 3 months after initiation of treatment with interferon beta‐1a. Results: Ten proteins were differentially expressed in MS patients. Five of these were altered by treatment with IFN‐β 1a: uPA, CX3CL1, CCL2, TRAIL and IL18. Conclusion: CCL2 and TRAIL were confirmed to be modulated with interferon beta treatment in MS. As novel findings, we now report that uPA and CX3CL1 were differentially expressed in MS and increased after IFN‐beta‐1a treatment. Conflicting results have been reported on how interferon beta affects IL‐18. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 150109266
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Urokinase, CX3CL1, CCL2, TRAIL and IL‐18 induced by interferon‐β treatment.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhukovsky%2C+Christina%22">Zhukovsky, Christina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Herman%2C+Stephanie%22">Herman, Stephanie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wiberg%2C+Anna%22">Wiberg, Anna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cunningham%2C+Janet+L%2E%22">Cunningham, Janet L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kultima%2C+Kim%22">Kultima, Kim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burman%2C+Joachim%22">Burman, Joachim</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Jun2021, Vol. 143 Issue 6, p602-607. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Urokinase%22">Urokinase</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+proteins%22">Blood proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Interferon+beta-1a%22">Interferon beta-1a</searchLink><br /><searchLink fieldCode="DE" term="%22Interferons%22">Interferons</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: To identify serum proteins associated with MS and affected by interferon beta treatment. Methods: Plasma samples from 29 untreated relapsing‐remitting MS patients and 15 healthy controls were investigated with a multiplexed panel containing 92 proteins related to inflammation. Follow‐up samples were available from 13 patients at 1 and 3 months after initiation of treatment with interferon beta‐1a. Results: Ten proteins were differentially expressed in MS patients. Five of these were altered by treatment with IFN‐β 1a: uPA, CX3CL1, CCL2, TRAIL and IL18. Conclusion: CCL2 and TRAIL were confirmed to be modulated with interferon beta treatment in MS. As novel findings, we now report that uPA and CX3CL1 were differentially expressed in MS and increased after IFN‐beta‐1a treatment. Conflicting results have been reported on how interferon beta affects IL‐18. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=150109266
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ane.13400
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 602
    Subjects:
      – SubjectFull: Urokinase
        Type: general
      – SubjectFull: Blood proteins
        Type: general
      – SubjectFull: Interferon beta-1a
        Type: general
      – SubjectFull: Interferons
        Type: general
    Titles:
      – TitleFull: Urokinase, CX3CL1, CCL2, TRAIL and IL‐18 induced by interferon‐β treatment.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhukovsky, Christina
      – PersonEntity:
          Name:
            NameFull: Herman, Stephanie
      – PersonEntity:
          Name:
            NameFull: Wiberg, Anna
      – PersonEntity:
          Name:
            NameFull: Cunningham, Janet L.
      – PersonEntity:
          Name:
            NameFull: Kultima, Kim
      – PersonEntity:
          Name:
            NameFull: Burman, Joachim
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 00016314
          Numbering:
            – Type: volume
              Value: 143
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Acta Neurologica Scandinavica
              Type: main
ResultId 1