Myopia and glaucoma progression among patients with juvenile onset open angle glaucoma: A retrospective follow up study.
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| Title: | Myopia and glaucoma progression among patients with juvenile onset open angle glaucoma: A retrospective follow up study. |
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| Authors: | Gupta, Shikha (AUTHOR), Singh, Abhishek (AUTHOR), Mahalingam, Karthikeyan (AUTHOR), Selvan, Harathy (AUTHOR), Gupta, Prasad (AUTHOR), Pandey, Shivam (AUTHOR), Somarajan, Bindu I (AUTHOR), Gupta, Viney (AUTHOR) |
| Source: | Ophthalmic & Physiological Optics. May2021, Vol. 41 Issue 3, p475-485. 11p. 7 Charts, 1 Graph. |
| Subjects: | Open-angle glaucoma, Myopia, Follow-up studies (Medicine), Visual fields, Scanning laser ophthalmoscopy, Glaucoma, Refractive errors |
| Abstract: | Objective: To identify the risk factors for glaucoma progression, especially the association with myopia, among treated juvenile open angle glaucoma (JOAG) patients. Methods: Glaucomatous progression was analysed in the eyes of JOAG patients with at least 5‐years of follow up in this retrospective study. Baseline variables such as age, inheritance pattern, baseline intraocular pressure (IOP), baseline central corneal thickness, visual acuity, baseline refractive error, spherical equivalent (SE) and duration of follow‐up were noted. Stereoparametric global trend analysis and Moorfields Regression Analysis on confocal scanning laser ophthalmoscopy were used to detect progression. Variables associated with glaucoma progression, with respect to progressors (PG) and non‐progressors (NPG) were analysed. Since both eyes of a patient were taken for analysis, a generalised estimating equation method was used to correct the bias. Results: Among 74 eyes (37 subjects), glaucoma progression was noted in 11 eyes (14.9%) of 8 patients, with a median time to progression of 7.4 years (range 5–15.5 years). For myopes (SE ≤ −1.00 D), glaucoma progression was 18 times more likely than mild and no myopes (>‐1DS) (p = 0.03, 95% CI: 1.14, 217.44). The prevalence of myopia in the JOAG, PG and NPG cohorts was 70.3%, 87.5%, and 65.5%, respectively. Myopia progression was noted at follow up in 70% patients. One‐unit increase in baseline vertical cup disc ratio, 1 mmHg increase in IOP fluctuations and 1 dB year−1 depression of visual field were associated with 0.44, 0.06 and 0.07 D year−1 increases in the rate of myopia progression, respectively. Conclusions: JOAG progressors had a greater baseline myopic refraction and a faster myopia development over time. The development of myopia in JOAG eyes could be an indicator of glaucoma progression, and hence progressing myopic (≤−1 D) JOAG patients should be followed up more rigorously. [ABSTRACT FROM AUTHOR] |
| Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 150186653 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Myopia and glaucoma progression among patients with juvenile onset open angle glaucoma: A retrospective follow up study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gupta%2C+Shikha%22">Gupta, Shikha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+Abhishek%22">Singh, Abhishek</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mahalingam%2C+Karthikeyan%22">Mahalingam, Karthikeyan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Selvan%2C+Harathy%22">Selvan, Harathy</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta%2C+Prasad%22">Gupta, Prasad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pandey%2C+Shivam%22">Pandey, Shivam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Somarajan%2C+Bindu+I%22">Somarajan, Bindu I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta%2C+Viney%22">Gupta, Viney</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Ophthalmic+%26+Physiological+Optics%22">Ophthalmic & Physiological Optics</searchLink>. May2021, Vol. 41 Issue 3, p475-485. 11p. 7 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Open-angle+glaucoma%22">Open-angle glaucoma</searchLink><br /><searchLink fieldCode="DE" term="%22Myopia%22">Myopia</searchLink><br /><searchLink fieldCode="DE" term="%22Follow-up+studies+%28Medicine%29%22">Follow-up studies (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+fields%22">Visual fields</searchLink><br /><searchLink fieldCode="DE" term="%22Scanning+laser+ophthalmoscopy%22">Scanning laser ophthalmoscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Glaucoma%22">Glaucoma</searchLink><br /><searchLink fieldCode="DE" term="%22Refractive+errors%22">Refractive errors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: To identify the risk factors for glaucoma progression, especially the association with myopia, among treated juvenile open angle glaucoma (JOAG) patients. Methods: Glaucomatous progression was analysed in the eyes of JOAG patients with at least 5‐years of follow up in this retrospective study. Baseline variables such as age, inheritance pattern, baseline intraocular pressure (IOP), baseline central corneal thickness, visual acuity, baseline refractive error, spherical equivalent (SE) and duration of follow‐up were noted. Stereoparametric global trend analysis and Moorfields Regression Analysis on confocal scanning laser ophthalmoscopy were used to detect progression. Variables associated with glaucoma progression, with respect to progressors (PG) and non‐progressors (NPG) were analysed. Since both eyes of a patient were taken for analysis, a generalised estimating equation method was used to correct the bias. Results: Among 74 eyes (37 subjects), glaucoma progression was noted in 11 eyes (14.9%) of 8 patients, with a median time to progression of 7.4 years (range 5–15.5 years). For myopes (SE ≤ −1.00 D), glaucoma progression was 18 times more likely than mild and no myopes (>‐1DS) (p = 0.03, 95% CI: 1.14, 217.44). The prevalence of myopia in the JOAG, PG and NPG cohorts was 70.3%, 87.5%, and 65.5%, respectively. Myopia progression was noted at follow up in 70% patients. One‐unit increase in baseline vertical cup disc ratio, 1 mmHg increase in IOP fluctuations and 1 dB year−1 depression of visual field were associated with 0.44, 0.06 and 0.07 D year−1 increases in the rate of myopia progression, respectively. Conclusions: JOAG progressors had a greater baseline myopic refraction and a faster myopia development over time. The development of myopia in JOAG eyes could be an indicator of glaucoma progression, and hence progressing myopic (≤−1 D) JOAG patients should be followed up more rigorously. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/opo.12805 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 475 Subjects: – SubjectFull: Open-angle glaucoma Type: general – SubjectFull: Myopia Type: general – SubjectFull: Follow-up studies (Medicine) Type: general – SubjectFull: Visual fields Type: general – SubjectFull: Scanning laser ophthalmoscopy Type: general – SubjectFull: Glaucoma Type: general – SubjectFull: Refractive errors Type: general Titles: – TitleFull: Myopia and glaucoma progression among patients with juvenile onset open angle glaucoma: A retrospective follow up study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gupta, Shikha – PersonEntity: Name: NameFull: Singh, Abhishek – PersonEntity: Name: NameFull: Mahalingam, Karthikeyan – PersonEntity: Name: NameFull: Selvan, Harathy – PersonEntity: Name: NameFull: Gupta, Prasad – PersonEntity: Name: NameFull: Pandey, Shivam – PersonEntity: Name: NameFull: Somarajan, Bindu I – PersonEntity: Name: NameFull: Gupta, Viney IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 02755408 Numbering: – Type: volume Value: 41 – Type: issue Value: 3 Titles: – TitleFull: Ophthalmic & Physiological Optics Type: main |
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