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Muddying the waters? A false positive case of autoimmune psychosis.

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Title: Muddying the waters? A false positive case of autoimmune psychosis.
Authors: Ketheesan, Sarangan (AUTHOR), Bertram, Georgia (AUTHOR), Adam, Robert (AUTHOR), Stark, Anne (AUTHOR), Scott, James G (AUTHOR)
Source: Australasian Psychiatry. Jun2021, Vol. 29 Issue 3, p278-281. 4p.
Subjects: Antibody titer, Medical research, Psychoses, Diagnosis, Symptoms
Abstract: Objective: To discuss challenges with the diagnosis of autoimmune psychosis (AP) in people with chronic psychotic disorders.Method: We present a case of a 23-year-old man with an exacerbation of treatment-refractory psychosis after receiving intravenous immunoglobulin (IVIG) for suspected AP, diagnosed 4 years after the onset of psychosis. We highlight the diagnostic and management challenges in such cases.Results: The diagnosis of AP in people with long-standing illness relies on the interpretation of non-specific clinical and laboratory findings in individuals with psychosocial problems and challenges of acceptance and adherence to complex medical investigations and treatments. Equivocal results from investigations undertaken without logical clinical reasoning can lead to inappropriate interventions that are costly and can cause iatrogenic harm.Conclusion: Psychiatrists should restrict screening for antineuronal antibodies in people with chronic psychosis to those with higher risk features such as persistent treatment refractory symptoms with concurrent neurological signs and symptoms. Further research informing the clinical circumstances for antineuronal antibody testing is needed. [ABSTRACT FROM AUTHOR]
Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Muddying the waters? A false positive case of autoimmune psychosis.
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  Data: <searchLink fieldCode="AR" term="%22Ketheesan%2C+Sarangan%22">Ketheesan, Sarangan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bertram%2C+Georgia%22">Bertram, Georgia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adam%2C+Robert%22">Adam, Robert</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stark%2C+Anne%22">Stark, Anne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scott%2C+James+G%22">Scott, James G</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Australasian+Psychiatry%22">Australasian Psychiatry</searchLink>. Jun2021, Vol. 29 Issue 3, p278-281. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Antibody+titer%22">Antibody titer</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Objective: </bold>To discuss challenges with the diagnosis of autoimmune psychosis (AP) in people with chronic psychotic disorders.<bold>Method: </bold>We present a case of a 23-year-old man with an exacerbation of treatment-refractory psychosis after receiving intravenous immunoglobulin (IVIG) for suspected AP, diagnosed 4 years after the onset of psychosis. We highlight the diagnostic and management challenges in such cases.<bold>Results: </bold>The diagnosis of AP in people with long-standing illness relies on the interpretation of non-specific clinical and laboratory findings in individuals with psychosocial problems and challenges of acceptance and adherence to complex medical investigations and treatments. Equivocal results from investigations undertaken without logical clinical reasoning can lead to inappropriate interventions that are costly and can cause iatrogenic harm.<bold>Conclusion: </bold>Psychiatrists should restrict screening for antineuronal antibodies in people with chronic psychosis to those with higher risk features such as persistent treatment refractory symptoms with concurrent neurological signs and symptoms. Further research informing the clinical circumstances for antineuronal antibody testing is needed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=150635592
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        Value: 10.1177/1039856220965041
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      – Code: eng
        Text: English
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      – SubjectFull: Antibody titer
        Type: general
      – SubjectFull: Medical research
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      – SubjectFull: Psychoses
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      – SubjectFull: Symptoms
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            NameFull: Scott, James G
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            – D: 01
              M: 06
              Text: Jun2021
              Type: published
              Y: 2021
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