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Characteristics and Outcomes in Head and Neck Sarcomatoid Squamous Cell Carcinoma: The Cleveland Clinic Experience.

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Title: Characteristics and Outcomes in Head and Neck Sarcomatoid Squamous Cell Carcinoma: The Cleveland Clinic Experience.
Authors: Mingo, Katie M., Derakhshan, Adeeb, Abdullah, Neelab, Chute, Deborah J., Koyfman, Shlomo A., Lamarre, Eric D., Burkey, Brian B.
Source: Annals of Otology, Rhinology & Laryngology. Jul2021, Vol. 130 Issue 7, p818-824. 7p.
Subjects: Head & neck cancer diagnosis, Head & neck cancer treatment, Statistics, Survival, Acquisition of data methodology, Confidence intervals, Head & neck cancer, Retrospective studies, Tertiary care, Cancer relapse, Metastasis, Treatment effectiveness, Cancer patients, Medical records, Descriptive statistics, Smoking, Squamous cell carcinoma
Geographic Terms: Ohio
Abstract: Objectives: To analyze characteristics, treatment outcomes, and prognostic factors of sarcomatoid squamous cell carcinoma of the head and neck. Study Design: Retrospective chart review. Setting: Tertiary care center. Subjects and Methods: Fifty-five patients were treated for sarcomatoid squamous cell carcinoma of the head and neck between 1996 and 2018. Data collection included clinical history, tumor characteristics, pathology, treatment modality, and outcomes. Mean follow up was 17.1 months. Cox univariate analysis was used to evaluate for associations with locoregional recurrence, distant metastasis, and overall survival. Results: Most patients were white males with a smoking history and median age 66 years (range 41-92) at diagnosis. Twenty-two percent had prior head and neck radiation. Tumor site was most frequently oral cavity (41.8%), followed by larynx (29.1%), and oropharynx (16.4%). Half presented with early T stage disease (15.5% T0, 12.7% T1, 30.9% T2) and the remainder with late stage disease (16.4% T3, 34.5% T4). Locoregional recurrence rate was 60.0%, metastatic recurrence was rate 21.8%, with median time to recurrence of 4 months and mean overall survival of 20 months. Presence of lymphovascular space invasion was statistically associated with locoregional recurrence (P =.018, HR 3.55 [95% CI 1.24, 10.14]) and poorer overall survival (P =.015, HR 2.92 [95% CI 1.23, 4.80]). Treatment with multimodality therapy was associated with decreased locoregional recurrence (P =.039, HR 0.39 [95% CI 0.16, 0.95]) but did not impact overall survival. Conclusion: Sarcomatoid squamous cell carcinoma remains a rare and aggressive disease variant with high recurrence rates and high mortality. High risk features such as lymphovascular space may indicate the need for more aggressive therapy. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Characteristics and Outcomes in Head and Neck Sarcomatoid Squamous Cell Carcinoma: The Cleveland Clinic Experience.
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  Data: <searchLink fieldCode="AR" term="%22Mingo%2C+Katie+M%2E%22">Mingo, Katie M.</searchLink><br /><searchLink fieldCode="AR" term="%22Derakhshan%2C+Adeeb%22">Derakhshan, Adeeb</searchLink><br /><searchLink fieldCode="AR" term="%22Abdullah%2C+Neelab%22">Abdullah, Neelab</searchLink><br /><searchLink fieldCode="AR" term="%22Chute%2C+Deborah+J%2E%22">Chute, Deborah J.</searchLink><br /><searchLink fieldCode="AR" term="%22Koyfman%2C+Shlomo+A%2E%22">Koyfman, Shlomo A.</searchLink><br /><searchLink fieldCode="AR" term="%22Lamarre%2C+Eric+D%2E%22">Lamarre, Eric D.</searchLink><br /><searchLink fieldCode="AR" term="%22Burkey%2C+Brian+B%2E%22">Burkey, Brian B.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Otology%2C+Rhinology+%26+Laryngology%22">Annals of Otology, Rhinology & Laryngology</searchLink>. Jul2021, Vol. 130 Issue 7, p818-824. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Head+%26+neck+cancer+diagnosis%22">Head & neck cancer diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Head+%26+neck+cancer+treatment%22">Head & neck cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Survival%22">Survival</searchLink><br /><searchLink fieldCode="DE" term="%22Acquisition+of+data+methodology%22">Acquisition of data methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Head+%26+neck+cancer%22">Head & neck cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Tertiary+care%22">Tertiary care</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+relapse%22">Cancer relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Metastasis%22">Metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br /><searchLink fieldCode="DE" term="%22Squamous+cell+carcinoma%22">Squamous cell carcinoma</searchLink>
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  Label: Abstract
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  Data: Objectives: To analyze characteristics, treatment outcomes, and prognostic factors of sarcomatoid squamous cell carcinoma of the head and neck. Study Design: Retrospective chart review. Setting: Tertiary care center. Subjects and Methods: Fifty-five patients were treated for sarcomatoid squamous cell carcinoma of the head and neck between 1996 and 2018. Data collection included clinical history, tumor characteristics, pathology, treatment modality, and outcomes. Mean follow up was 17.1 months. Cox univariate analysis was used to evaluate for associations with locoregional recurrence, distant metastasis, and overall survival. Results: Most patients were white males with a smoking history and median age 66 years (range 41-92) at diagnosis. Twenty-two percent had prior head and neck radiation. Tumor site was most frequently oral cavity (41.8%), followed by larynx (29.1%), and oropharynx (16.4%). Half presented with early T stage disease (15.5% T0, 12.7% T1, 30.9% T2) and the remainder with late stage disease (16.4% T3, 34.5% T4). Locoregional recurrence rate was 60.0%, metastatic recurrence was rate 21.8%, with median time to recurrence of 4 months and mean overall survival of 20 months. Presence of lymphovascular space invasion was statistically associated with locoregional recurrence (P =.018, HR 3.55 [95% CI 1.24, 10.14]) and poorer overall survival (P =.015, HR 2.92 [95% CI 1.23, 4.80]). Treatment with multimodality therapy was associated with decreased locoregional recurrence (P =.039, HR 0.39 [95% CI 0.16, 0.95]) but did not impact overall survival. Conclusion: Sarcomatoid squamous cell carcinoma remains a rare and aggressive disease variant with high recurrence rates and high mortality. High risk features such as lymphovascular space may indicate the need for more aggressive therapy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1177/0003489420977778
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        Text: English
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        PageCount: 7
        StartPage: 818
    Subjects:
      – SubjectFull: Head & neck cancer diagnosis
        Type: general
      – SubjectFull: Head & neck cancer treatment
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Survival
        Type: general
      – SubjectFull: Acquisition of data methodology
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Head & neck cancer
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      – SubjectFull: Retrospective studies
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      – SubjectFull: Cancer relapse
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      – SubjectFull: Metastasis
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Cancer patients
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      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Smoking
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      – SubjectFull: Squamous cell carcinoma
        Type: general
      – SubjectFull: Ohio
        Type: general
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      – TitleFull: Characteristics and Outcomes in Head and Neck Sarcomatoid Squamous Cell Carcinoma: The Cleveland Clinic Experience.
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              Text: Jul2021
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              Y: 2021
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