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Characterization of chronic active multiple sclerosis lesions with sodium (23Na) magnetic resonance imaging—preliminary observations.

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Title: Characterization of chronic active multiple sclerosis lesions with sodium (23Na) magnetic resonance imaging—preliminary observations.
Authors: Eisele, Philipp (AUTHOR), Kraemer, Matthias (AUTHOR), Dabringhaus, Andreas (AUTHOR), Weber, Claudia E. (AUTHOR), Ebert, Anne (AUTHOR), Platten, Michael (AUTHOR), Schad, Lothar R. (AUTHOR), Gass, Achim (AUTHOR)
Source: European Journal of Neurology. Jul2021, Vol. 28 Issue 7, p2392-2395. 4p.
Subjects: Magnetic resonance imaging, Multiple sclerosis, Sodium, Tissue viability, Biomarkers
Abstract: Background and purpose: There has been an increasing interest in chronic active multiple sclerosis (MS) lesions as a new magnetic resonance imaging (MRI) marker of disease progression. Chronic active lesions are characterized by progressive tissue matrix damage, axonal loss and chronic inflammation. Sodium (23Na) MRI provides a biochemical marker of cell integrity and tissue viability in a quantitative manner. The aim of this study was to investigate with 23Na MRI tissue abnormalities in chronic active lesions as indicators of tissue destruction. Methods: To identify chronic active lesions, two 3D magnetization‐prepared rapid acquisition gradient‐echo datasets obtained 12 months apart were processed using the voxel‐guided morphometry algorithm. Cross‐sectional 23Na MRI was performed during the 12‐month follow‐up period. Total sodium concentration was calculated in chronic active lesions compared to shrinking, chronic stable and acute contrast‐enhancing lesions. Results: Overall, 70 MS lesions (21 chronic active, 10 shrinking, 29 chronic stable lesions, 10 acute contrast‐enhancing lesions) in 12 patients were included. Total sodium concentration in chronic active lesions (49.57 ± 8.47 mM) was significantly higher than in shrinking (42.16 ± 3.9 mM; p = 0.03) and chronic stable lesions (39.92 ± 4.82 mM; p < 0.001). Chronic active lesions showed similar sodium values compared to acute contrast‐enhancing lesions (48.06 ± 6.65 mM; p = 0.97). No differences between shrinking and chronic stable lesions were observed (p = 0.89). Conclusion: High sodium values in chronic active MS lesions may be an indicator of ongoing inflammation and tissue damage. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Characterization of chronic active multiple sclerosis lesions with sodium (&lt;superscript&gt;23&lt;/superscript&gt;Na) magnetic resonance imaging—preliminary observations.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Eisele%2C+Philipp%22&quot;&gt;Eisele, Philipp&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kraemer%2C+Matthias%22&quot;&gt;Kraemer, Matthias&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dabringhaus%2C+Andreas%22&quot;&gt;Dabringhaus, Andreas&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Weber%2C+Claudia+E%2E%22&quot;&gt;Weber, Claudia E.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ebert%2C+Anne%22&quot;&gt;Ebert, Anne&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Platten%2C+Michael%22&quot;&gt;Platten, Michael&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schad%2C+Lothar+R%2E%22&quot;&gt;Schad, Lothar R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gass%2C+Achim%22&quot;&gt;Gass, Achim&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Jul2021, Vol. 28 Issue 7, p2392-2395. 4p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging%22&quot;&gt;Magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Multiple+sclerosis%22&quot;&gt;Multiple sclerosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sodium%22&quot;&gt;Sodium&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Tissue+viability%22&quot;&gt;Tissue viability&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biomarkers%22&quot;&gt;Biomarkers&lt;/searchLink&gt;
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  Data: Background and purpose: There has been an increasing interest in chronic active multiple sclerosis (MS) lesions as a new magnetic resonance imaging (MRI) marker of disease progression. Chronic active lesions are characterized by progressive tissue matrix damage, axonal loss and chronic inflammation. Sodium (23Na) MRI provides a biochemical marker of cell integrity and tissue viability in a quantitative manner. The aim of this study was to investigate with 23Na MRI tissue abnormalities in chronic active lesions as indicators of tissue destruction. Methods: To identify chronic active lesions, two 3D magnetization‐prepared rapid acquisition gradient‐echo datasets obtained 12 months apart were processed using the voxel‐guided morphometry algorithm. Cross‐sectional 23Na MRI was performed during the 12‐month follow‐up period. Total sodium concentration was calculated in chronic active lesions compared to shrinking, chronic stable and acute contrast‐enhancing lesions. Results: Overall, 70 MS lesions (21 chronic active, 10 shrinking, 29 chronic stable lesions, 10 acute contrast‐enhancing lesions) in 12 patients were included. Total sodium concentration in chronic active lesions (49.57 &#177; 8.47 mM) was significantly higher than in shrinking (42.16 &#177; 3.9 mM; p = 0.03) and chronic stable lesions (39.92 &#177; 4.82 mM; p &lt; 0.001). Chronic active lesions showed similar sodium values compared to acute contrast‐enhancing lesions (48.06 &#177; 6.65 mM; p = 0.97). No differences between shrinking and chronic stable lesions were observed (p = 0.89). Conclusion: High sodium values in chronic active MS lesions may be an indicator of ongoing inflammation and tissue damage. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1111/ene.14873
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        Text: English
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        PageCount: 4
        StartPage: 2392
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      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Multiple sclerosis
        Type: general
      – SubjectFull: Sodium
        Type: general
      – SubjectFull: Tissue viability
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      – SubjectFull: Biomarkers
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      – TitleFull: Characterization of chronic active multiple sclerosis lesions with sodium (23Na) magnetic resonance imaging—preliminary observations.
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              Text: Jul2021
              Type: published
              Y: 2021
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