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BDNF influences neural cue-reactivity to food stimuli and food craving in obesity.

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Title: BDNF influences neural cue-reactivity to food stimuli and food craving in obesity.
Authors: Bumb, Jan Malte (AUTHOR), Bach, Patrick (AUTHOR), Grosshans, Martin (AUTHOR), Wagner, Xenija (AUTHOR), Koopmann, Anne (AUTHOR), Vollstädt-Klein, Sabine (AUTHOR), Schuster, Rilana (AUTHOR), Wiedemann, Klaus (AUTHOR), Kiefer, Falk (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Aug2021, Vol. 271 Issue 5, p963-974. 12p. 2 Charts, 2 Graphs.
Subjects: Obesity, Brain-derived neurotrophic factor, Functional magnetic resonance imaging, Desire
Abstract: There is increasing evidence that brain-derived neurotrophic factor (BDNF) impacts on the development of obesity. We are the first to test the hypothesis that BDNF levels might be associated with neural reactivity to food cues in patients suffering from obesity and healthy controls. We assessed visual food cue-induced neural response in 19 obese patients and 20 matched controls using functional magnetic resonance imaging and analyzed the associations between BDNF levels, food cue-reactivity and food craving. Whole-brain analysis in both groups revealed that food cues elicited higher neural activation in clusters of mesolimbic brain areas including the insula (food > neutral). Patients suffering from obesity showed a significant positive correlation between plasma BDNF levels and visual food cue-reactivity in the bilateral insulae. In addition, patients suffering from obesity with positive food cue-induced insula activation also reported significantly higher food craving than those with low cue-reactivity—an effect that was absent in normal weight participants. The present findings implicate that BDNF levels in patients suffering from obesity might be involved in food craving and obesity in humans. This highlights the importance to consider BDNF pathways when investigating obesity and obesity treatment. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: BDNF influences neural cue-reactivity to food stimuli and food craving in obesity.
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  Data: <searchLink fieldCode="AR" term="%22Bumb%2C+Jan+Malte%22">Bumb, Jan Malte</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bach%2C+Patrick%22">Bach, Patrick</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grosshans%2C+Martin%22">Grosshans, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wagner%2C+Xenija%22">Wagner, Xenija</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koopmann%2C+Anne%22">Koopmann, Anne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vollstädt-Klein%2C+Sabine%22">Vollstädt-Klein, Sabine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schuster%2C+Rilana%22">Schuster, Rilana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wiedemann%2C+Klaus%22">Wiedemann, Klaus</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kiefer%2C+Falk%22">Kiefer, Falk</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Aug2021, Vol. 271 Issue 5, p963-974. 12p. 2 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Obesity%22">Obesity</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-derived+neurotrophic+factor%22">Brain-derived neurotrophic factor</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Desire%22">Desire</searchLink>
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  Data: There is increasing evidence that brain-derived neurotrophic factor (BDNF) impacts on the development of obesity. We are the first to test the hypothesis that BDNF levels might be associated with neural reactivity to food cues in patients suffering from obesity and healthy controls. We assessed visual food cue-induced neural response in 19 obese patients and 20 matched controls using functional magnetic resonance imaging and analyzed the associations between BDNF levels, food cue-reactivity and food craving. Whole-brain analysis in both groups revealed that food cues elicited higher neural activation in clusters of mesolimbic brain areas including the insula (food > neutral). Patients suffering from obesity showed a significant positive correlation between plasma BDNF levels and visual food cue-reactivity in the bilateral insulae. In addition, patients suffering from obesity with positive food cue-induced insula activation also reported significantly higher food craving than those with low cue-reactivity—an effect that was absent in normal weight participants. The present findings implicate that BDNF levels in patients suffering from obesity might be involved in food craving and obesity in humans. This highlights the importance to consider BDNF pathways when investigating obesity and obesity treatment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Aug2021
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