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The association of telomere length with substance use disorders: a systematic review and meta‐analysis of observational studies.

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Title: The association of telomere length with substance use disorders: a systematic review and meta‐analysis of observational studies.
Authors: Navarro‐Mateu, Fernando (AUTHOR), Husky, Mathilde (AUTHOR), Cayuela‐Fuentes, Pedro (AUTHOR), Álvarez, Francisco‐Javier (AUTHOR), Roca‐Vega, Agustín (AUTHOR), Rubio‐Aparicio, María (AUTHOR), Chirlaque, María Dolores (AUTHOR), Cayuela, María Luisa (AUTHOR), Martínez, Salvador (AUTHOR), Sánchez‐Meca, Julio (AUTHOR)
Source: Addiction. Aug2021, Vol. 116 Issue 8, p1954-1972. 19p. 1 Diagram, 10 Charts, 2 Graphs.
Subjects: Complications of alcoholism, Telomeres, Statistics, Substance abuse, Meta-analysis, Confidence intervals, Systematic reviews, Cellular aging, Descriptive statistics, Data analysis, Disease complications
Abstract: Background and Aims: Several recent studies have investigated the relationship between telomere length and substance use disorders with inconsistent results. We aimed to assess this association and to identify moderators of the relationship. Methods: Systematic review and meta‐analysis. Selection criteria were observational studies reporting telomere length in people with a substance use disorder compared with a control group. Studies focused solely on nicotine addiction, employing other study designs, and non‐human studies were excluded. Study selection and data extraction were independently conducted by two researchers following a standardized protocol and included studies until December 2019. Standardized mean differences were used as the effect size index [d; 95% confidence interval (CI)] and random‐effects models were used for the meta‐analysis. Cochran's Q‐statistic, I2 index, visual inspection of the forest plot and a 95% prediction interval were applied to verify study heterogeneity. Subgroup analyses and meta‐regressions were conducted to explore heterogeneity. Small study effects were examined using the 'funnel plot', the Egger test, Duval & Tweedie's trim‐and‐fill method and the precision‐effect test–precision‐effect estimate with standard error (PET‐PEESE) method. The risk of bias and the quality of evidence were assessed. Results: Ten studies (12 analysis units with 2671 cases and 4532 controls) met the selection criteria. An overall effect size of moderate magnitude was found (d+ = −0.63; 95% CI = −1.00 and −0.26; P = 0.0008). A potential small study effect was detected, as well as large heterogeneity between studies (Q‐statistic P < 0.001, I2 = 97.3%). Selection of controls, reporting laboratory quality control procedures and total sample size significantly affected the effect size. The quality of the evidence was very low, based on risk of bias analysis and the grading of recommendations assessment, development and evaluation (GRADE) system. Conclusions: People with substance use disorders appear to have shorter telomere length than controls; however, this finding should be interpreted with caution due to the poor quality of the evidence. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The association of telomere length with substance use disorders: a systematic review and meta‐analysis of observational studies.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Navarro‐Mateu%2C+Fernando%22&quot;&gt;Navarro‐Mateu, Fernando&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Husky%2C+Mathilde%22&quot;&gt;Husky, Mathilde&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cayuela‐Fuentes%2C+Pedro%22&quot;&gt;Cayuela‐Fuentes, Pedro&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22&#193;lvarez%2C+Francisco‐Javier%22&quot;&gt;&#193;lvarez, Francisco‐Javier&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Roca‐Vega%2C+Agust&#237;n%22&quot;&gt;Roca‐Vega, Agust&#237;n&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rubio‐Aparicio%2C+Mar&#237;a%22&quot;&gt;Rubio‐Aparicio, Mar&#237;a&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chirlaque%2C+Mar&#237;a+Dolores%22&quot;&gt;Chirlaque, Mar&#237;a Dolores&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cayuela%2C+Mar&#237;a+Luisa%22&quot;&gt;Cayuela, Mar&#237;a Luisa&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mart&#237;nez%2C+Salvador%22&quot;&gt;Mart&#237;nez, Salvador&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22S&#225;nchez‐Meca%2C+Julio%22&quot;&gt;S&#225;nchez‐Meca, Julio&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Addiction%22&quot;&gt;Addiction&lt;/searchLink&gt;. Aug2021, Vol. 116 Issue 8, p1954-1972. 19p. 1 Diagram, 10 Charts, 2 Graphs.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background and Aims: Several recent studies have investigated the relationship between telomere length and substance use disorders with inconsistent results. We aimed to assess this association and to identify moderators of the relationship. Methods: Systematic review and meta‐analysis. Selection criteria were observational studies reporting telomere length in people with a substance use disorder compared with a control group. Studies focused solely on nicotine addiction, employing other study designs, and non‐human studies were excluded. Study selection and data extraction were independently conducted by two researchers following a standardized protocol and included studies until December 2019. Standardized mean differences were used as the effect size index [d; 95% confidence interval (CI)] and random‐effects models were used for the meta‐analysis. Cochran&#39;s Q‐statistic, I2 index, visual inspection of the forest plot and a 95% prediction interval were applied to verify study heterogeneity. Subgroup analyses and meta‐regressions were conducted to explore heterogeneity. Small study effects were examined using the &#39;funnel plot&#39;, the Egger test, Duval &amp; Tweedie&#39;s trim‐and‐fill method and the precision‐effect test–precision‐effect estimate with standard error (PET‐PEESE) method. The risk of bias and the quality of evidence were assessed. Results: Ten studies (12 analysis units with 2671 cases and 4532 controls) met the selection criteria. An overall effect size of moderate magnitude was found (d+ = −0.63; 95% CI = −1.00 and −0.26; P = 0.0008). A potential small study effect was detected, as well as large heterogeneity between studies (Q‐statistic P &lt; 0.001, I2 = 97.3%). Selection of controls, reporting laboratory quality control procedures and total sample size significantly affected the effect size. The quality of the evidence was very low, based on risk of bias analysis and the grading of recommendations assessment, development and evaluation (GRADE) system. Conclusions: People with substance use disorders appear to have shorter telomere length than controls; however, this finding should be interpreted with caution due to the poor quality of the evidence. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/add.15312
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 19
        StartPage: 1954
    Subjects:
      – SubjectFull: Complications of alcoholism
        Type: general
      – SubjectFull: Telomeres
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Substance abuse
        Type: general
      – SubjectFull: Meta-analysis
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Systematic reviews
        Type: general
      – SubjectFull: Cellular aging
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Disease complications
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      – TitleFull: The association of telomere length with substance use disorders: a systematic review and meta‐analysis of observational studies.
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            – D: 01
              M: 08
              Text: Aug2021
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              Y: 2021
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