View in EDS HTML Full Text PDF Full Text

An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.

Saved in:
Bibliographic Details
Title: An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
Authors: Poirier, Enzo Z., Buck, Michael D., Chakravarty, Probir, Carvalho, Joana, Frederico, Bruno, Cardoso, Ana, Healy, Lyn, Ulferts, Rachel, Beale, Rupert, e Sousa, Caetano Reis
Source: Science (pre-March 2025). 7/9/2021, Vol. 373 Issue 6551, p231-236. 6p. 4 Diagrams.
Subjects: Antiviral agents, Stem cells, Mammals, RNA viruses, Interferons, Viral replication, Cell differentiation
Abstract: In mammals, early resistance to viruses relies on interferons, which protect differentiated cells but not stem cells from viral replication. Many other organisms rely instead on RNA interference (RNAi) mediated by a specialized Dicer protein that cleaves viral double-stranded RNA. Whether RNAi also contributes to mammalian antiviral immunity remains controversial. We identified an isoform of Dicer, named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses—including Zika virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—by dicing viral double-stranded RNA to orchestrate antiviral RNAi. Our work sheds light on the molecular regulation of antiviral RNAi in mammalian innate immunity, in which different cell-intrinsic antiviral pathways can be tailored to the differentiation status of cells. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 151322177
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Poirier%2C+Enzo+Z%2E%22">Poirier, Enzo Z.</searchLink><br /><searchLink fieldCode="AR" term="%22Buck%2C+Michael+D%2E%22">Buck, Michael D.</searchLink><br /><searchLink fieldCode="AR" term="%22Chakravarty%2C+Probir%22">Chakravarty, Probir</searchLink><br /><searchLink fieldCode="AR" term="%22Carvalho%2C+Joana%22">Carvalho, Joana</searchLink><br /><searchLink fieldCode="AR" term="%22Frederico%2C+Bruno%22">Frederico, Bruno</searchLink><br /><searchLink fieldCode="AR" term="%22Cardoso%2C+Ana%22">Cardoso, Ana</searchLink><br /><searchLink fieldCode="AR" term="%22Healy%2C+Lyn%22">Healy, Lyn</searchLink><br /><searchLink fieldCode="AR" term="%22Ulferts%2C+Rachel%22">Ulferts, Rachel</searchLink><br /><searchLink fieldCode="AR" term="%22Beale%2C+Rupert%22">Beale, Rupert</searchLink><br /><searchLink fieldCode="AR" term="%22e+Sousa%2C+Caetano+Reis%22">e Sousa, Caetano Reis</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 7/9/2021, Vol. 373 Issue 6551, p231-236. 6p. 4 Diagrams.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Antiviral+agents%22">Antiviral agents</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Mammals%22">Mammals</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+viruses%22">RNA viruses</searchLink><br /><searchLink fieldCode="DE" term="%22Interferons%22">Interferons</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+replication%22">Viral replication</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+differentiation%22">Cell differentiation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In mammals, early resistance to viruses relies on interferons, which protect differentiated cells but not stem cells from viral replication. Many other organisms rely instead on RNA interference (RNAi) mediated by a specialized Dicer protein that cleaves viral double-stranded RNA. Whether RNAi also contributes to mammalian antiviral immunity remains controversial. We identified an isoform of Dicer, named antiviral Dicer (aviD), that protects tissue stem cells from RNA viruses—including Zika virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—by dicing viral double-stranded RNA to orchestrate antiviral RNAi. Our work sheds light on the molecular regulation of antiviral RNAi in mammalian innate immunity, in which different cell-intrinsic antiviral pathways can be tailored to the differentiation status of cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=151322177
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.abg2264
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 231
    Subjects:
      – SubjectFull: Antiviral agents
        Type: general
      – SubjectFull: Stem cells
        Type: general
      – SubjectFull: Mammals
        Type: general
      – SubjectFull: RNA viruses
        Type: general
      – SubjectFull: Interferons
        Type: general
      – SubjectFull: Viral replication
        Type: general
      – SubjectFull: Cell differentiation
        Type: general
    Titles:
      – TitleFull: An isoform of Dicer protects mammalian stem cells against multiple RNA viruses.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Poirier, Enzo Z.
      – PersonEntity:
          Name:
            NameFull: Buck, Michael D.
      – PersonEntity:
          Name:
            NameFull: Chakravarty, Probir
      – PersonEntity:
          Name:
            NameFull: Carvalho, Joana
      – PersonEntity:
          Name:
            NameFull: Frederico, Bruno
      – PersonEntity:
          Name:
            NameFull: Cardoso, Ana
      – PersonEntity:
          Name:
            NameFull: Healy, Lyn
      – PersonEntity:
          Name:
            NameFull: Ulferts, Rachel
      – PersonEntity:
          Name:
            NameFull: Beale, Rupert
      – PersonEntity:
          Name:
            NameFull: e Sousa, Caetano Reis
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 07
              Text: 7/9/2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 373
            – Type: issue
              Value: 6551
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1