View in EDS HTML Full Text PDF Full Text

Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior.

Saved in:
Bibliographic Details
Title: Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior.
Authors: Werhahn, Julia E., Mohl, Susanna, Willinger, David, Smigielski, Lukasz, Roth, Alexander, Hofstetter, Christoph, Stämpfli, Philipp, Naaijen, Jilly, Mulder, Leandra M., Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Kleine Deters, Renee, Aggensteiner, Pascal M., Holz, Nathalie E., Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C., Schulze, Ulrike M. E., Lythgoe, David J.
Source: European Child & Adolescent Psychiatry. Aug2021, Vol. 30 Issue 8, p1237-1249. 13p. 2 Diagrams, 1 Chart, 1 Graph.
Subjects: Research, Empathy, Functional connectivity, Medical cooperation, Cognition, Behavior disorders, Attention-deficit hyperactivity disorder, Comparative studies, Aggression (Psychology), Amygdaloid body, Emotions, Comorbidity, Morale, Symptoms
Geographic Terms: Europe
Abstract: There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02–18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala–precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 151566916
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Werhahn%2C+Julia+E%2E%22">Werhahn, Julia E.</searchLink><br /><searchLink fieldCode="AR" term="%22Mohl%2C+Susanna%22">Mohl, Susanna</searchLink><br /><searchLink fieldCode="AR" term="%22Willinger%2C+David%22">Willinger, David</searchLink><br /><searchLink fieldCode="AR" term="%22Smigielski%2C+Lukasz%22">Smigielski, Lukasz</searchLink><br /><searchLink fieldCode="AR" term="%22Roth%2C+Alexander%22">Roth, Alexander</searchLink><br /><searchLink fieldCode="AR" term="%22Hofstetter%2C+Christoph%22">Hofstetter, Christoph</searchLink><br /><searchLink fieldCode="AR" term="%22Stämpfli%2C+Philipp%22">Stämpfli, Philipp</searchLink><br /><searchLink fieldCode="AR" term="%22Naaijen%2C+Jilly%22">Naaijen, Jilly</searchLink><br /><searchLink fieldCode="AR" term="%22Mulder%2C+Leandra+M%2E%22">Mulder, Leandra M.</searchLink><br /><searchLink fieldCode="AR" term="%22Glennon%2C+Jeffrey+C%2E%22">Glennon, Jeffrey C.</searchLink><br /><searchLink fieldCode="AR" term="%22Hoekstra%2C+Pieter+J%2E%22">Hoekstra, Pieter J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dietrich%2C+Andrea%22">Dietrich, Andrea</searchLink><br /><searchLink fieldCode="AR" term="%22Kleine+Deters%2C+Renee%22">Kleine Deters, Renee</searchLink><br /><searchLink fieldCode="AR" term="%22Aggensteiner%2C+Pascal+M%2E%22">Aggensteiner, Pascal M.</searchLink><br /><searchLink fieldCode="AR" term="%22Holz%2C+Nathalie+E%2E%22">Holz, Nathalie E.</searchLink><br /><searchLink fieldCode="AR" term="%22Baumeister%2C+Sarah%22">Baumeister, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Banaschewski%2C+Tobias%22">Banaschewski, Tobias</searchLink><br /><searchLink fieldCode="AR" term="%22Saam%2C+Melanie+C%2E%22">Saam, Melanie C.</searchLink><br /><searchLink fieldCode="AR" term="%22Schulze%2C+Ulrike+M%2E+E%2E%22">Schulze, Ulrike M. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Lythgoe%2C+David+J%2E%22">Lythgoe, David J.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. Aug2021, Vol. 30 Issue 8, p1237-1249. 13p. 2 Diagrams, 1 Chart, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Empathy%22">Empathy</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+disorders%22">Behavior disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Aggression+%28Psychology%29%22">Aggression (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Emotions%22">Emotions</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Morale%22">Morale</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Europe%22">Europe</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: There is increasing evidence for altered brain resting state functional connectivity in adolescents with disruptive behavior. While a considerable body of behavioral research points to differences between reactive and proactive aggression, it remains unknown whether these two subtypes have dissociable effects on connectivity. Additionally, callous-unemotional traits are important specifiers in subtyping aggressive behavior along the affective dimension. Accordingly, we examined associations between two aggression subtypes along with callous-unemotional traits using a seed-to-voxel approach. Six functionally relevant seeds were selected to probe the salience and the default mode network, based on their presumed role in aggression. The resting state sequence was acquired from 207 children and adolescents of both sexes [mean age (standard deviation) = 13.30 (2.60); range = 8.02–18.35] as part of a Europe-based multi-center study. One hundred eighteen individuals exhibiting disruptive behavior (conduct disorder/oppositional defiant disorder) with varying comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms were studied, together with 89 healthy controls. Proactive aggression was associated with increased left amygdala–precuneus coupling, while reactive aggression related to hyper-connectivities of the posterior cingulate cortex (PCC) to the parahippocampus, the left amygdala to the precuneus and to hypo-connectivity between the right anterior insula and the nucleus caudate. Callous-unemotional traits were linked to distinct hyper-connectivities to frontal, parietal, and cingulate areas. Additionally, compared to controls, cases demonstrated reduced connectivity of the PCC and left anterior insula to left frontal areas, the latter only when controlling for ADHD scores. Taken together, this study revealed aggression-subtype-specific patterns involving areas associated with emotion, empathy, morality, and cognitive control. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=151566916
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00787-020-01601-9
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 1237
    Subjects:
      – SubjectFull: Research
        Type: general
      – SubjectFull: Empathy
        Type: general
      – SubjectFull: Functional connectivity
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Cognition
        Type: general
      – SubjectFull: Behavior disorders
        Type: general
      – SubjectFull: Attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Aggression (Psychology)
        Type: general
      – SubjectFull: Amygdaloid body
        Type: general
      – SubjectFull: Emotions
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Morale
        Type: general
      – SubjectFull: Symptoms
        Type: general
      – SubjectFull: Europe
        Type: general
    Titles:
      – TitleFull: Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Werhahn, Julia E.
      – PersonEntity:
          Name:
            NameFull: Mohl, Susanna
      – PersonEntity:
          Name:
            NameFull: Willinger, David
      – PersonEntity:
          Name:
            NameFull: Smigielski, Lukasz
      – PersonEntity:
          Name:
            NameFull: Roth, Alexander
      – PersonEntity:
          Name:
            NameFull: Hofstetter, Christoph
      – PersonEntity:
          Name:
            NameFull: Stämpfli, Philipp
      – PersonEntity:
          Name:
            NameFull: Naaijen, Jilly
      – PersonEntity:
          Name:
            NameFull: Mulder, Leandra M.
      – PersonEntity:
          Name:
            NameFull: Glennon, Jeffrey C.
      – PersonEntity:
          Name:
            NameFull: Hoekstra, Pieter J.
      – PersonEntity:
          Name:
            NameFull: Dietrich, Andrea
      – PersonEntity:
          Name:
            NameFull: Kleine Deters, Renee
      – PersonEntity:
          Name:
            NameFull: Aggensteiner, Pascal M.
      – PersonEntity:
          Name:
            NameFull: Holz, Nathalie E.
      – PersonEntity:
          Name:
            NameFull: Baumeister, Sarah
      – PersonEntity:
          Name:
            NameFull: Banaschewski, Tobias
      – PersonEntity:
          Name:
            NameFull: Saam, Melanie C.
      – PersonEntity:
          Name:
            NameFull: Schulze, Ulrike M. E.
      – PersonEntity:
          Name:
            NameFull: Lythgoe, David J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 10188827
          Numbering:
            – Type: volume
              Value: 30
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: European Child & Adolescent Psychiatry
              Type: main
ResultId 1