View in EDS

Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging.

Saved in:
Bibliographic Details
Title: Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging.
Authors: Krell‐Roesch, Janina (AUTHOR), Syrjanen, Jeremy A. (AUTHOR), Machulda, Mary M. (AUTHOR), Christianson, Teresa J. (AUTHOR), Kremers, Walter K. (AUTHOR), Mielke, Michelle M. (AUTHOR), Knopman, David S. (AUTHOR), Petersen, Ronald C. (AUTHOR), Vassilaki, Maria (AUTHOR), Geda, Yonas E. (AUTHOR)
Source: International Journal of Geriatric Psychiatry. Sep2021, Vol. 36 Issue 9, p1362-1369. 8p.
Subjects: Mayo Clinic, Older people, Apathy, Symptoms, Dementia, Mild cognitive impairment, Beck Anxiety Inventory
Abstract: Objective: Neuropsychiatric symptoms (NPS) are associated with the risk of incident mild cognitive impairment (MCI) and dementia. We examined associations between NPS and the outcomes of global and domain‐specific cognitive trajectories. Methods: In this longitudinal study conducted in the setting of the population‐based Mayo Clinic Study of Aging, 5081 community‐dwelling, nondemented individuals aged ≥50 years (51% males) underwent NPS assessment using Neuropsychiatric Inventory Questionnaire (NPI‐Q), and Beck Depression and Anxiety Inventories (BDI‐II, BAI). Global and domain‐specific (memory, language, attention, and visuospatial skills) cognitive performance was assessed through neuropsychological testing every 15 months. Associations between baseline NPS and trajectories for individual yearly change in cognitive z‐scores were calculated using linear mixed‐effect models. Results: Cognition declined regardless of NPS status over the median follow‐up of 4.5 years. Presence of NPS was associated with increased cognitive decline. Differences in annualized change in global cognition z‐scores for participants with NPS compared to without NPS ranged from −0.018 (95% CI −0.032, −0.004; p = 0.011) for irritability to −0.159 (−0.254, −0.065; p = 0.001) for hallucinations. Associations between NPS and annual decline in global cognition were significant for most NPI‐Q‐assessed NPS and clinical depression (BDI‐II≥13). Participants with NPI‐Q‐assessed depression, apathy, nighttime behavior, and clinical depression had greater decline in all domain‐specific z‐scores; presence of delusions and anxiety was associated with more pronounced decline in language, attention and visuospatial skills. Conclusion: NPS were associated with a more accelerated cognitive decline. Clinical assessment and potential treatment of NPS is warranted even in a community setting as NPS may impact cognitive decline in nondemented individuals. Key points: Presence of neuropsychiatric symptoms was associated with a more accelerated global and domain‐specific cognitive declineParticipants with depression or apathy had greater decline in all domain‐specific z‐scoresPresence of delusions and anxiety was associated with more pronounced decline in language, attention and visuospatial skillsClinical assessment and potential treatment of neuropsychiatric symptoms is warranted even in a community setting [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 151739932
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Krell‐Roesch%2C+Janina%22">Krell‐Roesch, Janina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Syrjanen%2C+Jeremy+A%2E%22">Syrjanen, Jeremy A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Machulda%2C+Mary+M%2E%22">Machulda, Mary M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Christianson%2C+Teresa+J%2E%22">Christianson, Teresa J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kremers%2C+Walter+K%2E%22">Kremers, Walter K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mielke%2C+Michelle+M%2E%22">Mielke, Michelle M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Knopman%2C+David+S%2E%22">Knopman, David S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Petersen%2C+Ronald+C%2E%22">Petersen, Ronald C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vassilaki%2C+Maria%22">Vassilaki, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Geda%2C+Yonas+E%2E%22">Geda, Yonas E.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. Sep2021, Vol. 36 Issue 9, p1362-1369. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Mayo+Clinic%22">Mayo Clinic</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Apathy%22">Apathy</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Dementia%22">Dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Mild+cognitive+impairment%22">Mild cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Beck+Anxiety+Inventory%22">Beck Anxiety Inventory</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Neuropsychiatric symptoms (NPS) are associated with the risk of incident mild cognitive impairment (MCI) and dementia. We examined associations between NPS and the outcomes of global and domain‐specific cognitive trajectories. Methods: In this longitudinal study conducted in the setting of the population‐based Mayo Clinic Study of Aging, 5081 community‐dwelling, nondemented individuals aged ≥50 years (51% males) underwent NPS assessment using Neuropsychiatric Inventory Questionnaire (NPI‐Q), and Beck Depression and Anxiety Inventories (BDI‐II, BAI). Global and domain‐specific (memory, language, attention, and visuospatial skills) cognitive performance was assessed through neuropsychological testing every 15 months. Associations between baseline NPS and trajectories for individual yearly change in cognitive z‐scores were calculated using linear mixed‐effect models. Results: Cognition declined regardless of NPS status over the median follow‐up of 4.5 years. Presence of NPS was associated with increased cognitive decline. Differences in annualized change in global cognition z‐scores for participants with NPS compared to without NPS ranged from −0.018 (95% CI −0.032, −0.004; p = 0.011) for irritability to −0.159 (−0.254, −0.065; p = 0.001) for hallucinations. Associations between NPS and annual decline in global cognition were significant for most NPI‐Q‐assessed NPS and clinical depression (BDI‐II≥13). Participants with NPI‐Q‐assessed depression, apathy, nighttime behavior, and clinical depression had greater decline in all domain‐specific z‐scores; presence of delusions and anxiety was associated with more pronounced decline in language, attention and visuospatial skills. Conclusion: NPS were associated with a more accelerated cognitive decline. Clinical assessment and potential treatment of NPS is warranted even in a community setting as NPS may impact cognitive decline in nondemented individuals. Key points: Presence of neuropsychiatric symptoms was associated with a more accelerated global and domain‐specific cognitive declineParticipants with depression or apathy had greater decline in all domain‐specific z‐scoresPresence of delusions and anxiety was associated with more pronounced decline in language, attention and visuospatial skillsClinical assessment and potential treatment of neuropsychiatric symptoms is warranted even in a community setting [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=151739932
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/gps.5528
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1362
    Subjects:
      – SubjectFull: Mayo Clinic
        Type: general
      – SubjectFull: Older people
        Type: general
      – SubjectFull: Apathy
        Type: general
      – SubjectFull: Symptoms
        Type: general
      – SubjectFull: Dementia
        Type: general
      – SubjectFull: Mild cognitive impairment
        Type: general
      – SubjectFull: Beck Anxiety Inventory
        Type: general
    Titles:
      – TitleFull: Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Krell‐Roesch, Janina
      – PersonEntity:
          Name:
            NameFull: Syrjanen, Jeremy A.
      – PersonEntity:
          Name:
            NameFull: Machulda, Mary M.
      – PersonEntity:
          Name:
            NameFull: Christianson, Teresa J.
      – PersonEntity:
          Name:
            NameFull: Kremers, Walter K.
      – PersonEntity:
          Name:
            NameFull: Mielke, Michelle M.
      – PersonEntity:
          Name:
            NameFull: Knopman, David S.
      – PersonEntity:
          Name:
            NameFull: Petersen, Ronald C.
      – PersonEntity:
          Name:
            NameFull: Vassilaki, Maria
      – PersonEntity:
          Name:
            NameFull: Geda, Yonas E.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 08856230
          Numbering:
            – Type: volume
              Value: 36
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: International Journal of Geriatric Psychiatry
              Type: main
ResultId 1