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Long-term effects of bronchopulmonary dysplasia on lung function: a pilot study in preschool children's cohort.

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Title: Long-term effects of bronchopulmonary dysplasia on lung function: a pilot study in preschool children's cohort.
Authors: Manti, S. (AUTHOR), Galdo, F. (AUTHOR), Parisi, G. F. (AUTHOR), Napolitano, M. (AUTHOR), Decimo, F. (AUTHOR), Leonardi, S. (AUTHOR), Miraglia Del Giudice, M. (AUTHOR)
Source: Journal of Asthma. Sep2021, Vol. 58 Issue 9, p1186-1193. 8p.
Subjects: European Community, Bronchiolitis, Preschool children, Bronchopulmonary dysplasia, Small for gestational age, Atopy, Artificial respiration, Premature infants
Abstract: Although the long term negative effects of bronchopulmonary dysplasia (BPD) are well known, follow-up studies of preterm infants with BPD into childhood are lacking. Forty-two preschool children (age range 3–6 years) who were born before 32 weeks of gestational age and affected by BPD were enrolled. Pre-, peri-, and post-natal data were collected. During the follow up appointment complete physical examination and lung function (impulse oscillometry (IOS)) were recorded. The European Community Respiratory Health Survey (ECRHS) questionnaire was administered to all enrolled subjects. Thirty patients were included in the final analysis. The BPD group did not differ in comparison to the non-BPD group in terms of lung function (p > 0.05). By comparing all subjects enrolled, We detected extremely low-birth-weight (ELBW) infants with height-, weight-, and gender-related reference values and a significant trend of increasing resistance values (R5Hz, R5-20 Hz) and respiratory impedance (Z5Hz) (p < 0.05). No significant difference in bronchial reversibility test was observed among BPD non-BPD groups (p < 0.05). The frequency of gastroesophageal reflux disease was significantly higher in patients with BPD when compared to non-BPD group (p < 0.05). Significant differences in gestational age, oxygen supplementation (days), mechanical ventilation therapy (days), and sepsis between BPD and non-BPD groups were also observed (p < 0.05). There were no significant differences in the prevalence of family and personal history of atopy and/or allergic diseases, tobacco exposure, respiratory symptoms, respiratory syncytial virus bronchiolitis, exercise induced dyspnea, treatment with ß-2 bronchodilators and inhaled corticosteroids among the groups (p > 0.05). The respiratory function in preschool children born with ELBW is characterized by an increase in impedance and resistance of small airways. No statistically significant differences were found between ELBW children with BPD and without BPD. With regards to the smallest gestational age, the longer duration of O2 therapy during hospitalization, and sepsis significantly resulted in a worse respiratory function. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Long-term effects of bronchopulmonary dysplasia on lung function: a pilot study in preschool children&#39;s cohort.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Manti%2C+S%2E%22&quot;&gt;Manti, S.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Galdo%2C+F%2E%22&quot;&gt;Galdo, F.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Parisi%2C+G%2E+F%2E%22&quot;&gt;Parisi, G. F.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Napolitano%2C+M%2E%22&quot;&gt;Napolitano, M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Decimo%2C+F%2E%22&quot;&gt;Decimo, F.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Leonardi%2C+S%2E%22&quot;&gt;Leonardi, S.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Miraglia+Del+Giudice%2C+M%2E%22&quot;&gt;Miraglia Del Giudice, M.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Asthma%22&quot;&gt;Journal of Asthma&lt;/searchLink&gt;. Sep2021, Vol. 58 Issue 9, p1186-1193. 8p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22European+Community%22&quot;&gt;European Community&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bronchiolitis%22&quot;&gt;Bronchiolitis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Preschool+children%22&quot;&gt;Preschool children&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bronchopulmonary+dysplasia%22&quot;&gt;Bronchopulmonary dysplasia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Small+for+gestational+age%22&quot;&gt;Small for gestational age&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Atopy%22&quot;&gt;Atopy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Artificial+respiration%22&quot;&gt;Artificial respiration&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Premature+infants%22&quot;&gt;Premature infants&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Although the long term negative effects of bronchopulmonary dysplasia (BPD) are well known, follow-up studies of preterm infants with BPD into childhood are lacking. Forty-two preschool children (age range 3–6 years) who were born before 32 weeks of gestational age and affected by BPD were enrolled. Pre-, peri-, and post-natal data were collected. During the follow up appointment complete physical examination and lung function (impulse oscillometry (IOS)) were recorded. The European Community Respiratory Health Survey (ECRHS) questionnaire was administered to all enrolled subjects. Thirty patients were included in the final analysis. The BPD group did not differ in comparison to the non-BPD group in terms of lung function (p &gt; 0.05). By comparing all subjects enrolled, We detected extremely low-birth-weight (ELBW) infants with height-, weight-, and gender-related reference values and a significant trend of increasing resistance values (R5Hz, R5-20 Hz) and respiratory impedance (Z5Hz) (p &lt; 0.05). No significant difference in bronchial reversibility test was observed among BPD non-BPD groups (p &lt; 0.05). The frequency of gastroesophageal reflux disease was significantly higher in patients with BPD when compared to non-BPD group (p &lt; 0.05). Significant differences in gestational age, oxygen supplementation (days), mechanical ventilation therapy (days), and sepsis between BPD and non-BPD groups were also observed (p &lt; 0.05). There were no significant differences in the prevalence of family and personal history of atopy and/or allergic diseases, tobacco exposure, respiratory symptoms, respiratory syncytial virus bronchiolitis, exercise induced dyspnea, treatment with &#223;-2 bronchodilators and inhaled corticosteroids among the groups (p &gt; 0.05). The respiratory function in preschool children born with ELBW is characterized by an increase in impedance and resistance of small airways. No statistically significant differences were found between ELBW children with BPD and without BPD. With regards to the smallest gestational age, the longer duration of O2 therapy during hospitalization, and sepsis significantly resulted in a worse respiratory function. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of Asthma is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/02770903.2020.1779289
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 1186
    Subjects:
      – SubjectFull: European Community
        Type: general
      – SubjectFull: Bronchiolitis
        Type: general
      – SubjectFull: Preschool children
        Type: general
      – SubjectFull: Bronchopulmonary dysplasia
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      – SubjectFull: Small for gestational age
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      – SubjectFull: Atopy
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      – SubjectFull: Artificial respiration
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      – SubjectFull: Premature infants
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      – TitleFull: Long-term effects of bronchopulmonary dysplasia on lung function: a pilot study in preschool children's cohort.
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              Text: Sep2021
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              Y: 2021
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