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No evidence of the clinical utility of single-item breakpoint to inform on tobacco demand in persons with substance use disorders.

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Title: No evidence of the clinical utility of single-item breakpoint to inform on tobacco demand in persons with substance use disorders.
Authors: González-Roz, Alba (AUTHOR), Secades-Villa, Roberto (AUTHOR), Aonso-Diego, Gema (AUTHOR), Weidberg, Sara (AUTHOR), Fernández-Hermida, José R. (AUTHOR)
Source: Psychopharmacology. Sep2021, Vol. 238 Issue 9, p2525-2533. 9p. 4 Charts.
Subjects: Substance abuse, Tobacco, Nicotine addiction, Behavioral economics, Nicotine, Prothrombin
Abstract: Rationale: Behavioral economics has shown that single-item demand indicators are promising for capturing crucial aspects of nicotine reinforcement. It is suggested that brief breakpoint measures perform comparably to full-length demand indices in characterizing nicotine dependence; however, there have been no thorough assessments of their validity in clinical settings. Objectives: This study aimed to assess the validity and accuracy of a single-item breakpoint in informing on tobacco demand. Methods: The sample consisted of 88 treatment-seeking smokers (% males = 70.5%) enrolled in substance use treatment. Participants provided data on smoking characteristics and completed the Fagerström Test for Nicotine Dependence, a single-item breakpoint measure and a 14-item cigarette purchase task (CPT). Hierarchical regressions were performed to compare the predictive capability of a single-item breakpoint and full-length tobacco demand indicators in determining nicotine addiction severity. Results: The single-item breakpoint was significantly correlated with all indices stemmed from the CPT and both latent factors (all r values =.250–.368). Neither the brief breakpoint nor the full-length breakpoint significantly predicted nicotine dependence. After controlling for sex and smoking variables, factor 2 [β =.565, p <.001] and its observed variables Omax [β =.279, p =.006], 1/elasticity [β =.340, p =.001], and intensity [β =.551, p <.001], robustly predicted nicotine dependence severity. Conclusions: Our findings do not support the validity of single-item breakpoint measures for characterizing nicotine dependence in substance users. In a bid to foster translational research, brief demand measures capturing Omax, intensity, and elasticity should be developed. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: No evidence of the clinical utility of single-item breakpoint to inform on tobacco demand in persons with substance use disorders.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Psychopharmacology%22&quot;&gt;Psychopharmacology&lt;/searchLink&gt;. Sep2021, Vol. 238 Issue 9, p2525-2533. 9p. 4 Charts.
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  Data: Rationale: Behavioral economics has shown that single-item demand indicators are promising for capturing crucial aspects of nicotine reinforcement. It is suggested that brief breakpoint measures perform comparably to full-length demand indices in characterizing nicotine dependence; however, there have been no thorough assessments of their validity in clinical settings. Objectives: This study aimed to assess the validity and accuracy of a single-item breakpoint in informing on tobacco demand. Methods: The sample consisted of 88 treatment-seeking smokers (% males = 70.5%) enrolled in substance use treatment. Participants provided data on smoking characteristics and completed the Fagerstr&#246;m Test for Nicotine Dependence, a single-item breakpoint measure and a 14-item cigarette purchase task (CPT). Hierarchical regressions were performed to compare the predictive capability of a single-item breakpoint and full-length tobacco demand indicators in determining nicotine addiction severity. Results: The single-item breakpoint was significantly correlated with all indices stemmed from the CPT and both latent factors (all r values =.250–.368). Neither the brief breakpoint nor the full-length breakpoint significantly predicted nicotine dependence. After controlling for sex and smoking variables, factor 2 [β =.565, p &lt;.001] and its observed variables Omax [β =.279, p =.006], 1/elasticity [β =.340, p =.001], and intensity [β =.551, p &lt;.001], robustly predicted nicotine dependence severity. Conclusions: Our findings do not support the validity of single-item breakpoint measures for characterizing nicotine dependence in substance users. In a bid to foster translational research, brief demand measures capturing Omax, intensity, and elasticity should be developed. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Text: English
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              Text: Sep2021
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