View in EDS HTML Full Text PDF Full Text

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes.

Saved in:
Bibliographic Details
Title: Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes.
Authors: Li, Ting, van Rooij, Daan, Roth Mota, Nina, Buitelaar, Jan K., Hoogman, Martine, Arias Vasquez, Alejandro, Franke, Barbara, Ambrosino, Sara, Banaschewski, Tobias, Bandeira, Cibele E., Bau, Claiton H.D., Baumeister, Sarah, Baur‐Streubel, Ramona, Bellgrove, Mark A., Biederman, Joseph, Bralten, Janita, Bramati, Ivanei E., Brandeis, Daniel, Berm, Silvia, Busatto, Geraldo F.
Source: Journal of Child Psychology & Psychiatry. Sep2021, Vol. 62 Issue 9, p1140-1149. 10p. 1 Diagram, 4 Charts, 1 Graph.
Subjects: Brain physiology, Research, Genetics, Analysis of variance, Confidence intervals, Magnetic resonance imaging, Attention-deficit hyperactivity disorder, Severity of illness index, T-test (Statistics), Factor analysis, Descriptive statistics, Chi-squared test, Data analysis software, Neuroradiology
Abstract: Background: Attention‐deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods: Using the large ENIGMA‐ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. Results: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case–control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. Conclusions: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case–control differences appear more pronounced at least in some of the subgroups. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 152164450
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Li%2C+Ting%22">Li, Ting</searchLink><br /><searchLink fieldCode="AR" term="%22van+Rooij%2C+Daan%22">van Rooij, Daan</searchLink><br /><searchLink fieldCode="AR" term="%22Roth+Mota%2C+Nina%22">Roth Mota, Nina</searchLink><br /><searchLink fieldCode="AR" term="%22Buitelaar%2C+Jan+K%2E%22">Buitelaar, Jan K.</searchLink><br /><searchLink fieldCode="AR" term="%22Hoogman%2C+Martine%22">Hoogman, Martine</searchLink><br /><searchLink fieldCode="AR" term="%22Arias+Vasquez%2C+Alejandro%22">Arias Vasquez, Alejandro</searchLink><br /><searchLink fieldCode="AR" term="%22Franke%2C+Barbara%22">Franke, Barbara</searchLink><br /><searchLink fieldCode="AR" term="%22Ambrosino%2C+Sara%22">Ambrosino, Sara</searchLink><br /><searchLink fieldCode="AR" term="%22Banaschewski%2C+Tobias%22">Banaschewski, Tobias</searchLink><br /><searchLink fieldCode="AR" term="%22Bandeira%2C+Cibele+E%2E%22">Bandeira, Cibele E.</searchLink><br /><searchLink fieldCode="AR" term="%22Bau%2C+Claiton+H%2ED%2E%22">Bau, Claiton H.D.</searchLink><br /><searchLink fieldCode="AR" term="%22Baumeister%2C+Sarah%22">Baumeister, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Baur‐Streubel%2C+Ramona%22">Baur‐Streubel, Ramona</searchLink><br /><searchLink fieldCode="AR" term="%22Bellgrove%2C+Mark+A%2E%22">Bellgrove, Mark A.</searchLink><br /><searchLink fieldCode="AR" term="%22Biederman%2C+Joseph%22">Biederman, Joseph</searchLink><br /><searchLink fieldCode="AR" term="%22Bralten%2C+Janita%22">Bralten, Janita</searchLink><br /><searchLink fieldCode="AR" term="%22Bramati%2C+Ivanei+E%2E%22">Bramati, Ivanei E.</searchLink><br /><searchLink fieldCode="AR" term="%22Brandeis%2C+Daniel%22">Brandeis, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Berm%2C+Silvia%22">Berm, Silvia</searchLink><br /><searchLink fieldCode="AR" term="%22Busatto%2C+Geraldo+F%2E%22">Busatto, Geraldo F.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Psychology+%26+Psychiatry%22">Journal of Child Psychology & Psychiatry</searchLink>. Sep2021, Vol. 62 Issue 9, p1140-1149. 10p. 1 Diagram, 4 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Brain+physiology%22">Brain physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Factor+analysis%22">Factor analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroradiology%22">Neuroradiology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Attention‐deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. Methods: Using the large ENIGMA‐ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. Results: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case–control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. Conclusions: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case–control differences appear more pronounced at least in some of the subgroups. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=152164450
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jcpp.13384
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 10
        StartPage: 1140
    Subjects:
      – SubjectFull: Brain physiology
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Factor analysis
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Chi-squared test
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Neuroradiology
        Type: general
    Titles:
      – TitleFull: Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Li, Ting
      – PersonEntity:
          Name:
            NameFull: van Rooij, Daan
      – PersonEntity:
          Name:
            NameFull: Roth Mota, Nina
      – PersonEntity:
          Name:
            NameFull: Buitelaar, Jan K.
      – PersonEntity:
          Name:
            NameFull: Hoogman, Martine
      – PersonEntity:
          Name:
            NameFull: Arias Vasquez, Alejandro
      – PersonEntity:
          Name:
            NameFull: Franke, Barbara
      – PersonEntity:
          Name:
            NameFull: Ambrosino, Sara
      – PersonEntity:
          Name:
            NameFull: Banaschewski, Tobias
      – PersonEntity:
          Name:
            NameFull: Bandeira, Cibele E.
      – PersonEntity:
          Name:
            NameFull: Bau, Claiton H.D.
      – PersonEntity:
          Name:
            NameFull: Baumeister, Sarah
      – PersonEntity:
          Name:
            NameFull: Baur‐Streubel, Ramona
      – PersonEntity:
          Name:
            NameFull: Bellgrove, Mark A.
      – PersonEntity:
          Name:
            NameFull: Biederman, Joseph
      – PersonEntity:
          Name:
            NameFull: Bralten, Janita
      – PersonEntity:
          Name:
            NameFull: Bramati, Ivanei E.
      – PersonEntity:
          Name:
            NameFull: Brandeis, Daniel
      – PersonEntity:
          Name:
            NameFull: Berm, Silvia
      – PersonEntity:
          Name:
            NameFull: Busatto, Geraldo F.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: Sep2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 00219630
          Numbering:
            – Type: volume
              Value: 62
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Journal of Child Psychology & Psychiatry
              Type: main
ResultId 1