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Maternal Vaccination and Infant Influenza and Pertussis.

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Title: Maternal Vaccination and Infant Influenza and Pertussis.
Authors: Rowe, Stacey L., Leder, Karin, Perrett, Kirsten P., Romero, Nicole, Nolan, Terry M., Stephens, Nicola, Cowie, Benjamin C., Cheng, Allen C.
Source: Pediatrics. Sep2021, Vol. 148 Issue 3, p1-14. 18p.
Subjects: Influenza prevention, Influenza vaccines, Immunization, Confidence intervals, Pregnant women, Whooping cough, Descriptive statistics, Hospital care, Influenza, Whooping cough vaccines, Odds ratio, Longitudinal method, Poisson distribution, Disease risk factors, Children
Geographic Terms: Victoria
Abstract: BACKGROUND AND OBJECTIVES: Infant influenza and pertussis disease causes considerable morbidity and mortality worldwide. We examined the effectiveness of maternal influenza and pertussis vaccines in preventing these diseases in infants. METHODS: This inception cohort study comprised women whose pregnancies ended between September 1, 2015, and December 31, 2017, in Victoria, Australia. Maternal vaccination status was sourced from the Victorian Perinatal Data Collection and linked to 5 data sets to ascertain infant outcomes and vaccination. The primary outcome of interest was laboratory-confirmed influenza or pertussis disease in infants aged <2 months, 2 to <6 months, and <6 months combined. Secondary outcomes included infant hospitalization (emergency presentation or admission) and death. Risk ratios and 95% confidence intervals (CIs) were estimated by Poisson regression. Vaccine effectiveness (VE) was estimated as (1 minus the risk ratio) x 100%. RESULTS: Among 186 962 pregnant women, 85 830 (45.9%) and 128 060 (68.5%) were vaccinated against influenza and pertussis, respectively. There were 175 and 51 infants with laboratory-confirmed influenza and pertussis disease, respectively. Influenza VE was 56.1% (95% CI, 23.3% to 74.9%) for infants aged <2 months and 35.7% (2.2% to 57.7%) for infants aged 2 to <6 months. Pertussis VE was 80.1% (95% CI, 37.1% to 93.7%) for infants aged <2 months and 31.8% (95% CI, -39.1% to 66.6%) for infants aged 2 to <6 months. CONCLUSIONS: Our study provides evidence of the direct effectiveness of maternal influenza and pertussis vaccination in preventing these diseases in infants aged <2 months. The findings strengthen the importance of maternal vaccination to prevent these diseases in infants. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Maternal Vaccination and Infant Influenza and Pertussis.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rowe%2C+Stacey+L%2E%22&quot;&gt;Rowe, Stacey L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Leder%2C+Karin%22&quot;&gt;Leder, Karin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Perrett%2C+Kirsten+P%2E%22&quot;&gt;Perrett, Kirsten P.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Romero%2C+Nicole%22&quot;&gt;Romero, Nicole&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nolan%2C+Terry+M%2E%22&quot;&gt;Nolan, Terry M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stephens%2C+Nicola%22&quot;&gt;Stephens, Nicola&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cowie%2C+Benjamin+C%2E%22&quot;&gt;Cowie, Benjamin C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cheng%2C+Allen+C%2E%22&quot;&gt;Cheng, Allen C.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Pediatrics%22&quot;&gt;Pediatrics&lt;/searchLink&gt;. Sep2021, Vol. 148 Issue 3, p1-14. 18p.
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– Name: Abstract
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  Data: BACKGROUND AND OBJECTIVES: Infant influenza and pertussis disease causes considerable morbidity and mortality worldwide. We examined the effectiveness of maternal influenza and pertussis vaccines in preventing these diseases in infants. METHODS: This inception cohort study comprised women whose pregnancies ended between September 1, 2015, and December 31, 2017, in Victoria, Australia. Maternal vaccination status was sourced from the Victorian Perinatal Data Collection and linked to 5 data sets to ascertain infant outcomes and vaccination. The primary outcome of interest was laboratory-confirmed influenza or pertussis disease in infants aged &lt;2 months, 2 to &lt;6 months, and &lt;6 months combined. Secondary outcomes included infant hospitalization (emergency presentation or admission) and death. Risk ratios and 95% confidence intervals (CIs) were estimated by Poisson regression. Vaccine effectiveness (VE) was estimated as (1 minus the risk ratio) x 100%. RESULTS: Among 186 962 pregnant women, 85 830 (45.9%) and 128 060 (68.5%) were vaccinated against influenza and pertussis, respectively. There were 175 and 51 infants with laboratory-confirmed influenza and pertussis disease, respectively. Influenza VE was 56.1% (95% CI, 23.3% to 74.9%) for infants aged &lt;2 months and 35.7% (2.2% to 57.7%) for infants aged 2 to &lt;6 months. Pertussis VE was 80.1% (95% CI, 37.1% to 93.7%) for infants aged &lt;2 months and 31.8% (95% CI, -39.1% to 66.6%) for infants aged 2 to &lt;6 months. CONCLUSIONS: Our study provides evidence of the direct effectiveness of maternal influenza and pertussis vaccination in preventing these diseases in infants aged &lt;2 months. The findings strengthen the importance of maternal vaccination to prevent these diseases in infants. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.2021-051076
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 1
    Subjects:
      – SubjectFull: Influenza prevention
        Type: general
      – SubjectFull: Influenza vaccines
        Type: general
      – SubjectFull: Immunization
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Pregnant women
        Type: general
      – SubjectFull: Whooping cough
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Hospital care
        Type: general
      – SubjectFull: Influenza
        Type: general
      – SubjectFull: Whooping cough vaccines
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Poisson distribution
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Victoria
        Type: general
    Titles:
      – TitleFull: Maternal Vaccination and Infant Influenza and Pertussis.
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            NameFull: Rowe, Stacey L.
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            NameFull: Leder, Karin
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            NameFull: Romero, Nicole
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            NameFull: Nolan, Terry M.
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            – D: 01
              M: 09
              Text: Sep2021
              Type: published
              Y: 2021
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              Value: 148
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            – TitleFull: Pediatrics
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