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Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal–amygdala 5-HT2A receptor density.

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Title: Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal–amygdala 5-HT2A receptor density.
Authors: Baeken, Chris (AUTHOR), Xu, Yanfeng (AUTHOR), Wu, Guo-Rong (AUTHOR), Dockx, Robrecht (AUTHOR), Peremans, Kathelijne (AUTHOR), De Raedt, Rudi (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Oct2021, Vol. 271 Issue 7, p1369-1378. 10p. 1 Diagram, 2 Charts, 1 Graph.
Subjects: Generalized anxiety disorder, Mental depression, Comorbidity, Symptom Checklist-90-Revised, Hostility, Serotonin receptors, Hippocampus (Brain), Amygdaloid body
Abstract: Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are severe and difficult-to-treat psychiatric illnesses with high rates of comorbidity. Although both disorders are treated with serotonergic based psychotropic agents, little is known on the influence of the serotonergic neurotransmitter system on the occurrence of comorbid GAD when clinically depressed. To investigate this poorly understood clinical question, we examined the involvement of frontolimbic post-synaptic 5-HT2A receptors in 20 medication-resistant depressed (MRD) patients with half of them diagnosed with comorbid GAD with 123I-5-I-R91150 SPECT. To explore whether 5-HT2A receptor-binding indices (BI) associated with comorbid GAD could be related to distinct psychopathological symptoms, all were assessed with the symptom Checklist-90-Revised (SCL-90-R). MRD patients with comorbid GAD displayed significantly higher 5-HT2A receptor BI in the hippocampal–amygdala complex, compared to MRD patients without GAD. Correlation analyses revealed that the 5-HT2A receptor BI in these areas were significantly related to the SCL-90-R subscale hostility (HOS), especially for those MRD patients with comorbid GAD. Comorbid MRD-GAD may be characterized with increased hippocampal–amygdala 5-HT2A receptor BI which could represent enhanced levels in hostility in such kinds of patients. Adapted psychotherapeutic interventions may be warranted. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal–amygdala 5-HT<subscript>2A</subscript> receptor density.
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  Data: <searchLink fieldCode="AR" term="%22Baeken%2C+Chris%22">Baeken, Chris</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Yanfeng%22">Xu, Yanfeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Guo-Rong%22">Wu, Guo-Rong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dockx%2C+Robrecht%22">Dockx, Robrecht</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peremans%2C+Kathelijne%22">Peremans, Kathelijne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Raedt%2C+Rudi%22">De Raedt, Rudi</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2021, Vol. 271 Issue 7, p1369-1378. 10p. 1 Diagram, 2 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Generalized+anxiety+disorder%22">Generalized anxiety disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Symptom+Checklist-90-Revised%22">Symptom Checklist-90-Revised</searchLink><br /><searchLink fieldCode="DE" term="%22Hostility%22">Hostility</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+receptors%22">Serotonin receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Major depressive disorder (MDD) and generalized anxiety disorder (GAD) are severe and difficult-to-treat psychiatric illnesses with high rates of comorbidity. Although both disorders are treated with serotonergic based psychotropic agents, little is known on the influence of the serotonergic neurotransmitter system on the occurrence of comorbid GAD when clinically depressed. To investigate this poorly understood clinical question, we examined the involvement of frontolimbic post-synaptic 5-HT2A receptors in 20 medication-resistant depressed (MRD) patients with half of them diagnosed with comorbid GAD with 123I-5-I-R91150 SPECT. To explore whether 5-HT2A receptor-binding indices (BI) associated with comorbid GAD could be related to distinct psychopathological symptoms, all were assessed with the symptom Checklist-90-Revised (SCL-90-R). MRD patients with comorbid GAD displayed significantly higher 5-HT2A receptor BI in the hippocampal–amygdala complex, compared to MRD patients without GAD. Correlation analyses revealed that the 5-HT2A receptor BI in these areas were significantly related to the SCL-90-R subscale hostility (HOS), especially for those MRD patients with comorbid GAD. Comorbid MRD-GAD may be characterized with increased hippocampal–amygdala 5-HT2A receptor BI which could represent enhanced levels in hostility in such kinds of patients. Adapted psychotherapeutic interventions may be warranted. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00406-021-01243-1
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        Text: English
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      – SubjectFull: Generalized anxiety disorder
        Type: general
      – SubjectFull: Mental depression
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      – SubjectFull: Comorbidity
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      – SubjectFull: Symptom Checklist-90-Revised
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      – SubjectFull: Hippocampus (Brain)
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      – SubjectFull: Amygdaloid body
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      – TitleFull: Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal–amygdala 5-HT2A receptor density.
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              Text: Oct2021
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