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PBMC telomerase activity in depression and the response to electroconvulsive therapy.

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Title: PBMC telomerase activity in depression and the response to electroconvulsive therapy.
Authors: Ryan, Karen M. (AUTHOR), Finnegan, Martha (AUTHOR), Harkin, Andrew (AUTHOR), McLoughlin, Declan M. (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Oct2021, Vol. 271 Issue 7, p1297-1307. 11p. 1 Chart, 3 Graphs.
Subjects: Electroconvulsive therapy, Mononuclear leukocytes, Telomerase, Hamilton Depression Inventory, DNA polymerases, Ketamine abuse
Abstract: Telomerase, the DNA polymerase responsible for maintaining telomere length, has previously been implicated in depression and the response to antidepressant drugs. In this study, we aimed to compare telomerase activity in peripheral blood mononuclear cells between patients with severe depression recruited as part of the KEEP-WELL Trial (Ketamine for Depression Relapse Prevention Following ECT; NCT02414932) and age- and sex-matched healthy volunteers both at baseline/pre-ECT and at follow-up 1 month later for controls or in patients after a course of ECT. We found no differences in telomerase activity between patients with depression (n = 20) compared to healthy controls (n = 33) at baseline/pre-ECT, or between patients treated with ECT compared to controls at follow-up. In patients, telomerase activity was not associated with mood, as assessed by the 24-item Hamilton Rating Scale for Depression, or the duration of the current depressive episode. Additionally, we found no significant relationship between telomerase activity and exposure to recent or childhood adversity in either the patient or control groups. Overall, our results suggest that telomerase activity is not associated with depression, the therapeutic response to ECT, or exposure to adversity. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: PBMC telomerase activity in depression and the response to electroconvulsive therapy.
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  Data: <searchLink fieldCode="AR" term="%22Ryan%2C+Karen+M%2E%22">Ryan, Karen M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Finnegan%2C+Martha%22">Finnegan, Martha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harkin%2C+Andrew%22">Harkin, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McLoughlin%2C+Declan+M%2E%22">McLoughlin, Declan M.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2021, Vol. 271 Issue 7, p1297-1307. 11p. 1 Chart, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Electroconvulsive+therapy%22">Electroconvulsive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Mononuclear+leukocytes%22">Mononuclear leukocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Telomerase%22">Telomerase</searchLink><br /><searchLink fieldCode="DE" term="%22Hamilton+Depression+Inventory%22">Hamilton Depression Inventory</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+polymerases%22">DNA polymerases</searchLink><br /><searchLink fieldCode="DE" term="%22Ketamine+abuse%22">Ketamine abuse</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Telomerase, the DNA polymerase responsible for maintaining telomere length, has previously been implicated in depression and the response to antidepressant drugs. In this study, we aimed to compare telomerase activity in peripheral blood mononuclear cells between patients with severe depression recruited as part of the KEEP-WELL Trial (Ketamine for Depression Relapse Prevention Following ECT; NCT02414932) and age- and sex-matched healthy volunteers both at baseline/pre-ECT and at follow-up 1 month later for controls or in patients after a course of ECT. We found no differences in telomerase activity between patients with depression (n = 20) compared to healthy controls (n = 33) at baseline/pre-ECT, or between patients treated with ECT compared to controls at follow-up. In patients, telomerase activity was not associated with mood, as assessed by the 24-item Hamilton Rating Scale for Depression, or the duration of the current depressive episode. Additionally, we found no significant relationship between telomerase activity and exposure to recent or childhood adversity in either the patient or control groups. Overall, our results suggest that telomerase activity is not associated with depression, the therapeutic response to ECT, or exposure to adversity. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00406-021-01294-4
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        Text: English
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      – SubjectFull: Telomerase
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      – SubjectFull: Hamilton Depression Inventory
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              Text: Oct2021
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