View in EDS PDF Full Text

Cholinergic transmission from the basal forebrain modulates social memory in male mice.

Saved in:
Bibliographic Details
Title: Cholinergic transmission from the basal forebrain modulates social memory in male mice.
Authors: Kljakic, Ornela (AUTHOR), Al‐Onaizi, Mohammed (AUTHOR), Janíčková, Helena (AUTHOR), Chen, Kevin S. (AUTHOR), Guzman, Monica S. (AUTHOR), Prado, Marco A. M. (AUTHOR), Prado, Vania F. (AUTHOR)
Source: European Journal of Neuroscience. Sep2021, Vol. 54 Issue 6, p6075-6092. 18p. 1 Color Photograph, 1 Diagram, 3 Charts, 3 Graphs.
Subjects: Collective memory, Autism spectrum disorders, Cholinergic mechanisms, Prosencephalon, Social influence
Abstract: Disruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood. The central cholinergic system has been proposed to contribute to the regulation of social behaviour. For instance, decreased global levels of acetylcholine release in the brain leads to decreased social interaction and an impairment of social memory in mice. Nonetheless, it has been difficult to ascertain the specific brain areas where cholinergic signalling influences social preference and social memory. In this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter—the protein that regulates acetylcholine secretion. We found that when cholinergic signalling is highly disrupted in the striatum, hippocampus, cortex and amygdala mice have intact social preference but are impaired in social memory, as they cannot remember a familiar conspecific nor recognize a novel one. A similar pattern emerges when acetylcholine release is disrupted mainly in the striatum, cortex, and amygdala; however, the ability to recognize novel conspecifics is retained. In contrast, cholinergic signalling of the striatum and amygdala does not appear to significantly contribute to the modulation of social memory and social preference. Furthermore, we demonstrated that increasing global cholinergic tone does not increase social behaviours. Together, these data suggest that cholinergic transmission from the hippocampus and cortex are important for regulating social memory. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 152558428
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cholinergic transmission from the basal forebrain modulates social memory in male mice.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kljakic%2C+Ornela%22">Kljakic, Ornela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Al‐Onaizi%2C+Mohammed%22">Al‐Onaizi, Mohammed</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Janíčková%2C+Helena%22">Janíčková, Helena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Kevin+S%2E%22">Chen, Kevin S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guzman%2C+Monica+S%2E%22">Guzman, Monica S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prado%2C+Marco+A%2E+M%2E%22">Prado, Marco A. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prado%2C+Vania+F%2E%22">Prado, Vania F.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2021, Vol. 54 Issue 6, p6075-6092. 18p. 1 Color Photograph, 1 Diagram, 3 Charts, 3 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Collective+memory%22">Collective memory</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Cholinergic+mechanisms%22">Cholinergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Prosencephalon%22">Prosencephalon</searchLink><br /><searchLink fieldCode="DE" term="%22Social+influence%22">Social influence</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Disruptions in social behaviour are prevalent in many neuropsychiatric disorders such as schizophrenia, bipolar disorder and autism spectrum disorders. However, the underlying neurochemical regulation of social behaviour is still not well understood. The central cholinergic system has been proposed to contribute to the regulation of social behaviour. For instance, decreased global levels of acetylcholine release in the brain leads to decreased social interaction and an impairment of social memory in mice. Nonetheless, it has been difficult to ascertain the specific brain areas where cholinergic signalling influences social preference and social memory. In this study, we investigated the impact of different forebrain cholinergic regions on social behaviour by examining mouse lines that differ in their regional expression level of the vesicular acetylcholine transporter—the protein that regulates acetylcholine secretion. We found that when cholinergic signalling is highly disrupted in the striatum, hippocampus, cortex and amygdala mice have intact social preference but are impaired in social memory, as they cannot remember a familiar conspecific nor recognize a novel one. A similar pattern emerges when acetylcholine release is disrupted mainly in the striatum, cortex, and amygdala; however, the ability to recognize novel conspecifics is retained. In contrast, cholinergic signalling of the striatum and amygdala does not appear to significantly contribute to the modulation of social memory and social preference. Furthermore, we demonstrated that increasing global cholinergic tone does not increase social behaviours. Together, these data suggest that cholinergic transmission from the hippocampus and cortex are important for regulating social memory. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=152558428
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ejn.15400
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 6075
    Subjects:
      – SubjectFull: Collective memory
        Type: general
      – SubjectFull: Autism spectrum disorders
        Type: general
      – SubjectFull: Cholinergic mechanisms
        Type: general
      – SubjectFull: Prosencephalon
        Type: general
      – SubjectFull: Social influence
        Type: general
    Titles:
      – TitleFull: Cholinergic transmission from the basal forebrain modulates social memory in male mice.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kljakic, Ornela
      – PersonEntity:
          Name:
            NameFull: Al‐Onaizi, Mohammed
      – PersonEntity:
          Name:
            NameFull: Janíčková, Helena
      – PersonEntity:
          Name:
            NameFull: Chen, Kevin S.
      – PersonEntity:
          Name:
            NameFull: Guzman, Monica S.
      – PersonEntity:
          Name:
            NameFull: Prado, Marco A. M.
      – PersonEntity:
          Name:
            NameFull: Prado, Vania F.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 09
              Text: Sep2021
              Type: published
              Y: 2021
          Identifiers:
            – Type: issn-print
              Value: 0953816X
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: European Journal of Neuroscience
              Type: main
ResultId 1