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Validation of Spanish version of 15‐item myasthenia gravis quality‐of‐life questionnaire.

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Title: Validation of Spanish version of 15‐item myasthenia gravis quality‐of‐life questionnaire.
Authors: Contreras, Juan Pablo (AUTHOR), Salinas, Rodrigo (AUTHOR), Vidal, Carolina (AUTHOR), Hoffmeister, Lorena (AUTHOR), Wolfe, Gil I. (AUTHOR), Cea, Gabriel (AUTHOR)
Source: Acta Neurologica Scandinavica. Nov2021, Vol. 144 Issue 5, p546-552. 7p.
Subjects: Myasthenia gravis, Intraclass correlation, Mann Whitney U Test, Questionnaires, Rank correlation (Statistics)
Geographic Terms: Americas
Abstract: Objectives: The aim of this study was to achieve the translation and cross‐cultural adaptation of the MG‐QOL15R questionnaire into Spanish and the analysis of its psychometric properties. Materials and Methods: We recruited patients with MG, ≥18 years old, whose mother tongue was Spanish. After the translation and cross‐cultural adaptation of the MG‐QOL15‐R, the following tests were performed: internal consistency using the Cronbach‐α coefficient and corrected item‐total correlations; reproducibility with a test‐retest analysis using intraclass correlation coefficients; and concurrent validity using Spearman's correlation coefficient of the Spanish language MG‐QOL15R‐S, Myasthenia Gravis Activity of Daily Living (MG‐ADL) and Quantitative Myasthenia Gravis (QMG) scores. As an approximation to construct validity, the nonparametric Mann‐Whitney U test was performed between MG‐QOL15R‐S scores according to the Myasthenia Gravis Foundation of America classification. Results: A total of 83 MG patients were enrolled, mean age 48.19 ± 17.25 years; 58 (69.9%) were women. The mean MG‐QOL15R‐S score was 11.3 ± 7.1. Cronbach‐α coefficient was 0.92. Item‐total correlation ranged between 0.43 and 0.75. Intraclass correlation coefficient was 0.80. The Spearman correlation coefficient was 0.637 (p‐value <.001) for MG‐ADL and 0.487 (p‐value <.001) for QMG. Mann‐Whitney U tests of the mean MG‐QOL15R‐S scores were significantly different according to the clinical severity (p‐value <.001). Conclusions: The Spanish version of the MG‐QOL15R is a valid and reliable instrument and potentially useful for measuring health‐related quality of life in Spanish‐speaking MG patients. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Validation of Spanish version of 15‐item myasthenia gravis quality‐of‐life questionnaire.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Contreras%2C+Juan+Pablo%22&quot;&gt;Contreras, Juan Pablo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Salinas%2C+Rodrigo%22&quot;&gt;Salinas, Rodrigo&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vidal%2C+Carolina%22&quot;&gt;Vidal, Carolina&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hoffmeister%2C+Lorena%22&quot;&gt;Hoffmeister, Lorena&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wolfe%2C+Gil+I%2E%22&quot;&gt;Wolfe, Gil I.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cea%2C+Gabriel%22&quot;&gt;Cea, Gabriel&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Acta+Neurologica+Scandinavica%22&quot;&gt;Acta Neurologica Scandinavica&lt;/searchLink&gt;. Nov2021, Vol. 144 Issue 5, p546-552. 7p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myasthenia+gravis%22&quot;&gt;Myasthenia gravis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intraclass+correlation%22&quot;&gt;Intraclass correlation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mann+Whitney+U+Test%22&quot;&gt;Mann Whitney U Test&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Questionnaires%22&quot;&gt;Questionnaires&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Rank+correlation+%28Statistics%29%22&quot;&gt;Rank correlation (Statistics)&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Americas%22&quot;&gt;Americas&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Objectives: The aim of this study was to achieve the translation and cross‐cultural adaptation of the MG‐QOL15R questionnaire into Spanish and the analysis of its psychometric properties. Materials and Methods: We recruited patients with MG, ≥18 years old, whose mother tongue was Spanish. After the translation and cross‐cultural adaptation of the MG‐QOL15‐R, the following tests were performed: internal consistency using the Cronbach‐α coefficient and corrected item‐total correlations; reproducibility with a test‐retest analysis using intraclass correlation coefficients; and concurrent validity using Spearman&#39;s correlation coefficient of the Spanish language MG‐QOL15R‐S, Myasthenia Gravis Activity of Daily Living (MG‐ADL) and Quantitative Myasthenia Gravis (QMG) scores. As an approximation to construct validity, the nonparametric Mann‐Whitney U test was performed between MG‐QOL15R‐S scores according to the Myasthenia Gravis Foundation of America classification. Results: A total of 83 MG patients were enrolled, mean age 48.19 &#177; 17.25 years; 58 (69.9%) were women. The mean MG‐QOL15R‐S score was 11.3 &#177; 7.1. Cronbach‐α coefficient was 0.92. Item‐total correlation ranged between 0.43 and 0.75. Intraclass correlation coefficient was 0.80. The Spearman correlation coefficient was 0.637 (p‐value &lt;.001) for MG‐ADL and 0.487 (p‐value &lt;.001) for QMG. Mann‐Whitney U tests of the mean MG‐QOL15R‐S scores were significantly different according to the clinical severity (p‐value &lt;.001). Conclusions: The Spanish version of the MG‐QOL15R is a valid and reliable instrument and potentially useful for measuring health‐related quality of life in Spanish‐speaking MG patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1111/ane.13486
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 546
    Subjects:
      – SubjectFull: Myasthenia gravis
        Type: general
      – SubjectFull: Intraclass correlation
        Type: general
      – SubjectFull: Mann Whitney U Test
        Type: general
      – SubjectFull: Questionnaires
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      – SubjectFull: Rank correlation (Statistics)
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      – SubjectFull: Americas
        Type: general
    Titles:
      – TitleFull: Validation of Spanish version of 15‐item myasthenia gravis quality‐of‐life questionnaire.
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            NameFull: Contreras, Juan Pablo
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            – D: 01
              M: 11
              Text: Nov2021
              Type: published
              Y: 2021
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