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Change in cognition before and after non-central nervous system cancer diagnosis: A population-based cohort study.

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Title: Change in cognition before and after non-central nervous system cancer diagnosis: A population-based cohort study.
Authors: van der Willik, Kimberly D. (AUTHOR), Jóźwiak, Katarzyna (AUTHOR), Hauptmann, Michael (AUTHOR), van de Velde, Edolie E.D. (AUTHOR), Compter, Annette (AUTHOR), Ruiter, Rikje (AUTHOR), Stricker, Bruno H. (AUTHOR), Ikram, M. Arfan (AUTHOR), Schagen, Sanne B. (AUTHOR)
Source: Psycho-Oncology. Oct2021, Vol. 30 Issue 10, p1699-1710. 12p. 4 Charts, 3 Graphs.
Subjects: Cancer diagnosis, Nervous system, Cognition, Cognitive ability, Cognition disorders, Central nervous system tumors
Abstract: Objective: Clinical studies showing that non-central nervous system cancer patients can develop cognitive impairment have primarily focused on patients with specific cancer types and intensive treatments. To better understand the course of cognitive function in the general population of cancer patients, we assessed cognitive trajectories of patients before and after cancer diagnosis in a population-based setting.Methods: Between 1989 and 2014, 2211 participants from the population-based Rotterdam study had been diagnosed with cancer of whom 718 (32.5%) had undergone ≥1 cognitive assessment before and after diagnosis. Cognition was measured every 3 to 6 years using a neuropsychological battery. Linear mixed models were used to compare cognitive trajectories of patients before and after diagnosis with those of age-matched cancer-free controls (1:3).Results: Median age at cancer diagnosis was 70.3 years and 47.1% were women. Most patients (68.1%) had received local treatment only. Cognitive trajectories of patients before and after cancer diagnosis were largely similar to those of controls. After diagnosis, the largest difference was found on a memory test (patients declined with 0.14 units per year on the Word Learning Test: delayed recall [95% CI = -0.35; 0.07] and controls with 0.09 units [95% CI = -0.18;-0.00], p for difference = .59).Conclusions: In this longitudinal cohort, cancer did not appear to alter the trajectory of change in cognitive test results over time from that seen in similar individuals without cancer, although most cancer patients did not receive systemic therapies. Future studies should focus on identifying subgroups of patients who are at high risk for developing cognitive impairment. [ABSTRACT FROM AUTHOR]
Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Change in cognition before and after non-central nervous system cancer diagnosis: A population-based cohort study.
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  Data: <searchLink fieldCode="AR" term="%22van+der+Willik%2C+Kimberly+D%2E%22">van der Willik, Kimberly D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jóźwiak%2C+Katarzyna%22">Jóźwiak, Katarzyna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hauptmann%2C+Michael%22">Hauptmann, Michael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22van+de+Velde%2C+Edolie+E%2ED%2E%22">van de Velde, Edolie E.D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Compter%2C+Annette%22">Compter, Annette</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruiter%2C+Rikje%22">Ruiter, Rikje</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stricker%2C+Bruno+H%2E%22">Stricker, Bruno H.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ikram%2C+M%2E+Arfan%22">Ikram, M. Arfan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schagen%2C+Sanne+B%2E%22">Schagen, Sanne B.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psycho-Oncology%22">Psycho-Oncology</searchLink>. Oct2021, Vol. 30 Issue 10, p1699-1710. 12p. 4 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Cancer+diagnosis%22">Cancer diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Nervous+system%22">Nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system+tumors%22">Central nervous system tumors</searchLink>
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  Label: Abstract
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  Data: <bold>Objective: </bold>Clinical studies showing that non-central nervous system cancer patients can develop cognitive impairment have primarily focused on patients with specific cancer types and intensive treatments. To better understand the course of cognitive function in the general population of cancer patients, we assessed cognitive trajectories of patients before and after cancer diagnosis in a population-based setting.<bold>Methods: </bold>Between 1989 and 2014, 2211 participants from the population-based Rotterdam study had been diagnosed with cancer of whom 718 (32.5%) had undergone ≥1 cognitive assessment before and after diagnosis. Cognition was measured every 3 to 6 years using a neuropsychological battery. Linear mixed models were used to compare cognitive trajectories of patients before and after diagnosis with those of age-matched cancer-free controls (1:3).<bold>Results: </bold>Median age at cancer diagnosis was 70.3 years and 47.1% were women. Most patients (68.1%) had received local treatment only. Cognitive trajectories of patients before and after cancer diagnosis were largely similar to those of controls. After diagnosis, the largest difference was found on a memory test (patients declined with 0.14 units per year on the Word Learning Test: delayed recall [95% CI = -0.35; 0.07] and controls with 0.09 units [95% CI = -0.18;-0.00], p for difference = .59).<bold>Conclusions: </bold>In this longitudinal cohort, cancer did not appear to alter the trajectory of change in cognitive test results over time from that seen in similar individuals without cancer, although most cancer patients did not receive systemic therapies. Future studies should focus on identifying subgroups of patients who are at high risk for developing cognitive impairment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psycho-Oncology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Central nervous system tumors
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              Text: Oct2021
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