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Cone photoreceptor density in the Copenhagen Child Cohort at age 16–17 years.

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Title: Cone photoreceptor density in the Copenhagen Child Cohort at age 16–17 years.
Authors: Eckmann‐Hansen, Christina (AUTHOR), Hansen, Mathias Hvidtfelt (AUTHOR), Laigaard, Poul Pedersen (AUTHOR), Sander, Birgit Agnes (AUTHOR), Munch, Inger Christine (AUTHOR), Olsen, Else Marie (AUTHOR), Skovgaard, Anne Mette (AUTHOR), Larsen, Michael (AUTHOR)
Source: Ophthalmic & Physiological Optics. Nov2021, Vol. 41 Issue 6, p1292-1299. 8p. 1 Diagram, 5 Charts, 4 Graphs.
Subjects: Cones, Photoreceptors, Pearson correlation (Statistics), Density, Adaptive optics
Abstract: Purpose: To examine cone density in relation to gestational and morphological parameters in the Copenhagen Child Cohort (CCC2000). Methods: The macula was imaged using adaptive optics in 1,296 adolescents aged 16–17 years. Axial length and distance visual acuity were determined. Absolute and angular cone photoreceptor density were analysed for an 80 × 80‐pixel area, 2 degrees temporal to the fovea. Association with axial length was analysed with linear regression. Correlation with visual acuity was described with a Pearson correlation coefficient. Associations of cone density with gestational parameters, maternal smoking, sex and age were analysed using multiple regression adjusted for axial length. Results: Mean absolute cone density was 30,007 cones/mm2 (SD ± 3,802) and mean angular cone density was 2,383 cones/deg2 (SD ± 231). Peri‐ and postnatal parameters, sex and age had no statistically significant effect on cone density (p > 0.05). Absolute cone density decreased with longer axial length (−2,855 cones/mm2 per mm or −9.7% per mm, p < 0.0001). For angular density, which included a correction for the geometrical enlargement of the eye with axial length, a decrease with axial length was detectable, but it was small (−20 cones/deg2 per mm or −0.84% per mm, p = 0.009). Conclusions: The decrease in cone density per unit solid angle with increasing axial length was small, less than 1 percent per mm, indicating that expansion of the posterior pole during the development of refraction takes place without a clinically significant loss of cones. Perinatal parameters, within the spectrum presented by the study population, had no detectable effect on cone density. [ABSTRACT FROM AUTHOR]
Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cone photoreceptor density in the Copenhagen Child Cohort at age 16–17&#160;years.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Eckmann‐Hansen%2C+Christina%22&quot;&gt;Eckmann‐Hansen, Christina&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hansen%2C+Mathias+Hvidtfelt%22&quot;&gt;Hansen, Mathias Hvidtfelt&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Laigaard%2C+Poul+Pedersen%22&quot;&gt;Laigaard, Poul Pedersen&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sander%2C+Birgit+Agnes%22&quot;&gt;Sander, Birgit Agnes&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Munch%2C+Inger+Christine%22&quot;&gt;Munch, Inger Christine&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Olsen%2C+Else+Marie%22&quot;&gt;Olsen, Else Marie&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Skovgaard%2C+Anne+Mette%22&quot;&gt;Skovgaard, Anne Mette&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Larsen%2C+Michael%22&quot;&gt;Larsen, Michael&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Ophthalmic+%26+Physiological+Optics%22&quot;&gt;Ophthalmic &amp; Physiological Optics&lt;/searchLink&gt;. Nov2021, Vol. 41 Issue 6, p1292-1299. 8p. 1 Diagram, 5 Charts, 4 Graphs.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cones%22&quot;&gt;Cones&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Photoreceptors%22&quot;&gt;Photoreceptors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pearson+correlation+%28Statistics%29%22&quot;&gt;Pearson correlation (Statistics)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Density%22&quot;&gt;Density&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Adaptive+optics%22&quot;&gt;Adaptive optics&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Purpose: To examine cone density in relation to gestational and morphological parameters in the Copenhagen Child Cohort (CCC2000). Methods: The macula was imaged using adaptive optics in 1,296 adolescents aged 16–17 years. Axial length and distance visual acuity were determined. Absolute and angular cone photoreceptor density were analysed for an 80 &#215; 80‐pixel area, 2 degrees temporal to the fovea. Association with axial length was analysed with linear regression. Correlation with visual acuity was described with a Pearson correlation coefficient. Associations of cone density with gestational parameters, maternal smoking, sex and age were analysed using multiple regression adjusted for axial length. Results: Mean absolute cone density was 30,007 cones/mm2 (SD &#177; 3,802) and mean angular cone density was 2,383 cones/deg2 (SD &#177; 231). Peri‐ and postnatal parameters, sex and age had no statistically significant effect on cone density (p &gt; 0.05). Absolute cone density decreased with longer axial length (−2,855 cones/mm2 per mm or −9.7% per mm, p &lt; 0.0001). For angular density, which included a correction for the geometrical enlargement of the eye with axial length, a decrease with axial length was detectable, but it was small (−20 cones/deg2 per mm or −0.84% per mm, p = 0.009). Conclusions: The decrease in cone density per unit solid angle with increasing axial length was small, less than 1 percent per mm, indicating that expansion of the posterior pole during the development of refraction takes place without a clinically significant loss of cones. Perinatal parameters, within the spectrum presented by the study population, had no detectable effect on cone density. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Ophthalmic &amp; Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/opo.12889
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1292
    Subjects:
      – SubjectFull: Cones
        Type: general
      – SubjectFull: Photoreceptors
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Density
        Type: general
      – SubjectFull: Adaptive optics
        Type: general
    Titles:
      – TitleFull: Cone photoreceptor density in the Copenhagen Child Cohort at age 16–17 years.
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            NameFull: Eckmann‐Hansen, Christina
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            NameFull: Hansen, Mathias Hvidtfelt
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            NameFull: Laigaard, Poul Pedersen
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            NameFull: Sander, Birgit Agnes
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            NameFull: Munch, Inger Christine
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            NameFull: Olsen, Else Marie
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            NameFull: Skovgaard, Anne Mette
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            – D: 01
              M: 11
              Text: Nov2021
              Type: published
              Y: 2021
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            – TitleFull: Ophthalmic & Physiological Optics
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