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Use of register‐ and survey‐based measures of anxiety in a population‐based Danish cohort.

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Title: Use of register‐ and survey‐based measures of anxiety in a population‐based Danish cohort.
Authors: Osler, Merete (AUTHOR), Rozing, Maarten Pieter (AUTHOR), Wium‐Andersen, Ida Kim (AUTHOR), Wium‐Andersen, Marie Kim (AUTHOR), Dantoft, Thomas Meinertz (AUTHOR), Fink, Per (AUTHOR), Jørgensen, Martin Balslev (AUTHOR), Jørgensen, Terese Sara Høj (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Nov2021, Vol. 144 Issue 5, p501-509. 9p. 2 Diagrams, 2 Charts.
Subjects: Tranquilizing drugs, Anxiety, Drug prescribing, Measurement errors, Mental illness, Self-poisoning
Abstract: Objective: We explored the comparability of anxiety measures from register‐ and survey‐based data including analyses of prevalence and associations with selected psychiatric and somatic diseases. Methods: We measured anxiety using Danish registers (hospital diagnosis and anxiolytic drug prescriptions), self‐reports, symptom checklist (SCL) scores, and a clinical interview in 7493 adults with mean age 52 (SD 13.3) years who participated in a health survey between 2012 and 2015. We estimated the prevalence of anxiety, agreement between different measures and performed quantitative bias analysis. Results: The lifetime prevalence of hospital diagnosed anxiety, anxiolytic drug prescriptions, and self‐reported anxiety were 4.4%, 6.2%, and 5.1%, respectively, after adjusting for selective participation. The agreement between the different anxiety measures was low. Thus, 25% with an anxiety diagnosis and 20% with anxiolytic drug prescriptions also had a high SCL score. Anxiolytic drugs were the only measure significantly associated with higher odds of heart disease. Hospital diagnosis and self‐reported anxiety were associated with depression with odds ratio (OR) above 15, whereas anxiolytic drug prescriptions were less strongly associated (OR = 2.2(95% confidence interval: 1.26–3.91)). The risk estimates attenuated considerably when correcting for measurement error, whereas the ORs became slightly higher when the selective participation in the survey was accounted for. Conclusion: Anxiety diagnosed in hospitals and self‐reported anxiety showed low level of agreement but provide comparable results regarding frequency measures and associations with disease outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Use of register‐ and survey‐based measures of anxiety in a population‐based Danish cohort.
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  Data: <searchLink fieldCode="AR" term="%22Osler%2C+Merete%22">Osler, Merete</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rozing%2C+Maarten+Pieter%22">Rozing, Maarten Pieter</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wium‐Andersen%2C+Ida+Kim%22">Wium‐Andersen, Ida Kim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wium‐Andersen%2C+Marie+Kim%22">Wium‐Andersen, Marie Kim</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dantoft%2C+Thomas+Meinertz%22">Dantoft, Thomas Meinertz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fink%2C+Per%22">Fink, Per</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jørgensen%2C+Martin+Balslev%22">Jørgensen, Martin Balslev</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jørgensen%2C+Terese+Sara+Høj%22">Jørgensen, Terese Sara Høj</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Nov2021, Vol. 144 Issue 5, p501-509. 9p. 2 Diagrams, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Tranquilizing+drugs%22">Tranquilizing drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+prescribing%22">Drug prescribing</searchLink><br /><searchLink fieldCode="DE" term="%22Measurement+errors%22">Measurement errors</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Self-poisoning%22">Self-poisoning</searchLink>
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  Data: Objective: We explored the comparability of anxiety measures from register‐ and survey‐based data including analyses of prevalence and associations with selected psychiatric and somatic diseases. Methods: We measured anxiety using Danish registers (hospital diagnosis and anxiolytic drug prescriptions), self‐reports, symptom checklist (SCL) scores, and a clinical interview in 7493 adults with mean age 52 (SD 13.3) years who participated in a health survey between 2012 and 2015. We estimated the prevalence of anxiety, agreement between different measures and performed quantitative bias analysis. Results: The lifetime prevalence of hospital diagnosed anxiety, anxiolytic drug prescriptions, and self‐reported anxiety were 4.4%, 6.2%, and 5.1%, respectively, after adjusting for selective participation. The agreement between the different anxiety measures was low. Thus, 25% with an anxiety diagnosis and 20% with anxiolytic drug prescriptions also had a high SCL score. Anxiolytic drugs were the only measure significantly associated with higher odds of heart disease. Hospital diagnosis and self‐reported anxiety were associated with depression with odds ratio (OR) above 15, whereas anxiolytic drug prescriptions were less strongly associated (OR = 2.2(95% confidence interval: 1.26–3.91)). The risk estimates attenuated considerably when correcting for measurement error, whereas the ORs became slightly higher when the selective participation in the survey was accounted for. Conclusion: Anxiety diagnosed in hospitals and self‐reported anxiety showed low level of agreement but provide comparable results regarding frequency measures and associations with disease outcomes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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      – SubjectFull: Drug prescribing
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              M: 11
              Text: Nov2021
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